Prolonged resolution of hemophagocytic lymphohistiocytosis following myeloablative chemotherapy and subsequent autologous peripheral blood stem cell transplantation

Shoichi Ohga, A. Nomura, T. Kai, A. Matsuzaki, S. Inaba, M. Suda, K. Ueda

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

A 30-month-old boy with hemophagocytic lymphohistiocytosis (HLH) received an autologous peripheral blood stem cell transplant (PBSCT) following high-dose chemotherapy. He presented with hemophagocytic syndrome (HPS) at 6 months of age, but relapsed despite the repeated administration of prednisolone, VP-16, cyclosporin A (CsA), and other cytotoxic agents. PBSC were obtained using combination chemotherapy with etoposide (VP16, 450 mg/m2), doxorubicin (70 mg/m2), vincristine (2 mg/m2) and cyclophosphamide (CY, 1200 mg/m2). 2.7 x 105/kg CFU-GM PBSC were transplanted after similar high-dose VP16 preconditioning used for allogeneic BMT for HLH. The boy continues to remain in complete remission 30 months after PBSCT while receiving low-dose PSL/CsA therapy. High-dose chemotherapy followed by PBSCT may be an optional therapeutic approach for patients with HLH.

Original languageEnglish
Pages (from-to)633-635
Number of pages3
JournalBone Marrow Transplantation
Volume19
Issue number6
DOIs
Publication statusPublished - Mar 2 1997

Fingerprint

Hemophagocytic Lymphohistiocytosis
Peripheral Blood Stem Cell Transplantation
Drug Therapy
Etoposide
Transplants
Cyclosporine
Granulocyte-Macrophage Progenitor Cells
Cytotoxins
Vincristine
Prednisolone
Combination Drug Therapy
Doxorubicin
Cyclophosphamide
Therapeutics
Peripheral Blood Stem Cells

All Science Journal Classification (ASJC) codes

  • Hematology
  • Transplantation

Cite this

Prolonged resolution of hemophagocytic lymphohistiocytosis following myeloablative chemotherapy and subsequent autologous peripheral blood stem cell transplantation. / Ohga, Shoichi; Nomura, A.; Kai, T.; Matsuzaki, A.; Inaba, S.; Suda, M.; Ueda, K.

In: Bone Marrow Transplantation, Vol. 19, No. 6, 02.03.1997, p. 633-635.

Research output: Contribution to journalArticle

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AU - Nomura, A.

AU - Kai, T.

AU - Matsuzaki, A.

AU - Inaba, S.

AU - Suda, M.

AU - Ueda, K.

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AB - A 30-month-old boy with hemophagocytic lymphohistiocytosis (HLH) received an autologous peripheral blood stem cell transplant (PBSCT) following high-dose chemotherapy. He presented with hemophagocytic syndrome (HPS) at 6 months of age, but relapsed despite the repeated administration of prednisolone, VP-16, cyclosporin A (CsA), and other cytotoxic agents. PBSC were obtained using combination chemotherapy with etoposide (VP16, 450 mg/m2), doxorubicin (70 mg/m2), vincristine (2 mg/m2) and cyclophosphamide (CY, 1200 mg/m2). 2.7 x 105/kg CFU-GM PBSC were transplanted after similar high-dose VP16 preconditioning used for allogeneic BMT for HLH. The boy continues to remain in complete remission 30 months after PBSCT while receiving low-dose PSL/CsA therapy. High-dose chemotherapy followed by PBSCT may be an optional therapeutic approach for patients with HLH.

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