Prognostic implications of the nuclear localization of Y-box-binding protein-1 and CXCR4 expression in ovarian cancer: Their correlation with activated Akt, LRP/MVP and P-glycoprotein expression

Yoshinao Oda, Yoshihiro Ohishi, Yuji Basaki, Hiroaki Kobayashi, Toshio Hirakawa, Norio Wake, Mayumi Ono, Kazuto Nishio, Michihiko Kuwano, Masazumi Tsuneyoshi

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Abstract

The nuclear localization of Y-box-binding protein-1 (YB-1) is known to be a poor prognostic factor in several human malignancies, including ovarian carcinoma. Following on from our basic study dealing with microarray analyses of YB-1-associated gene expression in ovarian cancer cells, we examined whether nuclear localization of YB-1 is associated with the expression of CXCR4, a vault protein named lung resistance-related vault protein (LRP/MVP), phosphorylated Akt (p-Akt) or P-glycoprotein (P-gp) in human ovarian carcinoma. Fifty-three surgically resected ovarian carcinomas treated with paclitaxel and carboplatin were examined immunohistochemically for nuclear YB-1 expression and intrinsic expression of p-Akt, P-gp, LRP/MVP and CXCR4. Nuclear expression of YB-1 demonstrated significant correlation with p-Akt, P-gp and LRP expression, but no relationship with CXCR4 expression. By multivariate analysis, only YB-1 nuclear expression and CXCR4 expression were independent prognostic factors with regard to overall survival. These results indicate that YB-1 nuclear expression and CXCR4 expression are important prognostic factors in ovarian carcinoma.

Original languageEnglish
Pages (from-to)1020-1026
Number of pages7
JournalCancer Science
Volume98
Issue number7
DOIs
Publication statusPublished - Jul 1 2007

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All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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