Progress report on the Hypertension Objective Treatment Based on Measurement by Electrical Devices of Blood Pressure (HOMED-BP) study: Status at February 2004

Keiko Hosohata, Shin Saito, Kei Asayama, Takayoshi Ohkubo, Masahiro Kikuya, Hirohito Metoki, Taku Obara, Tetsuo Kato, Junichiro Hashimoto, Kazuhito Totsune, Yukio Miura, Yutaka Imai, Kikuo Arakawa, Masatoshi Fujishima, Jun Fujii, Koushiro Fukiyama, Shigeru Hisamichi, Osamu Iimura, Masao Ishii, Teruo OmaeTakao Saruta, Kaoru Yoshinaga, Isao Abe, Kouji Abe, Teruo Abukawa, Terunao Ashida, Nobutaka Dohba, Tanenao Etoh, Akio Fujimura, Toshiro Fujita, Akio Fukui, Toshikazu Gotoh, Hitoshi Hama, Takuzo Hano, Hiroshi Hayashi, Noriaki Hayashida, Masato Hayashi, Katsuhiko Hiramori, Yasunobu Hirai, Yukio Hirata, Kunio Hiwada, Kazuhito Hora, Shuichi Ichikawa, Toshiho Iida, Toshio Ikeda, Tsutomu Imaizumi, Kinji Ishikawa, Ichisuke Ito, Masaaki Ito, Sadayoshi Ito, Daisuke Iwaoka, Ken Kanamasa, Takashi Katagiri, Shigehiro Katayama, Hiroshi Kawamura, Yuhei Kawano, Hiroshi Kida, Kenjiro Kikuchi, Genjiro Kimura, Kenjiro Kimura, Hiroshi Kitaoka, Shoutai Kobayashi, Katsuhiko Kohara, Shunichi Kojima, Issei Komuro, Hiroo Kumagai, Yuji Kumagai, Eiji Kusano, Toshio Kushiro, Iwao Kuwajima, Yukio Maruyama, Fumiaki Masani, Hiroaki Matsubara, Tatsuaki Matsubara, Masayasu Matsumoto, Hiroaki Matsuoka, Hideo Matsuura, Yasuo Mishima, Mamoru Miura, Isamu Miyamori, Hideki Mori, Hidenori Murakami, Hiromi Muratani, Motoya Nakagawa, Kazuwa Nakao, Mitsuhide Naruse, Ichiro Nishio, Toshio Ogihara, Masahiro Ohta, Kuniaki Ohtsuka, Youichi Ohtsuka, Yasuyoshi Ohuchi, Shinichi Oikawa, Masaaki Okabe, Ken Okumura, Ikuo Saitoh, Hisao Saitoh, Toshiie Sakata, Keijiro Saku, Hidetada Sasaki, Masahide Seino, Shouichi Senda, Kazuyuki Shimada, Kazuaki Shimamoto, Mitsuyuki Shimizu, Toshiaki Shiomi, Kunio Shirato, Masayoshi Sone, Hiromichi Suzuki, Shin Suzuki, Hakuo Takahashi, Masanobu Takada, Kazuo Takeda, Noriyuki Takeda, Akira Takeshita, Shuichi Takishita, Shigemichi Tanaka, Kenji Toba, Osamu Tochikubo, Hitonobu Tomoike, Yuji Ueno, Satoshi Umemura, Hidenori Urata, Takeshi Watanabe, Kenichi Yamada, Tohru Yamaguchi, Minoru Yamakado, Yasumasa Yamamoto, Yoshiharu Yamamoto, Akira Yamashina, Hitoshi Yokoyama, Manabu Yoshimura, Hiroshi Satoh, Yoshitomo Oka, Hideki Katagiri, Yoshiaki Kondo, Hisayasu Shishido, Akiko Kohinata, Yohko Kanno, Hiroko Ikeda, Yuri Takahira, Takahito Takahashi, Atsushi Kimura, Jin Funahashi, Noriko Takada, Tomohiro Hanazawa, Naoko Suzuki, Motoko Osugi, Juinichiro Hashimoto, Y. Ogawa, T. Miyamura, Y. Masuda, S. Tanaka, S. Tanaka, M. Koizumi, T. Ando, T. Endo, A. Tsuchida, M. Nanba, S. Yonekura, M. Shiroishi, M. Nakagawa, K. Ito, K. Oda, K. Takahashi, I. Kanahara, N. Hirota, M. Tsutsui, J. Anzai, S. Hosoda, M. Shiiki, Y. Takagawa, M. Iida, M. Tada, T. Noto, H. Tanaka, G. Tajima, K. Kawamorita, K. Kikuchi, H. Suzuki, K. Suzuki, K. Komai, H. Seki, A. Omoto, H. Takahashi, A. Kitabayashi, M. Kimura, Y. Kimura, H. Yamamoto, K. Takahashi, H. Kimura, Y. Kawamorita, Y. Emura, Y. Suzuki, Y. Ishikawa, K. Nagai, S. Nagai, T. Ito, K. Nihei, S. Yamada, T. Goto, N. Yamamoto, Y. Suzuki, H. Ito, M. Ito, T. Fujita, Y. Tominaga, S. Tominaga, K. Suzuki, K. Ishibashi, Y. Ando, S. Sato, H. Morikawa, S. Kashima, D. Nakayama, Y. Hayashi, K. Ohta, H. Metoki, K. Fukami, T. Hayashi, M. Kishi, J. Tajima, J. Seino, H. Hoshi, Y. Imai, H. Kimura, R. Mori, K. Matsuo, Y. Tanno, A. Shibasaki, T. Yamagishi, E. Ohtomo, Y. Ohtsuka, S. Sasaki, M. Seino, K. Kurosawa, K. Ito, Y. Takagi, S. Kyogoku, K. Ito, Y. Ono, M. Watanabe, S. Watanabe, N. Hiwatashi, C. Yagi, H. Unakami, K. Asayama, T. Mouri, T. Watanabe, K. Kikuchi, N. Maruyama, M. Sone, M. Iwamoto, S. Naganuma, H. Mashiko, H. Ishii, Y. Takaya, M. Kamimoto, A. Shirai, R. Watanabe, Y. Tohyama, F. Araki, H. Sakuma, Y. Amada, E. Sato, M. Techigawara, K. Nakamura, T. Nakayama, K. Hasegawa, K. Hasegawa, T. Nagao, J. Minami, Y. Kumagai, T. Cho, K. Okamoto, T. Iguchi, T. Honzawa, T. Koitabashi, T. Yamada, H. Horikoshi, T. Nagao, H. Yoshimatsu, K. Seki, N. Akiyama, H. Suga, R. Matsunaga, T. Sinozaki, Y. Ishimaru, N. Yagi, H. Takikawa, T. Hukutome, C. Nakajima, H. Sato, J. Simizu, M. Arai, H. Koide, H. Takada, T. Sato, T. Umezu, H. Aoki, H. Nakamoto, K. Komahashi, S. Sekiya, H. Sugimoto, T. Arai, H. Suzuki, S. Inokuma, T. Funazaki, F. Yasuda, S. Kanouzawa, C. Yokota, Y. Noguchi, M. Hatano, T. Izumida, T. Hara, H. Muranaka, M. Suzuki, Y. Ogawa, E. Yabumoto, S. Matsushita, K. Kohzu, F. Sasaki, N. Hata, M. Yanagisawa, T. Ueda, M. Kurosawa, S. Doutare, S. Higashi, M. Kato, T. Hoshino, K. Fukuda, K. Ohtsuki, T. Ikeda, T. Kasatani, T. Yamada, S. Yatagai, E. Ohsuga, M. Yamakado, H. Kawamura, H. Mitsubayashi, S. Yamashina, J. Yamazaki, S. Nanjo, S. Ito, T. Teramoto, T. Gomi, S. Kato, N. Koekawa, K. Kuwaki, T. Ikeda, K. Hori, S. Arai, H. Koyama, M. Ichikawa, A. Hashimoto, H. Mori, S. Abe, Y. Ohba, F. Kurata, M. Miyakawa, K. Kimura, Y. Hatori, M. Ushiyama, H. Yamamoto, M. Adachi, K. Takayama, M. Shimizu, T. Iida, S. Asato, K. Uchiba, N. Watanabe, M. Kotani, F. Akaoka, S. Takahashi, K. Hirahara, S. Suzuki, Y. Yamaguchi, S. Ishikawa, K. Sasaki, Y. Terada, S. Ohhashi, A. Sakamaki, N. Hifumi, T. Ohno, T. Saeki, Y. Suzaki, H. Yamamoto, T. Nakagawa, F. Tomoda, H. Nishino, T. Ise, H. Takakuwa, H. Yokoyama, S. Kitakawa, K. Takasawa, T. Ohkura, Y. Yamamoto, K. Satake, Y. Arai, H. Nakayama, S. Sugiyama, K. Sugiura, M. Yokoyama, A. Ito, K. Okazaki, R. Saito, J. Mihara, A. Naito, Y. Takahira, T. Mori, M. Watanabe, S. Asai, O. Nojiri, K. Sakakura, M. Kozuka, Y. Oyama, Y. Kawamura, T. Inoko, N. Takeuchi, H. Tatematsu, Y. Hayakawa, N. Adachi, N. Tamagaki, T. Nakamura, A. Fukui, M. Amenomori, T. Kanaya, A. Masui, K. Hayashi, S. Nishi, M. Amari, K. Yoshida, Y. Matsushita, S. Sawada, M. Fujiwara, S. Ono, K. Tamai, Y. Takemoto, T. Kanemasa, T. Takenaka, K. Kitayama, K. Yasui, S. Fujita, Y. Terayama, N. Kato, M. Nagai, H. Takashima, K. Watanabe, N. Hirobe, M. Miyamoto, N. Sakamoto, Y. Kurimoto, N. Suzuki, S. Katsuya, T. Katsuya, K. Nagao, K. Nakamuta, S. Goto, T. Ueda, N. Imai, I. Sano, H. Ueda, N. Takahashi, T. Sada, M. Iwane, H. Suzuki, H. Yoshikawa, Y. Tominaga, M. Kamura, A. Ohtahara, Y. Nakamura, M. Osakada, M. Gen, M. Kahara, T. Yoshimoto, K. Mizuno, Y. Furukawa, A. Tokunaga, N. Sasaki, M. Matsumura, T. Furue, K. Iwasaki, K. Ichiki, S. Mizofuchi, T. Yokoi, W. Furumoto, T. Fukui, K. Fujino, A. Ohta, S. Ueda, Y. Kitami, T. Ohkura, M. Takeuchi, K. Yoshida, S. Nishiyama, R. Kawamoto, A. Kobaru, T. Endo, K. Kitano, Y. Hirooka, M. Tohaya, Y. Miyazaki, K. Onoyama, J. Miyagi, U. Kin, Y. Fujishima, A. Kuwahara, R. Shindo, Y. Satake, T. Moritsuka, T. Kuwahara, O. Hano, Y. Takagi, S. Suzuki, K. Abe, T. Sato, M. Kohno, T. Fujino, K. Wakayama, T. Aso, T. Goto, H. Ozaki, K. Ninomiya, Y. Inobe, S. Hamasaki, J. Inoue, S. Naomi, T. Iwaoka, T. Ono, Y. Muta, Y. Endo, H. Ohmori, M. Nagata, N. Wake, H. Kozawa, Y. Tomino, T. Ikeda, H. Yoshii, H. Nakamura, N. Fujimoto, T. Asato, M. Tozawa, R. Sunagawa, Y. Nakamura, H. Tomori, K. Takashiba

Research output: Contribution to journalArticle

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Abstract

The Hypertension Objective Treatment Based on Measurement by Electrical Devices of Blood Pressure (HOMED-BP) Study is the first large-scale intervention trial in Japan using a PROBE design to determine an optimal target blood pressure (BP) level on the basis of self-measured BP at home and optimal initial antihypertensive medication. The registered patients are randomized to one of two different BP levels and to initial antihypertensive regimens (i.e., calcium antagonist [Ca-A], angiotensin-converting enzyme inhibitor [ACE-I], or angiotensin II receptor antagonist [ARB]).At the end of February 2004, 2729, 1687, and 971 patients were recruited, randomized, and followed-up for 12 months or more. Among the 971 patients, mean systolic/diastolic BP levels at randomization in the Ca-A, ACE-I, and ARB groups were 150/90, 152/89, and 151/89 mmHg, respectively. These values reduced after six months of Ca-A-, ACE-I-, and ARB-based treatment (133/81 mmHg, 135/80 mmHg, and 134/79 mmHg, respectively) and further reduced after 12 months (131/80 mmHg, 134/79 mmHg, and 132/79 mmHg, respectively) without any significant differences among groups. In more intensive and less intensive BP-lowering groups, mean systolic/diastolic BP levels at randomization were 151/90 and 150/89 mmHg, respectively. Although BP levels reduced after 6-month (135/80 mmHg and 133/80 mmHg, respectively) and 12-month treatment (133/79 mmHg and 132/80 mmHg, respectively) in each target group, no significant difference in BP values was observed between groups. These results indicate the necessity of additional interventional strategies to improve the achievement of target BP levels, especially in the more intensive BP-lowering group.

Original languageEnglish
Pages (from-to)69-81
Number of pages13
JournalClinical and Experimental Hypertension
Volume29
Issue number1
DOIs
Publication statusPublished - Jan 1 2007

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All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Physiology

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