Prognostic Impact of the Neutrophil-to-Lymphocyte Ratio in Stage I-II Rectal Cancer Patients

Daisuke Yoshida, Kazuhito Minami, Masahiko Sugiyama, Mitsuhiko Ota, Masahiko Ikebe, Masaru Morita, A. Matsukuma, Yasushi Toh

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

Background: Systemic inflammation and immune response play crucial roles in tumor growth; neutrophil-to-lymphocyte ratio (NLR) is a known systemic inflammatory scoring system. Previous studies have reported that NLR is a prognostic biomarker in various human cancers. The aim of this study was to determine whether the NLR predicts tumor recurrence in patients with stage I-II rectal cancer after curative resection. Methods: We retrospectively analyzed 130 consecutive patients with stage I-II rectal cancer who underwent curative resection between January 2006 and March 2015 at our institution without any preoperative treatment. We investigated whether clinicopathologic factors including NLR were associated with cancer recurrence after curative surgery. Results: There were four cases (3.1%) of cancer-specific deaths and 16 cases (12.3%) of recurrence; the 5-year disease-free survival rate was 85.6%. NLR, pathologic T-category, and lymphatic invasion were significantly associated with disease-free survival. Multivariate analysis further showed that these three factors were independently associated with disease-free survival. Conclusions: Preoperative NLR could predict tumor relapse in stage I-II rectal cancer and might be a useful biomarker for predicting recurrence in patients undergoing curative resection.

Original languageEnglish
Pages (from-to)281-287
Number of pages7
JournalJournal of Surgical Research
Volume245
DOIs
Publication statusPublished - Jan 2020
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Surgery

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