Prognostic significance of a minute amount of ascites during chemoradiotherapy for locally advanced pancreatic cancer

Makoto Shinoto, Katsumasa Nakamura, Yoshiyuki Shioyama, Tomonari Sasaki, Akihiro Nishie, Yoshiki Asayama, Saiji Ohga, Tadamasa Yoshitake, Kotaro Terashima, Kaori Asai, Keiji Matsumoto, Hiroshi Honda

Research output: Contribution to journalArticle

Abstract

Aim: The aim of this study was to investigate the clinical factors for predicting overall survival (OS) and the significance of a minute amount of ascites on computed tomography (CT) in patients with locally advanced pancreatic cancer (LAPC) treated with chemoradiotherapy (CRT). Patients and Methods: Between 2003 and 2011, 48 consecutive patients with LAPC were treated with CRT. Various clinical factors, including ascites, were evaluated for correlation with OS. A subset analysis of 16 patients with a minute amount of ascites was also performed. Results: The median survival duration and the 1-year OS rates were 11.5 months and 50%, respectively. A minute amount of ascites on CT and elevated carbohydrate antigen 19-9 (CA19-9) level were significantly associated with poorer OS. In 16 patients with ascites, the amount of ascites increased in the course of the disease, and these were considered to be cancerous clinically, regardless of the amount. Conclusion: A minute amount of ascites and CA19-9 were important prognostic factors in CRT. Any amount of ascites was considered an early indicator of peritoneal carcinomatosis in LAPC.

Original languageEnglish
Pages (from-to)1879-1884
Number of pages6
JournalAnticancer research
Volume36
Issue number4
Publication statusPublished - Apr 2016

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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