Prognostic value of intraoperative pleural lavage cytology for non-small cell lung cancer: The influence of positive pleural lavage cytology results on T classification

Kotaro Kameyama, Norihito Okumura, Etsuo Miyaoka, Hisao Asamura, Ichiro Yoshino, Hirohito Tada, Yoshitaka Fujii, Yoichi Nakanishi, Kenji Eguchi, Masaki Mori, Hideo Kobayashi, Noriyoshi Sawabata, Meinoshin Okumura, Kohei Yokoi

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Results A total of 217 patients (5.2%) were PLC-positive, which was significantly associated with a higher incidence of adenocarcinoma and advanced disease. The 5-year survival for patients with positive and negative PLC results were 44.5% and 72.8%, respectively, and this difference in survival was statistically significant (P <.001). Multivariate analysis showed that positive PLC status was an independent factor for a poor prognosis (hazard ratio, 1.57; P <.001). Significant differences in survival were also found between patients with positive and negative PLC results in the same T categories and stages, including T2a, T3, stage IB, and stage IIIA. The IPLCC recommendations adjusted the prognostic differences in all T categories and stages. The significant difference in survival disappeared between the 2 groups in all T categories and stages.

Conclusions Our results indicate that a T category upgrade is prognostically adequate for patients who are PLC-positive.

Objective Although positive pleural lavage cytology (PLC) has been demonstrated to be closely associated with a poor prognosis for patients with lung cancer, it has not been incorporated into the TNM staging system of the Union for International Cancer Control. The aim of our study was to retrospectively examine the clinical significance of PLC status and illustrate the recommendations of the International Pleural Lavage Cytology Collaborators (IPLCC) in a large national database.

Original languageEnglish
Pages (from-to)2659-2664
Number of pages6
JournalJournal of Thoracic and Cardiovascular Surgery
Volume148
Issue number6
DOIs
Publication statusPublished - Dec 1 2014

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Therapeutic Irrigation
Non-Small Cell Lung Carcinoma
Cell Biology
Survival
Neoplasm Staging
Lung Neoplasms
Adenocarcinoma
Multivariate Analysis
Databases
Incidence

All Science Journal Classification (ASJC) codes

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine

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Prognostic value of intraoperative pleural lavage cytology for non-small cell lung cancer : The influence of positive pleural lavage cytology results on T classification. / Kameyama, Kotaro; Okumura, Norihito; Miyaoka, Etsuo; Asamura, Hisao; Yoshino, Ichiro; Tada, Hirohito; Fujii, Yoshitaka; Nakanishi, Yoichi; Eguchi, Kenji; Mori, Masaki; Kobayashi, Hideo; Sawabata, Noriyoshi; Okumura, Meinoshin; Yokoi, Kohei.

In: Journal of Thoracic and Cardiovascular Surgery, Vol. 148, No. 6, 01.12.2014, p. 2659-2664.

Research output: Contribution to journalArticle

Kameyama, K, Okumura, N, Miyaoka, E, Asamura, H, Yoshino, I, Tada, H, Fujii, Y, Nakanishi, Y, Eguchi, K, Mori, M, Kobayashi, H, Sawabata, N, Okumura, M & Yokoi, K 2014, 'Prognostic value of intraoperative pleural lavage cytology for non-small cell lung cancer: The influence of positive pleural lavage cytology results on T classification', Journal of Thoracic and Cardiovascular Surgery, vol. 148, no. 6, pp. 2659-2664. https://doi.org/10.1016/j.jtcvs.2014.07.090
Kameyama, Kotaro ; Okumura, Norihito ; Miyaoka, Etsuo ; Asamura, Hisao ; Yoshino, Ichiro ; Tada, Hirohito ; Fujii, Yoshitaka ; Nakanishi, Yoichi ; Eguchi, Kenji ; Mori, Masaki ; Kobayashi, Hideo ; Sawabata, Noriyoshi ; Okumura, Meinoshin ; Yokoi, Kohei. / Prognostic value of intraoperative pleural lavage cytology for non-small cell lung cancer : The influence of positive pleural lavage cytology results on T classification. In: Journal of Thoracic and Cardiovascular Surgery. 2014 ; Vol. 148, No. 6. pp. 2659-2664.
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abstract = "Results A total of 217 patients (5.2{\%}) were PLC-positive, which was significantly associated with a higher incidence of adenocarcinoma and advanced disease. The 5-year survival for patients with positive and negative PLC results were 44.5{\%} and 72.8{\%}, respectively, and this difference in survival was statistically significant (P <.001). Multivariate analysis showed that positive PLC status was an independent factor for a poor prognosis (hazard ratio, 1.57; P <.001). Significant differences in survival were also found between patients with positive and negative PLC results in the same T categories and stages, including T2a, T3, stage IB, and stage IIIA. The IPLCC recommendations adjusted the prognostic differences in all T categories and stages. The significant difference in survival disappeared between the 2 groups in all T categories and stages.Conclusions Our results indicate that a T category upgrade is prognostically adequate for patients who are PLC-positive.Objective Although positive pleural lavage cytology (PLC) has been demonstrated to be closely associated with a poor prognosis for patients with lung cancer, it has not been incorporated into the TNM staging system of the Union for International Cancer Control. The aim of our study was to retrospectively examine the clinical significance of PLC status and illustrate the recommendations of the International Pleural Lavage Cytology Collaborators (IPLCC) in a large national database.",
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T1 - Prognostic value of intraoperative pleural lavage cytology for non-small cell lung cancer

T2 - The influence of positive pleural lavage cytology results on T classification

AU - Kameyama, Kotaro

AU - Okumura, Norihito

AU - Miyaoka, Etsuo

AU - Asamura, Hisao

AU - Yoshino, Ichiro

AU - Tada, Hirohito

AU - Fujii, Yoshitaka

AU - Nakanishi, Yoichi

AU - Eguchi, Kenji

AU - Mori, Masaki

AU - Kobayashi, Hideo

AU - Sawabata, Noriyoshi

AU - Okumura, Meinoshin

AU - Yokoi, Kohei

PY - 2014/12/1

Y1 - 2014/12/1

N2 - Results A total of 217 patients (5.2%) were PLC-positive, which was significantly associated with a higher incidence of adenocarcinoma and advanced disease. The 5-year survival for patients with positive and negative PLC results were 44.5% and 72.8%, respectively, and this difference in survival was statistically significant (P <.001). Multivariate analysis showed that positive PLC status was an independent factor for a poor prognosis (hazard ratio, 1.57; P <.001). Significant differences in survival were also found between patients with positive and negative PLC results in the same T categories and stages, including T2a, T3, stage IB, and stage IIIA. The IPLCC recommendations adjusted the prognostic differences in all T categories and stages. The significant difference in survival disappeared between the 2 groups in all T categories and stages.Conclusions Our results indicate that a T category upgrade is prognostically adequate for patients who are PLC-positive.Objective Although positive pleural lavage cytology (PLC) has been demonstrated to be closely associated with a poor prognosis for patients with lung cancer, it has not been incorporated into the TNM staging system of the Union for International Cancer Control. The aim of our study was to retrospectively examine the clinical significance of PLC status and illustrate the recommendations of the International Pleural Lavage Cytology Collaborators (IPLCC) in a large national database.

AB - Results A total of 217 patients (5.2%) were PLC-positive, which was significantly associated with a higher incidence of adenocarcinoma and advanced disease. The 5-year survival for patients with positive and negative PLC results were 44.5% and 72.8%, respectively, and this difference in survival was statistically significant (P <.001). Multivariate analysis showed that positive PLC status was an independent factor for a poor prognosis (hazard ratio, 1.57; P <.001). Significant differences in survival were also found between patients with positive and negative PLC results in the same T categories and stages, including T2a, T3, stage IB, and stage IIIA. The IPLCC recommendations adjusted the prognostic differences in all T categories and stages. The significant difference in survival disappeared between the 2 groups in all T categories and stages.Conclusions Our results indicate that a T category upgrade is prognostically adequate for patients who are PLC-positive.Objective Although positive pleural lavage cytology (PLC) has been demonstrated to be closely associated with a poor prognosis for patients with lung cancer, it has not been incorporated into the TNM staging system of the Union for International Cancer Control. The aim of our study was to retrospectively examine the clinical significance of PLC status and illustrate the recommendations of the International Pleural Lavage Cytology Collaborators (IPLCC) in a large national database.

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