Proliferative activity as a prognostic factor in Borrmann type 4 gastric carcinoma

Y. Kakeji, Yoshihiko Maehara, Y. Adachi, H. Baba, Masaki Mori, M. Furusawa, K. Sugimachi

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Proliferative activities in 181 primary Borrmann type 4 gastric carcinomas were investigated using percentage labelling of proliferating cell nuclear antigen (PCNA) and an argyrophilic nucleolar organiser region (AgNOR) count. Tumours with a high proliferative activity often metastasised to lymph nodes (P < 0.01), and these patients had a lower survival rate (P < 0.05). A significant correlation was recognised between the PCNA labelling percentage and AgNOR count (r = 0.452, P < 0.001). Cox's regression analysis showed that PCNA labelling percentage is an independent prognostic factor. These results indicate that estimating proliferative activity may be useful in predicting lymph node metastasis and patients’ prognosis in cases of Borrmann type 4 gastric carcinoma.

Original languageEnglish
Pages (from-to)749-753
Number of pages5
JournalBritish journal of cancer
Volume69
Issue number4
DOIs
Publication statusPublished - Jan 1 1994

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Proliferating Cell Nuclear Antigen
Nucleolus Organizer Region
Stomach
Carcinoma
Lymph Nodes
Survival Rate
Regression Analysis
Neoplasm Metastasis
Neoplasms

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Kakeji, Y., Maehara, Y., Adachi, Y., Baba, H., Mori, M., Furusawa, M., & Sugimachi, K. (1994). Proliferative activity as a prognostic factor in Borrmann type 4 gastric carcinoma. British journal of cancer, 69(4), 749-753. https://doi.org/10.1038/bjc.1994.141

Proliferative activity as a prognostic factor in Borrmann type 4 gastric carcinoma. / Kakeji, Y.; Maehara, Yoshihiko; Adachi, Y.; Baba, H.; Mori, Masaki; Furusawa, M.; Sugimachi, K.

In: British journal of cancer, Vol. 69, No. 4, 01.01.1994, p. 749-753.

Research output: Contribution to journalArticle

Kakeji, Y, Maehara, Y, Adachi, Y, Baba, H, Mori, M, Furusawa, M & Sugimachi, K 1994, 'Proliferative activity as a prognostic factor in Borrmann type 4 gastric carcinoma', British journal of cancer, vol. 69, no. 4, pp. 749-753. https://doi.org/10.1038/bjc.1994.141
Kakeji, Y. ; Maehara, Yoshihiko ; Adachi, Y. ; Baba, H. ; Mori, Masaki ; Furusawa, M. ; Sugimachi, K. / Proliferative activity as a prognostic factor in Borrmann type 4 gastric carcinoma. In: British journal of cancer. 1994 ; Vol. 69, No. 4. pp. 749-753.
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