TY - JOUR
T1 - Prognostic Significance of Systemic Inflammatory Response in Cases of Temporal Bone Squamous Cell Carcinoma
AU - Komune, Noritaka
AU - Sato, Kuniaki
AU - Hongo, Takahiro
AU - Miyazaki, Masaru
AU - Masuda, Shogo
AU - Koike, Kensuke
AU - Uchi, Ryutaro
AU - Tsuchihashi, Nana Akagi
AU - Noda, Teppei
AU - Kogo, Ryunosuke
AU - Wakasaki, Takahiro
AU - Yasumatsu, Ryuji
AU - Nakagawa, Takashi
N1 - Funding Information:
This work was supported in part by the JSPS KAKENHI (Grant numbers JP 18H02951 and 18K16895).
Publisher Copyright:
© 2021 The American Laryngological, Rhinological and Otological Society, Inc.
PY - 2021/8
Y1 - 2021/8
N2 - Objective/Hypothesis: Squamous cell carcinoma (SCC) of the temporal bone is an extremely rare condition. This rarity has led to a delay in the establishment of a standard treatment protocol and adequate staging system. Identification of prognostic markers of this disease from a variety of fields is desirable in the establishment of treatment guidelines for temporal bone SCC. The aim of this study is to assess the prognostic role of inflammation-based prognostic scores in cases of temporal bone SCC. Study Design: Case reries with chart review. Methods: A total of 71 cases of primary malignancy eligible for curative treatment at a single tertiary medical institute were retrospectively analyzed. Univariate and multivariate regression analyzes were used to investigate the association between the inflammation-based scores and 5-year overall survival. Results: Univariate Cox regression analyzes showed that a high neutrophil-to-lymphocyte ratio, high platelet-to-lymphocyte ratio, low lymphocyte-to-monocyte ratio, a Glasgow prognostic score of 2, and the systemic inflammation score of 2 were significantly associated with a poor prognosis, as well as a classification of T4 stage, presence of cervical lymph node metastasis, high white blood cell counts, and high C-reactive protein levels. The multivariate analysis showed that a clinical stage of T4 and a systemic inflammation score of 2 were independent prognostic markers. Conclusions: Inflammation-based prognostic markers are associated with the survival of patients with temporal bone SCC, as well as other head and neck SCCs. Level of Evidence: 4 Laryngoscope, 131:1782–1789, 2021.
AB - Objective/Hypothesis: Squamous cell carcinoma (SCC) of the temporal bone is an extremely rare condition. This rarity has led to a delay in the establishment of a standard treatment protocol and adequate staging system. Identification of prognostic markers of this disease from a variety of fields is desirable in the establishment of treatment guidelines for temporal bone SCC. The aim of this study is to assess the prognostic role of inflammation-based prognostic scores in cases of temporal bone SCC. Study Design: Case reries with chart review. Methods: A total of 71 cases of primary malignancy eligible for curative treatment at a single tertiary medical institute were retrospectively analyzed. Univariate and multivariate regression analyzes were used to investigate the association between the inflammation-based scores and 5-year overall survival. Results: Univariate Cox regression analyzes showed that a high neutrophil-to-lymphocyte ratio, high platelet-to-lymphocyte ratio, low lymphocyte-to-monocyte ratio, a Glasgow prognostic score of 2, and the systemic inflammation score of 2 were significantly associated with a poor prognosis, as well as a classification of T4 stage, presence of cervical lymph node metastasis, high white blood cell counts, and high C-reactive protein levels. The multivariate analysis showed that a clinical stage of T4 and a systemic inflammation score of 2 were independent prognostic markers. Conclusions: Inflammation-based prognostic markers are associated with the survival of patients with temporal bone SCC, as well as other head and neck SCCs. Level of Evidence: 4 Laryngoscope, 131:1782–1789, 2021.
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U2 - 10.1002/lary.29421
DO - 10.1002/lary.29421
M3 - Article
C2 - 33538330
AN - SCOPUS:85100470470
VL - 131
SP - 1782
EP - 1789
JO - Laryngoscope
JF - Laryngoscope
SN - 0023-852X
IS - 8
ER -