Prognostic significance of tumor markers in peritoneal lavage in advanced gastric cancer

Manabu Yamamoto, Hideo Baba, Yoshihiro Kakeji, Kazuya Endo, Yasuharu Ikeda, Yasushi Toh, Shunji Kohnoe, Takeshi Okamura, Yoshihiko Maehara

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Objective: Predicting peritoneal dissemination of cancer is very difficult whatever method of examination is used. Recently, a cytological examination of peritoneal lavage has been shown to be a feasible measure to predict an early state of peritoneal seeding. The predictive value of the levels of tumor markers in peritoneal lavage for peritoneal metastasis from gastric carcinoma was thus studied. Methods: In 229 patients gastric cancer tumor markers, CEA, CA 125, and CA 19-9, in peritoneal lavage were intraoperatively evaluated using a chemiluminescent enzyme immunoassay. Results: CEA in peritoneal lavage at a cutoff level of 0.5 ng/ml showed overall a higher sensitivity of 75.8% at a specificity of 90.8% for a diagnosis of peritoneal dissemination including cytologically positive peritoneal lavage [CY(+)] than CA 125 or CA 19-9 in peritoneal lavage. The CEA level in peritoneal lavage as well as both serosal invasion and the CA 125 level in peritoneal lavage were significant factors for the prediction of peritoneal dissemination including CY(+) with a relative risk of 6.6, 14.1 and 9.4. In patients undergoing curative operations, the recurrence rate for peritoneal dissemination and liver metastasis in cases with CEA levels in peritoneal lavage of ≥0.5 ng/ml was significantly higher than that in cases with CEA levels of <0.5 ng/ml (p < 0.0001, p < 0.002). Conclusions: These finding suggest that the CEA level in peritoneal lavage is thus considered to be a predictor of peritoneal dissemination including CY(+).

Original languageEnglish
Pages (from-to)19-26
Number of pages8
JournalOncology
Volume67
Issue number1
DOIs
Publication statusPublished - Oct 27 2004

Fingerprint

Peritoneal Lavage
Tumor Biomarkers
Stomach Neoplasms
Neoplasm Metastasis
Immunoenzyme Techniques
Stomach
Carcinoma

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Yamamoto, M., Baba, H., Kakeji, Y., Endo, K., Ikeda, Y., Toh, Y., ... Maehara, Y. (2004). Prognostic significance of tumor markers in peritoneal lavage in advanced gastric cancer. Oncology, 67(1), 19-26. https://doi.org/10.1159/000080281

Prognostic significance of tumor markers in peritoneal lavage in advanced gastric cancer. / Yamamoto, Manabu; Baba, Hideo; Kakeji, Yoshihiro; Endo, Kazuya; Ikeda, Yasuharu; Toh, Yasushi; Kohnoe, Shunji; Okamura, Takeshi; Maehara, Yoshihiko.

In: Oncology, Vol. 67, No. 1, 27.10.2004, p. 19-26.

Research output: Contribution to journalArticle

Yamamoto, M, Baba, H, Kakeji, Y, Endo, K, Ikeda, Y, Toh, Y, Kohnoe, S, Okamura, T & Maehara, Y 2004, 'Prognostic significance of tumor markers in peritoneal lavage in advanced gastric cancer', Oncology, vol. 67, no. 1, pp. 19-26. https://doi.org/10.1159/000080281
Yamamoto M, Baba H, Kakeji Y, Endo K, Ikeda Y, Toh Y et al. Prognostic significance of tumor markers in peritoneal lavage in advanced gastric cancer. Oncology. 2004 Oct 27;67(1):19-26. https://doi.org/10.1159/000080281
Yamamoto, Manabu ; Baba, Hideo ; Kakeji, Yoshihiro ; Endo, Kazuya ; Ikeda, Yasuharu ; Toh, Yasushi ; Kohnoe, Shunji ; Okamura, Takeshi ; Maehara, Yoshihiko. / Prognostic significance of tumor markers in peritoneal lavage in advanced gastric cancer. In: Oncology. 2004 ; Vol. 67, No. 1. pp. 19-26.
@article{ea0adcf1d8d746e08879f34b1a93b9b8,
title = "Prognostic significance of tumor markers in peritoneal lavage in advanced gastric cancer",
abstract = "Objective: Predicting peritoneal dissemination of cancer is very difficult whatever method of examination is used. Recently, a cytological examination of peritoneal lavage has been shown to be a feasible measure to predict an early state of peritoneal seeding. The predictive value of the levels of tumor markers in peritoneal lavage for peritoneal metastasis from gastric carcinoma was thus studied. Methods: In 229 patients gastric cancer tumor markers, CEA, CA 125, and CA 19-9, in peritoneal lavage were intraoperatively evaluated using a chemiluminescent enzyme immunoassay. Results: CEA in peritoneal lavage at a cutoff level of 0.5 ng/ml showed overall a higher sensitivity of 75.8{\%} at a specificity of 90.8{\%} for a diagnosis of peritoneal dissemination including cytologically positive peritoneal lavage [CY(+)] than CA 125 or CA 19-9 in peritoneal lavage. The CEA level in peritoneal lavage as well as both serosal invasion and the CA 125 level in peritoneal lavage were significant factors for the prediction of peritoneal dissemination including CY(+) with a relative risk of 6.6, 14.1 and 9.4. In patients undergoing curative operations, the recurrence rate for peritoneal dissemination and liver metastasis in cases with CEA levels in peritoneal lavage of ≥0.5 ng/ml was significantly higher than that in cases with CEA levels of <0.5 ng/ml (p < 0.0001, p < 0.002). Conclusions: These finding suggest that the CEA level in peritoneal lavage is thus considered to be a predictor of peritoneal dissemination including CY(+).",
author = "Manabu Yamamoto and Hideo Baba and Yoshihiro Kakeji and Kazuya Endo and Yasuharu Ikeda and Yasushi Toh and Shunji Kohnoe and Takeshi Okamura and Yoshihiko Maehara",
year = "2004",
month = "10",
day = "27",
doi = "10.1159/000080281",
language = "English",
volume = "67",
pages = "19--26",
journal = "Oncology",
issn = "0030-2414",
publisher = "S. Karger AG",
number = "1",

}

TY - JOUR

T1 - Prognostic significance of tumor markers in peritoneal lavage in advanced gastric cancer

AU - Yamamoto, Manabu

AU - Baba, Hideo

AU - Kakeji, Yoshihiro

AU - Endo, Kazuya

AU - Ikeda, Yasuharu

AU - Toh, Yasushi

AU - Kohnoe, Shunji

AU - Okamura, Takeshi

AU - Maehara, Yoshihiko

PY - 2004/10/27

Y1 - 2004/10/27

N2 - Objective: Predicting peritoneal dissemination of cancer is very difficult whatever method of examination is used. Recently, a cytological examination of peritoneal lavage has been shown to be a feasible measure to predict an early state of peritoneal seeding. The predictive value of the levels of tumor markers in peritoneal lavage for peritoneal metastasis from gastric carcinoma was thus studied. Methods: In 229 patients gastric cancer tumor markers, CEA, CA 125, and CA 19-9, in peritoneal lavage were intraoperatively evaluated using a chemiluminescent enzyme immunoassay. Results: CEA in peritoneal lavage at a cutoff level of 0.5 ng/ml showed overall a higher sensitivity of 75.8% at a specificity of 90.8% for a diagnosis of peritoneal dissemination including cytologically positive peritoneal lavage [CY(+)] than CA 125 or CA 19-9 in peritoneal lavage. The CEA level in peritoneal lavage as well as both serosal invasion and the CA 125 level in peritoneal lavage were significant factors for the prediction of peritoneal dissemination including CY(+) with a relative risk of 6.6, 14.1 and 9.4. In patients undergoing curative operations, the recurrence rate for peritoneal dissemination and liver metastasis in cases with CEA levels in peritoneal lavage of ≥0.5 ng/ml was significantly higher than that in cases with CEA levels of <0.5 ng/ml (p < 0.0001, p < 0.002). Conclusions: These finding suggest that the CEA level in peritoneal lavage is thus considered to be a predictor of peritoneal dissemination including CY(+).

AB - Objective: Predicting peritoneal dissemination of cancer is very difficult whatever method of examination is used. Recently, a cytological examination of peritoneal lavage has been shown to be a feasible measure to predict an early state of peritoneal seeding. The predictive value of the levels of tumor markers in peritoneal lavage for peritoneal metastasis from gastric carcinoma was thus studied. Methods: In 229 patients gastric cancer tumor markers, CEA, CA 125, and CA 19-9, in peritoneal lavage were intraoperatively evaluated using a chemiluminescent enzyme immunoassay. Results: CEA in peritoneal lavage at a cutoff level of 0.5 ng/ml showed overall a higher sensitivity of 75.8% at a specificity of 90.8% for a diagnosis of peritoneal dissemination including cytologically positive peritoneal lavage [CY(+)] than CA 125 or CA 19-9 in peritoneal lavage. The CEA level in peritoneal lavage as well as both serosal invasion and the CA 125 level in peritoneal lavage were significant factors for the prediction of peritoneal dissemination including CY(+) with a relative risk of 6.6, 14.1 and 9.4. In patients undergoing curative operations, the recurrence rate for peritoneal dissemination and liver metastasis in cases with CEA levels in peritoneal lavage of ≥0.5 ng/ml was significantly higher than that in cases with CEA levels of <0.5 ng/ml (p < 0.0001, p < 0.002). Conclusions: These finding suggest that the CEA level in peritoneal lavage is thus considered to be a predictor of peritoneal dissemination including CY(+).

UR - http://www.scopus.com/inward/record.url?scp=5644254187&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=5644254187&partnerID=8YFLogxK

U2 - 10.1159/000080281

DO - 10.1159/000080281

M3 - Article

C2 - 15459491

AN - SCOPUS:5644254187

VL - 67

SP - 19

EP - 26

JO - Oncology

JF - Oncology

SN - 0030-2414

IS - 1

ER -