Proliferative activity as a prognostic factor in Borrmann type 4 gastric carcinoma

Y. Kakeji; Y. Maehara; Y. Adachi; H. Baba; M. Mori; M. Furusawa; K. Sugimachi

doi:10.1038/bjc.1994.141

Proliferative activity as a prognostic factor in Borrmann type 4 gastric carcinoma

Y. Kakeji, Y. Maehara, Y. Adachi, H. Baba, M. Mori, M. Furusawa, K. Sugimachi

Surgery

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Abstract

Proliferative activities in 181 primary Borrmann type 4 gastric carcinomas were investigated using percentage labelling of proliferating cell nuclear antigen (PCNA) and an argyrophilic nucleolar organiser region (AgNOR) count. Tumours with a high proliferative activity often metastasised to lymph nodes (P < 0.01), and these patients had a lower survival rate (P < 0.05). A significant correlation was recognised between the PCNA labelling percentage and AgNOR count (r = 0.452, P < 0.001). Cox's regression analysis showed that PCNA labelling percentage is an independent prognostic factor. These results indicate that estimating proliferative activity may be useful in predicting lymph node metastasis and patients’ prognosis in cases of Borrmann type 4 gastric carcinoma.

Original language	English
Pages (from-to)	749-753
Number of pages	5
Journal	British journal of cancer
Volume	69
Issue number	4
DOIs	https://doi.org/10.1038/bjc.1994.141
Publication status	Published - Apr 1994

All Science Journal Classification (ASJC) codes

Oncology
Cancer Research

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10.1038/bjc.1994.141

Cite this

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abstract = "Proliferative activities in 181 primary Borrmann type 4 gastric carcinomas were investigated using percentage labelling of proliferating cell nuclear antigen (PCNA) and an argyrophilic nucleolar organiser region (AgNOR) count. Tumours with a high proliferative activity often metastasised to lymph nodes (P < 0.01), and these patients had a lower survival rate (P < 0.05). A significant correlation was recognised between the PCNA labelling percentage and AgNOR count (r = 0.452, P < 0.001). Cox's regression analysis showed that PCNA labelling percentage is an independent prognostic factor. These results indicate that estimating proliferative activity may be useful in predicting lymph node metastasis and patients{\textquoteright} prognosis in cases of Borrmann type 4 gastric carcinoma.",

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AU - Kakeji, Y.

AU - Maehara, Y.

AU - Adachi, Y.

AU - Baba, H.

AU - Mori, M.

AU - Furusawa, M.

AU - Sugimachi, K.

PY - 1994/4

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AB - Proliferative activities in 181 primary Borrmann type 4 gastric carcinomas were investigated using percentage labelling of proliferating cell nuclear antigen (PCNA) and an argyrophilic nucleolar organiser region (AgNOR) count. Tumours with a high proliferative activity often metastasised to lymph nodes (P < 0.01), and these patients had a lower survival rate (P < 0.05). A significant correlation was recognised between the PCNA labelling percentage and AgNOR count (r = 0.452, P < 0.001). Cox's regression analysis showed that PCNA labelling percentage is an independent prognostic factor. These results indicate that estimating proliferative activity may be useful in predicting lymph node metastasis and patients’ prognosis in cases of Borrmann type 4 gastric carcinoma.

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Proliferative activity as a prognostic factor in Borrmann type 4 gastric carcinoma

Abstract

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