Prognostic value of cathepsin L and its inhibitor headpin in oral squamous cell carcinoma

Torahiko Nakashima, Ryuji Yasumatsu, M. Masuda, G. L. Clayman, S. Komune

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Objective: To investigate the clinicopathological and prognostic significance of the expression of cathepsin L and its inhibitor headpin, in oral squamous cell carcinoma. Design: Immunohistochemical studies were performed on 56 oral squamous cell carcinoma samples. We evaluated the relationship between cathepsin L and headpin expression versus patients' clinicopathological factors and survival. Results: The group that was positive for cathepsin L expression tended to have positive metastatic neck lymph nodes and a poorer prognosis. Headpin expression was not related to metastasis or prognosis. Well differentiated squamous cell carcinoma had higher levels of headpin expression compared with poorly differentiated squamous cell carcinoma. Conclusion: Cathepsin L expression is related to the invasive and metastatic potential of oral squamous cell carcinoma.

Original languageEnglish
Pages (from-to)1134-1137
Number of pages4
JournalJournal of Laryngology and Otology
Volume126
Issue number11
DOIs
Publication statusPublished - Nov 1 2012

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Cathepsin L
Squamous Cell Carcinoma
Neck
Lymph Nodes
Neoplasm Metastasis
Survival

All Science Journal Classification (ASJC) codes

  • Otorhinolaryngology

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Prognostic value of cathepsin L and its inhibitor headpin in oral squamous cell carcinoma. / Nakashima, Torahiko; Yasumatsu, Ryuji; Masuda, M.; Clayman, G. L.; Komune, S.

In: Journal of Laryngology and Otology, Vol. 126, No. 11, 01.11.2012, p. 1134-1137.

Research output: Contribution to journalArticle

Nakashima, Torahiko ; Yasumatsu, Ryuji ; Masuda, M. ; Clayman, G. L. ; Komune, S. / Prognostic value of cathepsin L and its inhibitor headpin in oral squamous cell carcinoma. In: Journal of Laryngology and Otology. 2012 ; Vol. 126, No. 11. pp. 1134-1137.
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