Properties and EPR studies of oligodeoxynucleotides containing 2-N-tert-butylaminoxylpurines.

Mariko Aso, Toshiyuki Kaneko, John Walter Mirc, Noboru Koga, Hiroshi Suemune

Research output: Contribution to journalArticle

Abstract

Oligodeoxynucleotide (ODN; 1) containing 2-N-tert-butylaminoxyladenosine (2) was synthesized by the conventional phosphoramidite method. The thermal stability and structure of the duplex of ODN 1 and the complementary strand were elucidated by UV-melting temperature measurements and CD experiments. In phosphate buffer, ODN 1 showed a three line EPR spectrum. Upon duplex formation, the EPR spectrum of 1 changed which indicates that EPR spectra of 1 can provide information on structures of ODN.

Original languageEnglish
Pages (from-to)3-4
Number of pages2
JournalNucleic acids symposium series (2004)
Issue number49
Publication statusPublished - Jan 1 2005

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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