Promoting effect of truncal vagotomy on pancreatic carcinogenesis initiated with n-nitrosobis(2-oxopropyl)amine in syrian golden hamsters

Takahiro Ogawa, Takao Makino, Kazuhiro Mizumoto, Fumio Nakayama

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

The effect of truncal vagotomy (TV) on pancreatic carcinogenesis initiated with N-nitrosobis(2-oxopropyl)amine (BOP) was investigated in 81 female Syrian golden hamsters. The animals were divided into four groups according to the treatment, groups 1 and 2 serving as non-initiated controls receiving a single s.c. injection of 0.9% NaCl followed by either a sham operation or TV respectively, at week 2. Groups 3 and 4 were given a single s.c. injection of 70 mg/kg body wt of BOP before the sham operation or TV. All hamsters were killed at week 24, and the pancreas, liver and gall bladder tissues were examined histologically. While TV itself caused no significant change in pancreatic weight, the incidence of pancreatic carcinomas in hamsters from group 4 was 48.4%, significantly higher than the 16.7% evident in hamsters from group 3 (P < 0.05). GLC analysis of the bile add composition of gall bladder bile from hamsters not receiving carcinogen 1 and 4 months after TV revealed significantly decreased secondary bile acids. The results thus indicated that changes in bile acid composition may be involved in enhancement of BOP-initiated pancreatic carcinogenesis in hamsters by TV.

Original languageEnglish
Pages (from-to)1227-1230
Number of pages4
JournalCarcinogenesis
Volume12
Issue number7
DOIs
Publication statusPublished - Jul 1 1991

All Science Journal Classification (ASJC) codes

  • Cancer Research

Fingerprint Dive into the research topics of 'Promoting effect of truncal vagotomy on pancreatic carcinogenesis initiated with n-nitrosobis(2-oxopropyl)amine in syrian golden hamsters'. Together they form a unique fingerprint.

  • Cite this