Prognostic value of an inflammation-based score in patients undergoing pre-operative chemotherapy followed by surgery for esophageal cancer

Hiroshi Miyata, Makoto Yamasaki, Yukinori Kurokawa, Shuji Takiguchi, Kiyokazu Nakajima, Yoshiyuki Fujiwara, Masaki Mori, Yuichiro Doki

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28 Citations (Scopus)

Abstract

Recent studies have shown that the presence of systemic inflammation is associated with poor outcome in patients with malignancy. However, whether systemic inflammation affects the response to pre-operative therapy and survival of patients undergoing multimodal treatment for esophageal cancer is not clear. We studied 152 patients who underwent pre-operative chemotherapy followed by surgery for esophageal cancer. The correlation between various clinicopathological factors, including hematological markers of systemic inflammatory response, and survival or response to chemotherapy was examined. Among various hematological factors, leucocyte count, hemoglobin level, albumin level, neutrophil-lymphocyte ratio and CEA, but not serum concentration of C-reactive protein, were significantly associated with survival. Multivariate analysis revealed that the clinical response to chemotherapy, number of metastatic lymph nodes, operative complications and systemic inflammation score (SI score), comprising leucocyte count, albumin and hemoglobin levels, were independent prognostic factors, and identified the SI score as the most significant prognostic factor. There was no significant relationship between hematological markers of systemic inflammation, including the SI score, and the response to chemotherapy. In conclusion, in patients scheduled for chemotherapy followed by surgery for esophageal cancer, systemic inflammation, reflected by SI, predicts poor outcome, but not the response to chemotherapy.

Original languageEnglish
Pages (from-to)879-885
Number of pages7
JournalExperimental and Therapeutic Medicine
Volume2
Issue number5
DOIs
Publication statusPublished - Sep 1 2011

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Esophageal Neoplasms
Inflammation
Drug Therapy
Leukocyte Count
Survival
Albumins
Hemoglobins
Combined Modality Therapy
C-Reactive Protein
Neutrophils
Multivariate Analysis
Lymph Nodes
Lymphocytes
Serum
Neoplasms

All Science Journal Classification (ASJC) codes

  • Immunology and Microbiology (miscellaneous)
  • Cancer Research

Cite this

Prognostic value of an inflammation-based score in patients undergoing pre-operative chemotherapy followed by surgery for esophageal cancer. / Miyata, Hiroshi; Yamasaki, Makoto; Kurokawa, Yukinori; Takiguchi, Shuji; Nakajima, Kiyokazu; Fujiwara, Yoshiyuki; Mori, Masaki; Doki, Yuichiro.

In: Experimental and Therapeutic Medicine, Vol. 2, No. 5, 01.09.2011, p. 879-885.

Research output: Contribution to journalArticle

Miyata, Hiroshi ; Yamasaki, Makoto ; Kurokawa, Yukinori ; Takiguchi, Shuji ; Nakajima, Kiyokazu ; Fujiwara, Yoshiyuki ; Mori, Masaki ; Doki, Yuichiro. / Prognostic value of an inflammation-based score in patients undergoing pre-operative chemotherapy followed by surgery for esophageal cancer. In: Experimental and Therapeutic Medicine. 2011 ; Vol. 2, No. 5. pp. 879-885.
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