Prognostic impact of local treatment against postoperative oligometastases in non-small cell lung cancer

Tokujiro Yano, Akira Haro, Tsukihisa Yoshida, Yosuke Morodomi, Kensaku Ito, Yasunori Shikada, Fumihiro Shoji, Riichiroh Maruyama, Yoshihiko Maehara

Research output: Contribution to journalArticle

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Abstract

Objective: s In this study, we investigated prognostic factors associated with survival after distantly metastatic recurrence in surgically resected non-small cell lung cancer (NSCLC), and clarified the influence of local treatment on the prognosis for oligometastatic recurrence. Methods From 1994 through 2004, 418 consecutive patients with NSCLC underwent complete resection; 138 experienced a postoperative recurrence by December 2005. Of those, we reviewed 93 patients with only distant metastases for clinicopathological information, treatment modality, and survival. Results For the 93 patients with distant metastasis alone, the 2- and 5-year survival rates after recurrence were 43.9% and 38.7%, respectively. Of those patients, 44 first received local treatment, including radiotherapy in 31 and a surgical resection in 13. Their recurrent disease (oligometastases) was limited with the potential to be controlled with local treatment. The targeted metastatic organs were brain in 14 patients, bone in 14, lungs in 12, and other organs in 4. Significant prognostic factors for postrecurrence survival included adenocarcinoma histology, long disease-free interval (DFI) (1 year or longer), and the performance of local treatment for oligometastases. Conclusion Local therapy such as radiotherapy and surgery, might be considered first-line treatment in patients with postoperative oligometastatic recurrence, especially those with a DFI ≥ 1 year.

Original languageEnglish
Pages (from-to)852-855
Number of pages4
JournalJournal of Surgical Oncology
Volume102
Issue number7
DOIs
Publication statusPublished - Dec 1 2010

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Non-Small Cell Lung Carcinoma
Recurrence
Therapeutics
Survival
Radiotherapy
Neoplasm Metastasis
Histology
Adenocarcinoma
Survival Rate
Bone and Bones
Lung
Brain

All Science Journal Classification (ASJC) codes

  • Surgery
  • Oncology

Cite this

Yano, T., Haro, A., Yoshida, T., Morodomi, Y., Ito, K., Shikada, Y., ... Maehara, Y. (2010). Prognostic impact of local treatment against postoperative oligometastases in non-small cell lung cancer. Journal of Surgical Oncology, 102(7), 852-855. https://doi.org/10.1002/jso.21750

Prognostic impact of local treatment against postoperative oligometastases in non-small cell lung cancer. / Yano, Tokujiro; Haro, Akira; Yoshida, Tsukihisa; Morodomi, Yosuke; Ito, Kensaku; Shikada, Yasunori; Shoji, Fumihiro; Maruyama, Riichiroh; Maehara, Yoshihiko.

In: Journal of Surgical Oncology, Vol. 102, No. 7, 01.12.2010, p. 852-855.

Research output: Contribution to journalArticle

Yano, T, Haro, A, Yoshida, T, Morodomi, Y, Ito, K, Shikada, Y, Shoji, F, Maruyama, R & Maehara, Y 2010, 'Prognostic impact of local treatment against postoperative oligometastases in non-small cell lung cancer', Journal of Surgical Oncology, vol. 102, no. 7, pp. 852-855. https://doi.org/10.1002/jso.21750
Yano, Tokujiro ; Haro, Akira ; Yoshida, Tsukihisa ; Morodomi, Yosuke ; Ito, Kensaku ; Shikada, Yasunori ; Shoji, Fumihiro ; Maruyama, Riichiroh ; Maehara, Yoshihiko. / Prognostic impact of local treatment against postoperative oligometastases in non-small cell lung cancer. In: Journal of Surgical Oncology. 2010 ; Vol. 102, No. 7. pp. 852-855.
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AB - Objective: s In this study, we investigated prognostic factors associated with survival after distantly metastatic recurrence in surgically resected non-small cell lung cancer (NSCLC), and clarified the influence of local treatment on the prognosis for oligometastatic recurrence. Methods From 1994 through 2004, 418 consecutive patients with NSCLC underwent complete resection; 138 experienced a postoperative recurrence by December 2005. Of those, we reviewed 93 patients with only distant metastases for clinicopathological information, treatment modality, and survival. Results For the 93 patients with distant metastasis alone, the 2- and 5-year survival rates after recurrence were 43.9% and 38.7%, respectively. Of those patients, 44 first received local treatment, including radiotherapy in 31 and a surgical resection in 13. Their recurrent disease (oligometastases) was limited with the potential to be controlled with local treatment. The targeted metastatic organs were brain in 14 patients, bone in 14, lungs in 12, and other organs in 4. Significant prognostic factors for postrecurrence survival included adenocarcinoma histology, long disease-free interval (DFI) (1 year or longer), and the performance of local treatment for oligometastases. Conclusion Local therapy such as radiotherapy and surgery, might be considered first-line treatment in patients with postoperative oligometastatic recurrence, especially those with a DFI ≥ 1 year.

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