Abstract
Aims: The objective of this study was to investigate the incidence and clinical significance of lymphoma-associated chromosomal translocations, particularly those involving the immunoglobulin heavy chain gene (IGH) locus, in patients with small-bowel diffuse large B-cell lymphoma (DLBCL). Methods and results: Translocations involving IGH, bcl-6, MYC and bcl-2 were investigated with interphase fluorescence in-situ hybridization on paraffin-embedded tissues in 35 patients with primary small-bowel DLBCL, and the overall survival (OS) and progression-free survival (PFS) rates were evaluated with the Kaplan-Meier method. Translocations involving IGH, bcl-6, MYC and bcl-2 were detected in 23 (70%), 12 (36%), eight (24%) and six (18%) of 33 cases, respectively. The patients with IGH translocations showed less frequent relapse or progression of lymphoma (17%) than those without (60%, P = 0.034). Univariate analyses demonstrated that young age, a low international prognostic index, translocations involving IGH, extra copies of MALT1/bcl-2 and bcl-6 immunoexpression were significantly associated with better OS and PFS. Cox multivariate analysis revealed translocations involving IGH to constitute an independent prognostic factor for better PFS, but not better OS. Conclusions: Translocations involving IGH are frequent in cases of small-bowel DLBCL. These translocations may be predictive of a favourable clinical course.
| Original language | English |
|---|---|
| Pages (from-to) | 199-209 |
| Number of pages | 11 |
| Journal | Histopathology |
| Volume | 68 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Jan 1 2016 |
Fingerprint
All Science Journal Classification (ASJC) codes
- Pathology and Forensic Medicine
- Histology
Cite this
Prognostic value of chromosomal translocations in small-bowel diffuse large B-cell lymphoma. / Ikegami, Koji; Nakamura, Shotaro; Esaki, Motohiro; Yanai, Shunichi; Hirahashi, Minako; Oda, Yoshinao; Takeshita, Morishige; Matsumoto, Takayuki; Kitazono, Takanari.
In: Histopathology, Vol. 68, No. 2, 01.01.2016, p. 199-209.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Prognostic value of chromosomal translocations in small-bowel diffuse large B-cell lymphoma
AU - Ikegami, Koji
AU - Nakamura, Shotaro
AU - Esaki, Motohiro
AU - Yanai, Shunichi
AU - Hirahashi, Minako
AU - Oda, Yoshinao
AU - Takeshita, Morishige
AU - Matsumoto, Takayuki
AU - Kitazono, Takanari
PY - 2016/1/1
Y1 - 2016/1/1
N2 - Aims: The objective of this study was to investigate the incidence and clinical significance of lymphoma-associated chromosomal translocations, particularly those involving the immunoglobulin heavy chain gene (IGH) locus, in patients with small-bowel diffuse large B-cell lymphoma (DLBCL). Methods and results: Translocations involving IGH, bcl-6, MYC and bcl-2 were investigated with interphase fluorescence in-situ hybridization on paraffin-embedded tissues in 35 patients with primary small-bowel DLBCL, and the overall survival (OS) and progression-free survival (PFS) rates were evaluated with the Kaplan-Meier method. Translocations involving IGH, bcl-6, MYC and bcl-2 were detected in 23 (70%), 12 (36%), eight (24%) and six (18%) of 33 cases, respectively. The patients with IGH translocations showed less frequent relapse or progression of lymphoma (17%) than those without (60%, P = 0.034). Univariate analyses demonstrated that young age, a low international prognostic index, translocations involving IGH, extra copies of MALT1/bcl-2 and bcl-6 immunoexpression were significantly associated with better OS and PFS. Cox multivariate analysis revealed translocations involving IGH to constitute an independent prognostic factor for better PFS, but not better OS. Conclusions: Translocations involving IGH are frequent in cases of small-bowel DLBCL. These translocations may be predictive of a favourable clinical course.
AB - Aims: The objective of this study was to investigate the incidence and clinical significance of lymphoma-associated chromosomal translocations, particularly those involving the immunoglobulin heavy chain gene (IGH) locus, in patients with small-bowel diffuse large B-cell lymphoma (DLBCL). Methods and results: Translocations involving IGH, bcl-6, MYC and bcl-2 were investigated with interphase fluorescence in-situ hybridization on paraffin-embedded tissues in 35 patients with primary small-bowel DLBCL, and the overall survival (OS) and progression-free survival (PFS) rates were evaluated with the Kaplan-Meier method. Translocations involving IGH, bcl-6, MYC and bcl-2 were detected in 23 (70%), 12 (36%), eight (24%) and six (18%) of 33 cases, respectively. The patients with IGH translocations showed less frequent relapse or progression of lymphoma (17%) than those without (60%, P = 0.034). Univariate analyses demonstrated that young age, a low international prognostic index, translocations involving IGH, extra copies of MALT1/bcl-2 and bcl-6 immunoexpression were significantly associated with better OS and PFS. Cox multivariate analysis revealed translocations involving IGH to constitute an independent prognostic factor for better PFS, but not better OS. Conclusions: Translocations involving IGH are frequent in cases of small-bowel DLBCL. These translocations may be predictive of a favourable clinical course.
UR - http://www.scopus.com/inward/record.url?scp=84955204929&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84955204929&partnerID=8YFLogxK
U2 - 10.1111/his.12731
DO - 10.1111/his.12731
M3 - Article
C2 - 25953462
AN - SCOPUS:84955204929
VL - 68
SP - 199
EP - 209
JO - Histopathology
JF - Histopathology
SN - 0309-0167
IS - 2
ER -