Prognostic impact of tumoral and/or peri-tumoral stromal SPARC expressions after surgery in patients with biliary tract cancer

Shinsuke Nakashima, Shogo Kobayashi, Daisuke Sakai, Akira Tomokuni, Yoshito Tomimaru, Naoki Hama, Hiroshi Wada, Koichi Kawamoto, Shigeru Marubashi, Hidetoshi Eguchi, Nariaki Matsuura, Yuichiro Doki, Masaki Mori, Hiroaki Nagano

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Background and Objective: SPARC (secreted protein acidic and rich in cysteine) is a matricellular glycoprotein that modulates interactions between tumoral cells and the peri-tumoralstroma. SPARC induces proliferation and invasion in vitro, and is a poor prognostic factor in several gastrointestinal cancers. Herein, we evaluated the prognostic value of tumoral and stromal SPARC expression in patients with biliary tract cancer (BTC) after surgery.

Methods: We examined immunohistochemical patterns of SPARC expression in 110 resected BTC specimens and evaluated the prognostic value using prospectively collected data.

Results: SPARC was expressed in tumoral cells in 46 samples (42%) and inperi-tumoralstromain 65 samples (59%). Tumoral SPARC expression was not related to major patient characteristics. Stromal SPARC expression was related to lymph node metastasis, stage, margin status, and tumor location. Overall survival at 5 years after surgery was 34.2%. Stromal SPARC (P 0.001) and tumoral SPARC (P=0.048) were associated with poor prognosis. Multivariate analysis revealed invasion into lymphatic system, residual tumor, and stromal SPARC as independent prognostic factors. The hazard ratio for patients with positive stromal SPARC was 3.20 (P 0.001). Conclusion: SPARC expression inperi-tumoralstroma predicts a poor prognosis for patients with BTC after surgery.

Original languageEnglish
Pages (from-to)1016-1022
Number of pages7
JournalJournal of Surgical Oncology
Volume110
Issue number8
DOIs
Publication statusPublished - Dec 1 2014
Externally publishedYes

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Biliary Tract Neoplasms
Cysteine
Proteins
Lymphatic System
Gastrointestinal Neoplasms
Residual Neoplasm

All Science Journal Classification (ASJC) codes

  • Surgery
  • Oncology

Cite this

Nakashima, S., Kobayashi, S., Sakai, D., Tomokuni, A., Tomimaru, Y., Hama, N., ... Nagano, H. (2014). Prognostic impact of tumoral and/or peri-tumoral stromal SPARC expressions after surgery in patients with biliary tract cancer. Journal of Surgical Oncology, 110(8), 1016-1022. https://doi.org/10.1002/jso.23767

Prognostic impact of tumoral and/or peri-tumoral stromal SPARC expressions after surgery in patients with biliary tract cancer. / Nakashima, Shinsuke; Kobayashi, Shogo; Sakai, Daisuke; Tomokuni, Akira; Tomimaru, Yoshito; Hama, Naoki; Wada, Hiroshi; Kawamoto, Koichi; Marubashi, Shigeru; Eguchi, Hidetoshi; Matsuura, Nariaki; Doki, Yuichiro; Mori, Masaki; Nagano, Hiroaki.

In: Journal of Surgical Oncology, Vol. 110, No. 8, 01.12.2014, p. 1016-1022.

Research output: Contribution to journalArticle

Nakashima, S, Kobayashi, S, Sakai, D, Tomokuni, A, Tomimaru, Y, Hama, N, Wada, H, Kawamoto, K, Marubashi, S, Eguchi, H, Matsuura, N, Doki, Y, Mori, M & Nagano, H 2014, 'Prognostic impact of tumoral and/or peri-tumoral stromal SPARC expressions after surgery in patients with biliary tract cancer', Journal of Surgical Oncology, vol. 110, no. 8, pp. 1016-1022. https://doi.org/10.1002/jso.23767
Nakashima, Shinsuke ; Kobayashi, Shogo ; Sakai, Daisuke ; Tomokuni, Akira ; Tomimaru, Yoshito ; Hama, Naoki ; Wada, Hiroshi ; Kawamoto, Koichi ; Marubashi, Shigeru ; Eguchi, Hidetoshi ; Matsuura, Nariaki ; Doki, Yuichiro ; Mori, Masaki ; Nagano, Hiroaki. / Prognostic impact of tumoral and/or peri-tumoral stromal SPARC expressions after surgery in patients with biliary tract cancer. In: Journal of Surgical Oncology. 2014 ; Vol. 110, No. 8. pp. 1016-1022.
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abstract = "Background and Objective: SPARC (secreted protein acidic and rich in cysteine) is a matricellular glycoprotein that modulates interactions between tumoral cells and the peri-tumoralstroma. SPARC induces proliferation and invasion in vitro, and is a poor prognostic factor in several gastrointestinal cancers. Herein, we evaluated the prognostic value of tumoral and stromal SPARC expression in patients with biliary tract cancer (BTC) after surgery.Methods: We examined immunohistochemical patterns of SPARC expression in 110 resected BTC specimens and evaluated the prognostic value using prospectively collected data.Results: SPARC was expressed in tumoral cells in 46 samples (42{\%}) and inperi-tumoralstromain 65 samples (59{\%}). Tumoral SPARC expression was not related to major patient characteristics. Stromal SPARC expression was related to lymph node metastasis, stage, margin status, and tumor location. Overall survival at 5 years after surgery was 34.2{\%}. Stromal SPARC (P 0.001) and tumoral SPARC (P=0.048) were associated with poor prognosis. Multivariate analysis revealed invasion into lymphatic system, residual tumor, and stromal SPARC as independent prognostic factors. The hazard ratio for patients with positive stromal SPARC was 3.20 (P 0.001). Conclusion: SPARC expression inperi-tumoralstroma predicts a poor prognosis for patients with BTC after surgery.",
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T1 - Prognostic impact of tumoral and/or peri-tumoral stromal SPARC expressions after surgery in patients with biliary tract cancer

AU - Nakashima, Shinsuke

AU - Kobayashi, Shogo

AU - Sakai, Daisuke

AU - Tomokuni, Akira

AU - Tomimaru, Yoshito

AU - Hama, Naoki

AU - Wada, Hiroshi

AU - Kawamoto, Koichi

AU - Marubashi, Shigeru

AU - Eguchi, Hidetoshi

AU - Matsuura, Nariaki

AU - Doki, Yuichiro

AU - Mori, Masaki

AU - Nagano, Hiroaki

PY - 2014/12/1

Y1 - 2014/12/1

N2 - Background and Objective: SPARC (secreted protein acidic and rich in cysteine) is a matricellular glycoprotein that modulates interactions between tumoral cells and the peri-tumoralstroma. SPARC induces proliferation and invasion in vitro, and is a poor prognostic factor in several gastrointestinal cancers. Herein, we evaluated the prognostic value of tumoral and stromal SPARC expression in patients with biliary tract cancer (BTC) after surgery.Methods: We examined immunohistochemical patterns of SPARC expression in 110 resected BTC specimens and evaluated the prognostic value using prospectively collected data.Results: SPARC was expressed in tumoral cells in 46 samples (42%) and inperi-tumoralstromain 65 samples (59%). Tumoral SPARC expression was not related to major patient characteristics. Stromal SPARC expression was related to lymph node metastasis, stage, margin status, and tumor location. Overall survival at 5 years after surgery was 34.2%. Stromal SPARC (P 0.001) and tumoral SPARC (P=0.048) were associated with poor prognosis. Multivariate analysis revealed invasion into lymphatic system, residual tumor, and stromal SPARC as independent prognostic factors. The hazard ratio for patients with positive stromal SPARC was 3.20 (P 0.001). Conclusion: SPARC expression inperi-tumoralstroma predicts a poor prognosis for patients with BTC after surgery.

AB - Background and Objective: SPARC (secreted protein acidic and rich in cysteine) is a matricellular glycoprotein that modulates interactions between tumoral cells and the peri-tumoralstroma. SPARC induces proliferation and invasion in vitro, and is a poor prognostic factor in several gastrointestinal cancers. Herein, we evaluated the prognostic value of tumoral and stromal SPARC expression in patients with biliary tract cancer (BTC) after surgery.Methods: We examined immunohistochemical patterns of SPARC expression in 110 resected BTC specimens and evaluated the prognostic value using prospectively collected data.Results: SPARC was expressed in tumoral cells in 46 samples (42%) and inperi-tumoralstromain 65 samples (59%). Tumoral SPARC expression was not related to major patient characteristics. Stromal SPARC expression was related to lymph node metastasis, stage, margin status, and tumor location. Overall survival at 5 years after surgery was 34.2%. Stromal SPARC (P 0.001) and tumoral SPARC (P=0.048) were associated with poor prognosis. Multivariate analysis revealed invasion into lymphatic system, residual tumor, and stromal SPARC as independent prognostic factors. The hazard ratio for patients with positive stromal SPARC was 3.20 (P 0.001). Conclusion: SPARC expression inperi-tumoralstroma predicts a poor prognosis for patients with BTC after surgery.

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