Progressive reduction of auditory evoked gamma in first episode schizophrenia but not clinical high risk individuals

Naoya Oribe, Yoji Hirano, Elisabetta del Re, Larry J. Seidman, Raquelle I. Mesholam-Gately, Kristen A. Woodberry, Joanne D. Wojcik, Takefumi Ueno, Shigenobu Kanba, Toshiaki Onitsuka, Martha E. Shenton, Jill M. Goldstein, Margaret A. Niznikiewicz, Robert W. McCarley, Kevin M. Spencer

Research output: Contribution to journalArticle

Abstract

The early auditory-evoked gamma band response (EAGBR) may serve as an index of the integrity of fast recurrent inhibition or synaptic connectivity in the auditory cortex, where abnormalities in individuals with schizophrenia have been consistently found. The EAGBR has been rarely investigated in first episode schizophrenia patients (FESZ) and individuals at clinical high risk (CHR) for schizophrenia, and never been compared directly between these populations nor evaluated longitudinally. Here we examined the EAGBR in FESZ, CHR, and matched healthy controls (HC) at baseline and 1-year follow-up assessments to determine whether the EAGBR was affected in these clinical groups, and whether any EAGBR abnormalities changed over time. The electroencephalogram was recorded with a dense electrode array while subjects (18 FESZ, 18 CHR, and 40 HC) performed an auditory oddball task. Event-related spectral measures (phase locking factor [PLF] and evoked power) were computed on Morlet-wavelet-transformed single epochs from the standard trials. At baseline, EAGBR PLF and evoked power did not differ between groups. FESZ showed progressive reductions of PLF and evoked power from baseline to follow-up, and deficits in PLF at follow-up compared to HC. EAGBR peak frequency also increased at temporal sites in FESZ from baseline to follow-up. Longitudinal effects on the EAGBR were not found in CHR or HC, nor did these groups differ at follow-up. In conclusion, we detected neurophysiological changes of auditory cortex function in FESZ during a one-year period, which were not observed in CHR. These findings are discussed within the context of neurodevelopmental models of schizophrenia.

Original languageEnglish
Pages (from-to)145-152
Number of pages8
JournalSchizophrenia research
Volume208
DOIs
Publication statusPublished - Jun 2019

Fingerprint

Schizophrenia
Auditory Cortex
Electroencephalography
Electrodes
Control Groups
Population
Power (Psychology)

All Science Journal Classification (ASJC) codes

  • Psychiatry and Mental health
  • Biological Psychiatry

Cite this

Progressive reduction of auditory evoked gamma in first episode schizophrenia but not clinical high risk individuals. / Oribe, Naoya; Hirano, Yoji; del Re, Elisabetta; Seidman, Larry J.; Mesholam-Gately, Raquelle I.; Woodberry, Kristen A.; Wojcik, Joanne D.; Ueno, Takefumi; Kanba, Shigenobu; Onitsuka, Toshiaki; Shenton, Martha E.; Goldstein, Jill M.; Niznikiewicz, Margaret A.; McCarley, Robert W.; Spencer, Kevin M.

In: Schizophrenia research, Vol. 208, 06.2019, p. 145-152.

Research output: Contribution to journalArticle

Oribe, N, Hirano, Y, del Re, E, Seidman, LJ, Mesholam-Gately, RI, Woodberry, KA, Wojcik, JD, Ueno, T, Kanba, S, Onitsuka, T, Shenton, ME, Goldstein, JM, Niznikiewicz, MA, McCarley, RW & Spencer, KM 2019, 'Progressive reduction of auditory evoked gamma in first episode schizophrenia but not clinical high risk individuals', Schizophrenia research, vol. 208, pp. 145-152. https://doi.org/10.1016/j.schres.2019.03.025
Oribe, Naoya ; Hirano, Yoji ; del Re, Elisabetta ; Seidman, Larry J. ; Mesholam-Gately, Raquelle I. ; Woodberry, Kristen A. ; Wojcik, Joanne D. ; Ueno, Takefumi ; Kanba, Shigenobu ; Onitsuka, Toshiaki ; Shenton, Martha E. ; Goldstein, Jill M. ; Niznikiewicz, Margaret A. ; McCarley, Robert W. ; Spencer, Kevin M. / Progressive reduction of auditory evoked gamma in first episode schizophrenia but not clinical high risk individuals. In: Schizophrenia research. 2019 ; Vol. 208. pp. 145-152.
@article{ea26e6c645584b50bc82620ea31ae68b,
title = "Progressive reduction of auditory evoked gamma in first episode schizophrenia but not clinical high risk individuals",
abstract = "The early auditory-evoked gamma band response (EAGBR) may serve as an index of the integrity of fast recurrent inhibition or synaptic connectivity in the auditory cortex, where abnormalities in individuals with schizophrenia have been consistently found. The EAGBR has been rarely investigated in first episode schizophrenia patients (FESZ) and individuals at clinical high risk (CHR) for schizophrenia, and never been compared directly between these populations nor evaluated longitudinally. Here we examined the EAGBR in FESZ, CHR, and matched healthy controls (HC) at baseline and 1-year follow-up assessments to determine whether the EAGBR was affected in these clinical groups, and whether any EAGBR abnormalities changed over time. The electroencephalogram was recorded with a dense electrode array while subjects (18 FESZ, 18 CHR, and 40 HC) performed an auditory oddball task. Event-related spectral measures (phase locking factor [PLF] and evoked power) were computed on Morlet-wavelet-transformed single epochs from the standard trials. At baseline, EAGBR PLF and evoked power did not differ between groups. FESZ showed progressive reductions of PLF and evoked power from baseline to follow-up, and deficits in PLF at follow-up compared to HC. EAGBR peak frequency also increased at temporal sites in FESZ from baseline to follow-up. Longitudinal effects on the EAGBR were not found in CHR or HC, nor did these groups differ at follow-up. In conclusion, we detected neurophysiological changes of auditory cortex function in FESZ during a one-year period, which were not observed in CHR. These findings are discussed within the context of neurodevelopmental models of schizophrenia.",
author = "Naoya Oribe and Yoji Hirano and {del Re}, Elisabetta and Seidman, {Larry J.} and Mesholam-Gately, {Raquelle I.} and Woodberry, {Kristen A.} and Wojcik, {Joanne D.} and Takefumi Ueno and Shigenobu Kanba and Toshiaki Onitsuka and Shenton, {Martha E.} and Goldstein, {Jill M.} and Niznikiewicz, {Margaret A.} and McCarley, {Robert W.} and Spencer, {Kevin M.}",
year = "2019",
month = "6",
doi = "10.1016/j.schres.2019.03.025",
language = "English",
volume = "208",
pages = "145--152",
journal = "Schizophrenia Research",
issn = "0920-9964",
publisher = "Elsevier",

}

TY - JOUR

T1 - Progressive reduction of auditory evoked gamma in first episode schizophrenia but not clinical high risk individuals

AU - Oribe, Naoya

AU - Hirano, Yoji

AU - del Re, Elisabetta

AU - Seidman, Larry J.

AU - Mesholam-Gately, Raquelle I.

AU - Woodberry, Kristen A.

AU - Wojcik, Joanne D.

AU - Ueno, Takefumi

AU - Kanba, Shigenobu

AU - Onitsuka, Toshiaki

AU - Shenton, Martha E.

AU - Goldstein, Jill M.

AU - Niznikiewicz, Margaret A.

AU - McCarley, Robert W.

AU - Spencer, Kevin M.

PY - 2019/6

Y1 - 2019/6

N2 - The early auditory-evoked gamma band response (EAGBR) may serve as an index of the integrity of fast recurrent inhibition or synaptic connectivity in the auditory cortex, where abnormalities in individuals with schizophrenia have been consistently found. The EAGBR has been rarely investigated in first episode schizophrenia patients (FESZ) and individuals at clinical high risk (CHR) for schizophrenia, and never been compared directly between these populations nor evaluated longitudinally. Here we examined the EAGBR in FESZ, CHR, and matched healthy controls (HC) at baseline and 1-year follow-up assessments to determine whether the EAGBR was affected in these clinical groups, and whether any EAGBR abnormalities changed over time. The electroencephalogram was recorded with a dense electrode array while subjects (18 FESZ, 18 CHR, and 40 HC) performed an auditory oddball task. Event-related spectral measures (phase locking factor [PLF] and evoked power) were computed on Morlet-wavelet-transformed single epochs from the standard trials. At baseline, EAGBR PLF and evoked power did not differ between groups. FESZ showed progressive reductions of PLF and evoked power from baseline to follow-up, and deficits in PLF at follow-up compared to HC. EAGBR peak frequency also increased at temporal sites in FESZ from baseline to follow-up. Longitudinal effects on the EAGBR were not found in CHR or HC, nor did these groups differ at follow-up. In conclusion, we detected neurophysiological changes of auditory cortex function in FESZ during a one-year period, which were not observed in CHR. These findings are discussed within the context of neurodevelopmental models of schizophrenia.

AB - The early auditory-evoked gamma band response (EAGBR) may serve as an index of the integrity of fast recurrent inhibition or synaptic connectivity in the auditory cortex, where abnormalities in individuals with schizophrenia have been consistently found. The EAGBR has been rarely investigated in first episode schizophrenia patients (FESZ) and individuals at clinical high risk (CHR) for schizophrenia, and never been compared directly between these populations nor evaluated longitudinally. Here we examined the EAGBR in FESZ, CHR, and matched healthy controls (HC) at baseline and 1-year follow-up assessments to determine whether the EAGBR was affected in these clinical groups, and whether any EAGBR abnormalities changed over time. The electroencephalogram was recorded with a dense electrode array while subjects (18 FESZ, 18 CHR, and 40 HC) performed an auditory oddball task. Event-related spectral measures (phase locking factor [PLF] and evoked power) were computed on Morlet-wavelet-transformed single epochs from the standard trials. At baseline, EAGBR PLF and evoked power did not differ between groups. FESZ showed progressive reductions of PLF and evoked power from baseline to follow-up, and deficits in PLF at follow-up compared to HC. EAGBR peak frequency also increased at temporal sites in FESZ from baseline to follow-up. Longitudinal effects on the EAGBR were not found in CHR or HC, nor did these groups differ at follow-up. In conclusion, we detected neurophysiological changes of auditory cortex function in FESZ during a one-year period, which were not observed in CHR. These findings are discussed within the context of neurodevelopmental models of schizophrenia.

UR - http://www.scopus.com/inward/record.url?scp=85064314995&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85064314995&partnerID=8YFLogxK

U2 - 10.1016/j.schres.2019.03.025

DO - 10.1016/j.schres.2019.03.025

M3 - Article

C2 - 31005464

AN - SCOPUS:85064314995

VL - 208

SP - 145

EP - 152

JO - Schizophrenia Research

JF - Schizophrenia Research

SN - 0920-9964

ER -