Prognostic value of p53 protein expression for patients with gastric cancer: A multivariate analysis

Yoshihiko Maehara, M. Tomoda, S. Hasuda, Akira Kabashima, E. Tokunaga, Y. Kakeji, K. Sugimachi

Research output: Contribution to journalArticle

62 Citations (Scopus)

Abstract

Mutations in the p53 gene, one of the most common genetic alterations in human cancer, are implicated in tumorigenesis and tumour progression. Although p53 protein expression appears to be correlated to prognosis in patients with malignancy, its prognostic role in gastric cancer has remained controversial. We examined the clinical significance of p53 overexpression in 427 patients with gastric cancer, using multivariate analysis. Tumour sections of gastric cancer tissues from these 427 Japanese patients were stained immunohistochemically with monoclonal antibody PAb1801. The presence of p53 expression was statistically compared with clinicopathological features and postoperative survival, using univariate and muitivariate analyses. p53 expression was detected in 38.6% (165 out of 427) of these gastric cancers and immunoreactivity was not observed in normal mucosa adjacent to the tumour. A higher rate of p53 detection was observed among large tumours and in those with a prominent depth of invasion, lymphatic and vascular invasion and lymph node involvement. Prognosis was significantly worse for patients with p53-positive-staining tumours. The 5-year survival rate was 62.5% for patients with p53-negative tumours and 43.3% for those with positive malignancies. p53 expression was a significant prognostic factor for node-positive gastric cancers in subjects undergoing treatment with curative resection, as assessed by Cox regression analysis. Thus, the expression of p53 was closely related to the potential for tumour advance and a poorer post-operative prognosis for patients with gastric cancer.

Original languageEnglish
Pages (from-to)1255-1261
Number of pages7
JournalBritish journal of cancer
Volume79
Issue number7-8
DOIs
Publication statusPublished - Feb 28 1999

Fingerprint

Stomach Neoplasms
Multivariate Analysis
Neoplasms
Proteins
p53 Genes
Blood Vessels
Carcinogenesis
Mucous Membrane
Survival Rate
Lymph Nodes
Monoclonal Antibodies
Regression Analysis
Staining and Labeling
Mutation
Survival

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Maehara, Y., Tomoda, M., Hasuda, S., Kabashima, A., Tokunaga, E., Kakeji, Y., & Sugimachi, K. (1999). Prognostic value of p53 protein expression for patients with gastric cancer: A multivariate analysis. British journal of cancer, 79(7-8), 1255-1261. https://doi.org/10.1038/sj.bjc.6690201

Prognostic value of p53 protein expression for patients with gastric cancer : A multivariate analysis. / Maehara, Yoshihiko; Tomoda, M.; Hasuda, S.; Kabashima, Akira; Tokunaga, E.; Kakeji, Y.; Sugimachi, K.

In: British journal of cancer, Vol. 79, No. 7-8, 28.02.1999, p. 1255-1261.

Research output: Contribution to journalArticle

Maehara, Y, Tomoda, M, Hasuda, S, Kabashima, A, Tokunaga, E, Kakeji, Y & Sugimachi, K 1999, 'Prognostic value of p53 protein expression for patients with gastric cancer: A multivariate analysis', British journal of cancer, vol. 79, no. 7-8, pp. 1255-1261. https://doi.org/10.1038/sj.bjc.6690201
Maehara, Yoshihiko ; Tomoda, M. ; Hasuda, S. ; Kabashima, Akira ; Tokunaga, E. ; Kakeji, Y. ; Sugimachi, K. / Prognostic value of p53 protein expression for patients with gastric cancer : A multivariate analysis. In: British journal of cancer. 1999 ; Vol. 79, No. 7-8. pp. 1255-1261.
@article{fd553de6ec05464facd165112dbd8851,
title = "Prognostic value of p53 protein expression for patients with gastric cancer: A multivariate analysis",
abstract = "Mutations in the p53 gene, one of the most common genetic alterations in human cancer, are implicated in tumorigenesis and tumour progression. Although p53 protein expression appears to be correlated to prognosis in patients with malignancy, its prognostic role in gastric cancer has remained controversial. We examined the clinical significance of p53 overexpression in 427 patients with gastric cancer, using multivariate analysis. Tumour sections of gastric cancer tissues from these 427 Japanese patients were stained immunohistochemically with monoclonal antibody PAb1801. The presence of p53 expression was statistically compared with clinicopathological features and postoperative survival, using univariate and muitivariate analyses. p53 expression was detected in 38.6{\%} (165 out of 427) of these gastric cancers and immunoreactivity was not observed in normal mucosa adjacent to the tumour. A higher rate of p53 detection was observed among large tumours and in those with a prominent depth of invasion, lymphatic and vascular invasion and lymph node involvement. Prognosis was significantly worse for patients with p53-positive-staining tumours. The 5-year survival rate was 62.5{\%} for patients with p53-negative tumours and 43.3{\%} for those with positive malignancies. p53 expression was a significant prognostic factor for node-positive gastric cancers in subjects undergoing treatment with curative resection, as assessed by Cox regression analysis. Thus, the expression of p53 was closely related to the potential for tumour advance and a poorer post-operative prognosis for patients with gastric cancer.",
author = "Yoshihiko Maehara and M. Tomoda and S. Hasuda and Akira Kabashima and E. Tokunaga and Y. Kakeji and K. Sugimachi",
year = "1999",
month = "2",
day = "28",
doi = "10.1038/sj.bjc.6690201",
language = "English",
volume = "79",
pages = "1255--1261",
journal = "British Journal of Cancer",
issn = "0007-0920",
publisher = "Nature Publishing Group",
number = "7-8",

}

TY - JOUR

T1 - Prognostic value of p53 protein expression for patients with gastric cancer

T2 - A multivariate analysis

AU - Maehara, Yoshihiko

AU - Tomoda, M.

AU - Hasuda, S.

AU - Kabashima, Akira

AU - Tokunaga, E.

AU - Kakeji, Y.

AU - Sugimachi, K.

PY - 1999/2/28

Y1 - 1999/2/28

N2 - Mutations in the p53 gene, one of the most common genetic alterations in human cancer, are implicated in tumorigenesis and tumour progression. Although p53 protein expression appears to be correlated to prognosis in patients with malignancy, its prognostic role in gastric cancer has remained controversial. We examined the clinical significance of p53 overexpression in 427 patients with gastric cancer, using multivariate analysis. Tumour sections of gastric cancer tissues from these 427 Japanese patients were stained immunohistochemically with monoclonal antibody PAb1801. The presence of p53 expression was statistically compared with clinicopathological features and postoperative survival, using univariate and muitivariate analyses. p53 expression was detected in 38.6% (165 out of 427) of these gastric cancers and immunoreactivity was not observed in normal mucosa adjacent to the tumour. A higher rate of p53 detection was observed among large tumours and in those with a prominent depth of invasion, lymphatic and vascular invasion and lymph node involvement. Prognosis was significantly worse for patients with p53-positive-staining tumours. The 5-year survival rate was 62.5% for patients with p53-negative tumours and 43.3% for those with positive malignancies. p53 expression was a significant prognostic factor for node-positive gastric cancers in subjects undergoing treatment with curative resection, as assessed by Cox regression analysis. Thus, the expression of p53 was closely related to the potential for tumour advance and a poorer post-operative prognosis for patients with gastric cancer.

AB - Mutations in the p53 gene, one of the most common genetic alterations in human cancer, are implicated in tumorigenesis and tumour progression. Although p53 protein expression appears to be correlated to prognosis in patients with malignancy, its prognostic role in gastric cancer has remained controversial. We examined the clinical significance of p53 overexpression in 427 patients with gastric cancer, using multivariate analysis. Tumour sections of gastric cancer tissues from these 427 Japanese patients were stained immunohistochemically with monoclonal antibody PAb1801. The presence of p53 expression was statistically compared with clinicopathological features and postoperative survival, using univariate and muitivariate analyses. p53 expression was detected in 38.6% (165 out of 427) of these gastric cancers and immunoreactivity was not observed in normal mucosa adjacent to the tumour. A higher rate of p53 detection was observed among large tumours and in those with a prominent depth of invasion, lymphatic and vascular invasion and lymph node involvement. Prognosis was significantly worse for patients with p53-positive-staining tumours. The 5-year survival rate was 62.5% for patients with p53-negative tumours and 43.3% for those with positive malignancies. p53 expression was a significant prognostic factor for node-positive gastric cancers in subjects undergoing treatment with curative resection, as assessed by Cox regression analysis. Thus, the expression of p53 was closely related to the potential for tumour advance and a poorer post-operative prognosis for patients with gastric cancer.

UR - http://www.scopus.com/inward/record.url?scp=0032983645&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032983645&partnerID=8YFLogxK

U2 - 10.1038/sj.bjc.6690201

DO - 10.1038/sj.bjc.6690201

M3 - Article

C2 - 10098768

AN - SCOPUS:0032983645

VL - 79

SP - 1255

EP - 1261

JO - British Journal of Cancer

JF - British Journal of Cancer

SN - 0007-0920

IS - 7-8

ER -