Prognostic value of the histological subtype in completely resected non-small cell lung cancer

Tatsuro Okamoto, Riichiroh Maruyama, Ryuichi Suemitsu, Yoshiro Aoki, Hiroshi Wataya, Miyako Kojo, Yukito Ichinose

Research output: Contribution to journalArticle

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Abstract

Non-small cell lung cancer (NSCLC), which includes several different histological subtypes, is usually treated by the same strategy. However, the biological behavior of each cell type appears to be different. We retrospectively reviewed the clinical records of 1119 consecutive NSCLC patients who underwent a complete resection, in order to investigate whether a histological cell type is a powerful prognostic factor. The overall 5- and 10-year survivals of the patients with adenocarcinoma (AD), squamous cell carcinoma (SQ), large cell carcinoma (LA), and adenosquamous cell carcinoma (AS) were 54.2 and 40.2%, 51.6 and 30.3%, 40.9 and 18.7%, and 35.1 and 30.1%, respectively. The AD patients had a significantly better survival than the non-AD patients in Stage I (P = 0.0004), whereas the SQ patients had a better survival than the non-SQ patients in Stage II (P = 0.018). A multivariate survival analysis indicated the AD patients to have a significantly better survival than the SQ patients in Stage IA (P = 0.04), while the SQ patients had a better survival than the AD patients in Stage II (P = 0.03). These above observations suggest that the prognosis after complete resection is different between adenocarcinoma and squamous cell carcinoma in Stage IA and II.

Original languageEnglish
Pages (from-to)362-366
Number of pages5
JournalInteractive cardiovascular and thoracic surgery
Volume5
Issue number4
DOIs
Publication statusPublished - Aug 1 2006

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Non-Small Cell Lung Carcinoma
Adenocarcinoma
Survival
Squamous Cell Carcinoma
Adenosquamous Carcinoma
Large Cell Carcinoma
Survival Analysis
Multivariate Analysis

All Science Journal Classification (ASJC) codes

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine

Cite this

Prognostic value of the histological subtype in completely resected non-small cell lung cancer. / Okamoto, Tatsuro; Maruyama, Riichiroh; Suemitsu, Ryuichi; Aoki, Yoshiro; Wataya, Hiroshi; Kojo, Miyako; Ichinose, Yukito.

In: Interactive cardiovascular and thoracic surgery, Vol. 5, No. 4, 01.08.2006, p. 362-366.

Research output: Contribution to journalArticle

Okamoto, Tatsuro ; Maruyama, Riichiroh ; Suemitsu, Ryuichi ; Aoki, Yoshiro ; Wataya, Hiroshi ; Kojo, Miyako ; Ichinose, Yukito. / Prognostic value of the histological subtype in completely resected non-small cell lung cancer. In: Interactive cardiovascular and thoracic surgery. 2006 ; Vol. 5, No. 4. pp. 362-366.
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