TY - JOUR
T1 - Prognostic significance of microvessel density, vascular cuffing and vascular endothelial growth factor expression in ovarian carcinoma
T2 - A special review for clear cell adenocarcinoma
AU - Ogawa, Shinji
AU - Kaku, Tsunehisa
AU - Kobayashi, Hiroaki
AU - Hirakawa, Toshio
AU - Ohishi, Yoshihiro
AU - Kinukawa, Naoko
AU - Nakano, Hitoo
N1 - Funding Information:
This work was supported in part by Grants-in-Aid for Scientific Research (C) from the Ministry of Education, Culture, Sports, Science and Technolgy (Nos. 11671626, 12671612, 12671613).
PY - 2002/2/8
Y1 - 2002/2/8
N2 - Our purpose is to demonstrate the relationship between microvessel density (MVD), vascular cuffing (VC), vascular endothelial growth factor (VEGF) expression and clinicopathological parameters in ovarian cancer. Surgical specimens from 105 primary ovarian cancers were examined for vascularization and VEGF expression by immunohistochemical staining. The higher MVD group (MVD ≥ 70) and the positive VEGF group were associated with better progression-free survival only in early stages. The significant association of the MVD with better progression-free survival was recognized only in the patients with clear cell adenocarcinomas. The complete VC group showed a similar trend as MVD though there was no statistical difference. A multivariate analysis revealed MVD to correlate independently with progression-free survival. In ovarian carcinoma, MVD was found to be an independent prognostic factor. In addition, the higher MVD with clear cell adenocarcinoma had the better prognosis. The clinicopathological role of angiogenesis should be analyzed taking account of histologic type.
AB - Our purpose is to demonstrate the relationship between microvessel density (MVD), vascular cuffing (VC), vascular endothelial growth factor (VEGF) expression and clinicopathological parameters in ovarian cancer. Surgical specimens from 105 primary ovarian cancers were examined for vascularization and VEGF expression by immunohistochemical staining. The higher MVD group (MVD ≥ 70) and the positive VEGF group were associated with better progression-free survival only in early stages. The significant association of the MVD with better progression-free survival was recognized only in the patients with clear cell adenocarcinomas. The complete VC group showed a similar trend as MVD though there was no statistical difference. A multivariate analysis revealed MVD to correlate independently with progression-free survival. In ovarian carcinoma, MVD was found to be an independent prognostic factor. In addition, the higher MVD with clear cell adenocarcinoma had the better prognosis. The clinicopathological role of angiogenesis should be analyzed taking account of histologic type.
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U2 - 10.1016/S0304-3835(01)00754-6
DO - 10.1016/S0304-3835(01)00754-6
M3 - Article
C2 - 11790460
AN - SCOPUS:0037039719
SN - 0304-3835
VL - 176
SP - 111
EP - 118
JO - Cancer Letters
JF - Cancer Letters
IS - 1
ER -
