Prognostic significance of microvessel density, vascular cuffing and vascular endothelial growth factor expression in ovarian carcinoma: A special review for clear cell adenocarcinoma

Shinji Ogawa, Tsunehisa Kaku, Hiroaki Kobayashi, Toshio Hirakawa, Yoshihiro Ohishi, Naoko Kinukawa, Hitoo Nakano

Research output: Contribution to journalArticlepeer-review

58 Citations (Scopus)

Abstract

Our purpose is to demonstrate the relationship between microvessel density (MVD), vascular cuffing (VC), vascular endothelial growth factor (VEGF) expression and clinicopathological parameters in ovarian cancer. Surgical specimens from 105 primary ovarian cancers were examined for vascularization and VEGF expression by immunohistochemical staining. The higher MVD group (MVD ≥ 70) and the positive VEGF group were associated with better progression-free survival only in early stages. The significant association of the MVD with better progression-free survival was recognized only in the patients with clear cell adenocarcinomas. The complete VC group showed a similar trend as MVD though there was no statistical difference. A multivariate analysis revealed MVD to correlate independently with progression-free survival. In ovarian carcinoma, MVD was found to be an independent prognostic factor. In addition, the higher MVD with clear cell adenocarcinoma had the better prognosis. The clinicopathological role of angiogenesis should be analyzed taking account of histologic type.

Original languageEnglish
Pages (from-to)111-118
Number of pages8
JournalCancer Letters
Volume176
Issue number1
DOIs
Publication statusPublished - Feb 8 2002

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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