Propofol anaesthesia in mice is potentiated by muscimol and reversed by bicuculline

M. Irifune, M. Sugimura, T. Takarada, K. Maeoka, Y. Shimizu, T. Dohi, T. Nishikawa, M. Kawahara

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We have examined the role of γ-aminobutyric acid (GABA) neurones in propofol anaesthesia in mice using the righting reflex. Propofol i.p. increased the percentage of loss of the righting reflex in a dose-dependent manner with an ED50 value of 140 (95% confidence limits 123-160) mg kg-1 (n = 40; eight animals per dose, five doses per dose-response curve). The ED50 for propofol decreased significantly to 66 (58-75) mg kg-1 in the presence of the GABA(A) receptor agonist muscimol mg kg-1 i.p. (n = 40) (P < 0.05). In contrast, the ED50 increased significantly to 240 (211-274) mg kg-1 in the presence of the antagonist bicuculline 5 mg kg-1 i.p. (n = 40) (P < 0.05). Our results suggest that propofol anaesthesia may be mediated, at least in part, by GABA neurones.

Original languageEnglish
Pages (from-to)665-667
Number of pages3
JournalBritish Journal of Anaesthesia
Issue number4
Publication statusPublished - Oct 1999
Externally publishedYes


All Science Journal Classification (ASJC) codes

  • Anesthesiology and Pain Medicine

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