Prognostic outcome and complications of sentinel lymph node navigation surgery for early-stage cervical cancer

Hideaki Yahata, Hiroaki Kobayashi, Kenzo Sonoda, Keisuke Kodama, hiroshi yagi, Masafumi Yasunaga, Tatsuhiro Ogami, Ichiro Onoyama, Kaneki Eisuke, Okugawa Kaoru, Shingo Baba, Takuro Isoda, Yoshihiro Ohishi, Yoshinao Oda, Kiyoko Kato

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Abstract

Background: To evaluate the prognostic outcome and surgical complications in patients with early-stage cervical cancer who underwent sentinel node navigation surgery (SNNS) for hysterectomy or trachelectomy. Methods: A total of 139 patients who underwent SNNS using 99mTc phytate between 2009 and 2015 were evaluated. No further lymph node dissection was performed when intraoperative analysis of the sentinel lymph nodes (SLNs) was negative for metastasis. We compared the surgical complications between the SNNS group and 67 matched patients who underwent pelvic lymph node dissection (PLND) after SLN mapping between 2003 and 2008. We also examined the clinical outcomes in the SNNS group. Results: The mean number of detected SLNs was 2.5 per patient. Fourteen of the 139 patients in the SNNS group underwent PLND based on the intraoperative SLN results. The amount of blood loss, the operative time, and the number of perioperative complications were significantly less in the SNNS group than in the matched PLND group. There was no recurrence during a follow-up period ranging from 2 to 88 months (median 40 months) in the SNNS group. Conclusions: Using SNNS for early-stage cervical cancer is safe and effective and does not increase the recurrence rate. A future multicenter trial is warranted.

Original languageEnglish
Pages (from-to)1167-1172
Number of pages6
JournalInternational Journal of Clinical Oncology
Volume23
Issue number6
DOIs
Publication statusPublished - Dec 1 2018

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Uterine Cervical Neoplasms
Lymph Node Excision
Research Design
Recurrence
Phytic Acid
cyhalothrin
Sentinel Lymph Node
Operative Time
Hysterectomy
Multicenter Studies
Neoplasm Metastasis

All Science Journal Classification (ASJC) codes

  • Surgery
  • Hematology
  • Oncology

Cite this

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title = "Prognostic outcome and complications of sentinel lymph node navigation surgery for early-stage cervical cancer",
abstract = "Background: To evaluate the prognostic outcome and surgical complications in patients with early-stage cervical cancer who underwent sentinel node navigation surgery (SNNS) for hysterectomy or trachelectomy. Methods: A total of 139 patients who underwent SNNS using 99mTc phytate between 2009 and 2015 were evaluated. No further lymph node dissection was performed when intraoperative analysis of the sentinel lymph nodes (SLNs) was negative for metastasis. We compared the surgical complications between the SNNS group and 67 matched patients who underwent pelvic lymph node dissection (PLND) after SLN mapping between 2003 and 2008. We also examined the clinical outcomes in the SNNS group. Results: The mean number of detected SLNs was 2.5 per patient. Fourteen of the 139 patients in the SNNS group underwent PLND based on the intraoperative SLN results. The amount of blood loss, the operative time, and the number of perioperative complications were significantly less in the SNNS group than in the matched PLND group. There was no recurrence during a follow-up period ranging from 2 to 88 months (median 40 months) in the SNNS group. Conclusions: Using SNNS for early-stage cervical cancer is safe and effective and does not increase the recurrence rate. A future multicenter trial is warranted.",
author = "Hideaki Yahata and Hiroaki Kobayashi and Kenzo Sonoda and Keisuke Kodama and hiroshi yagi and Masafumi Yasunaga and Tatsuhiro Ogami and Ichiro Onoyama and Kaneki Eisuke and Okugawa Kaoru and Shingo Baba and Takuro Isoda and Yoshihiro Ohishi and Yoshinao Oda and Kiyoko Kato",
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T1 - Prognostic outcome and complications of sentinel lymph node navigation surgery for early-stage cervical cancer

AU - Yahata, Hideaki

AU - Kobayashi, Hiroaki

AU - Sonoda, Kenzo

AU - Kodama, Keisuke

AU - yagi, hiroshi

AU - Yasunaga, Masafumi

AU - Ogami, Tatsuhiro

AU - Onoyama, Ichiro

AU - Eisuke, Kaneki

AU - Kaoru, Okugawa

AU - Baba, Shingo

AU - Isoda, Takuro

AU - Ohishi, Yoshihiro

AU - Oda, Yoshinao

AU - Kato, Kiyoko

PY - 2018/12/1

Y1 - 2018/12/1

N2 - Background: To evaluate the prognostic outcome and surgical complications in patients with early-stage cervical cancer who underwent sentinel node navigation surgery (SNNS) for hysterectomy or trachelectomy. Methods: A total of 139 patients who underwent SNNS using 99mTc phytate between 2009 and 2015 were evaluated. No further lymph node dissection was performed when intraoperative analysis of the sentinel lymph nodes (SLNs) was negative for metastasis. We compared the surgical complications between the SNNS group and 67 matched patients who underwent pelvic lymph node dissection (PLND) after SLN mapping between 2003 and 2008. We also examined the clinical outcomes in the SNNS group. Results: The mean number of detected SLNs was 2.5 per patient. Fourteen of the 139 patients in the SNNS group underwent PLND based on the intraoperative SLN results. The amount of blood loss, the operative time, and the number of perioperative complications were significantly less in the SNNS group than in the matched PLND group. There was no recurrence during a follow-up period ranging from 2 to 88 months (median 40 months) in the SNNS group. Conclusions: Using SNNS for early-stage cervical cancer is safe and effective and does not increase the recurrence rate. A future multicenter trial is warranted.

AB - Background: To evaluate the prognostic outcome and surgical complications in patients with early-stage cervical cancer who underwent sentinel node navigation surgery (SNNS) for hysterectomy or trachelectomy. Methods: A total of 139 patients who underwent SNNS using 99mTc phytate between 2009 and 2015 were evaluated. No further lymph node dissection was performed when intraoperative analysis of the sentinel lymph nodes (SLNs) was negative for metastasis. We compared the surgical complications between the SNNS group and 67 matched patients who underwent pelvic lymph node dissection (PLND) after SLN mapping between 2003 and 2008. We also examined the clinical outcomes in the SNNS group. Results: The mean number of detected SLNs was 2.5 per patient. Fourteen of the 139 patients in the SNNS group underwent PLND based on the intraoperative SLN results. The amount of blood loss, the operative time, and the number of perioperative complications were significantly less in the SNNS group than in the matched PLND group. There was no recurrence during a follow-up period ranging from 2 to 88 months (median 40 months) in the SNNS group. Conclusions: Using SNNS for early-stage cervical cancer is safe and effective and does not increase the recurrence rate. A future multicenter trial is warranted.

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