Propranolol alone may not be acceptable to prevent first esopfaageal variceal bleeding in Japanese cirrhotic patients

Randomized controlled trial

Morimasa Tomikawa, Rinshun Shimabukuro, Keishi Okita, Norifumi Tsutsumi, Tomohiko Akahoshi, Makoto Hashizume, Keizo Sugimachi

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background and Aim: In Japan, endoscopic injection sclerotherapy (EIS) is widely used to prevent first esophageal variceal bleeding, in contrast to pharmacological therapy which is the main treatment used in the rest of the world. The present study investigated if propranolol alone is acceptable to prevent first esophageal variceal bleeding in Japanese cirrhotic patients. This was compared with EIS. Methods: Twenty-five Japanese cirrhotic patients with endoscopically proven, likely to bleed esophageal varices were randomly assigned for propranolol administration (12 patients; group A) and EIS (13 patients; group B) to prevent first esophageal variceal bleeding. Complications, non-recurrence rate, bleeding rate and probability of survival were compared between the two groups. Results: One patient in group A had severe bradycardia with loss of consciousness that seriously worsened his quality of life. The cumulative non-recurrence rate of group A was significantly lower compared with that of group B (P < 0.05). In group A, 2 of the 12 patients requested to discontinue taking propranolol and were excluded from the trial. The EIS treatment (group B) showed excellent results. No patient in group A or group B bled from esophageal varices throughout this study. The two groups showed no statistically significant differences in probability of survival. Conclusions: Propranolol alone may not be acceptable to prevent first esophageal variceal bleeding in Japanese cirrhotic patients.

Original languageEnglish
Pages (from-to)576-581
Number of pages6
JournalJournal of Gastroenterology and Hepatology (Australia)
Volume19
Issue number5
DOIs
Publication statusPublished - Jan 1 2004

Fingerprint

Propranolol
Randomized Controlled Trials
Hemorrhage
Sclerotherapy
Injections
Esophageal and Gastric Varices
Unconsciousness
Bradycardia
Japan
Therapeutics
Survival Rate
Quality of Life
Pharmacology
Survival

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Gastroenterology

Cite this

Propranolol alone may not be acceptable to prevent first esopfaageal variceal bleeding in Japanese cirrhotic patients : Randomized controlled trial. / Tomikawa, Morimasa; Shimabukuro, Rinshun; Okita, Keishi; Tsutsumi, Norifumi; Akahoshi, Tomohiko; Hashizume, Makoto; Sugimachi, Keizo.

In: Journal of Gastroenterology and Hepatology (Australia), Vol. 19, No. 5, 01.01.2004, p. 576-581.

Research output: Contribution to journalArticle

Tomikawa, Morimasa ; Shimabukuro, Rinshun ; Okita, Keishi ; Tsutsumi, Norifumi ; Akahoshi, Tomohiko ; Hashizume, Makoto ; Sugimachi, Keizo. / Propranolol alone may not be acceptable to prevent first esopfaageal variceal bleeding in Japanese cirrhotic patients : Randomized controlled trial. In: Journal of Gastroenterology and Hepatology (Australia). 2004 ; Vol. 19, No. 5. pp. 576-581.
@article{e1ffac975f3c4d18a19b5d2d88003d76,
title = "Propranolol alone may not be acceptable to prevent first esopfaageal variceal bleeding in Japanese cirrhotic patients: Randomized controlled trial",
abstract = "Background and Aim: In Japan, endoscopic injection sclerotherapy (EIS) is widely used to prevent first esophageal variceal bleeding, in contrast to pharmacological therapy which is the main treatment used in the rest of the world. The present study investigated if propranolol alone is acceptable to prevent first esophageal variceal bleeding in Japanese cirrhotic patients. This was compared with EIS. Methods: Twenty-five Japanese cirrhotic patients with endoscopically proven, likely to bleed esophageal varices were randomly assigned for propranolol administration (12 patients; group A) and EIS (13 patients; group B) to prevent first esophageal variceal bleeding. Complications, non-recurrence rate, bleeding rate and probability of survival were compared between the two groups. Results: One patient in group A had severe bradycardia with loss of consciousness that seriously worsened his quality of life. The cumulative non-recurrence rate of group A was significantly lower compared with that of group B (P < 0.05). In group A, 2 of the 12 patients requested to discontinue taking propranolol and were excluded from the trial. The EIS treatment (group B) showed excellent results. No patient in group A or group B bled from esophageal varices throughout this study. The two groups showed no statistically significant differences in probability of survival. Conclusions: Propranolol alone may not be acceptable to prevent first esophageal variceal bleeding in Japanese cirrhotic patients.",
author = "Morimasa Tomikawa and Rinshun Shimabukuro and Keishi Okita and Norifumi Tsutsumi and Tomohiko Akahoshi and Makoto Hashizume and Keizo Sugimachi",
year = "2004",
month = "1",
day = "1",
doi = "10.1111/j.1440-1746.2003.03331.x",
language = "English",
volume = "19",
pages = "576--581",
journal = "Journal of Gastroenterology and Hepatology (Australia)",
issn = "0815-9319",
publisher = "Wiley-Blackwell",
number = "5",

}

TY - JOUR

T1 - Propranolol alone may not be acceptable to prevent first esopfaageal variceal bleeding in Japanese cirrhotic patients

T2 - Randomized controlled trial

AU - Tomikawa, Morimasa

AU - Shimabukuro, Rinshun

AU - Okita, Keishi

AU - Tsutsumi, Norifumi

AU - Akahoshi, Tomohiko

AU - Hashizume, Makoto

AU - Sugimachi, Keizo

PY - 2004/1/1

Y1 - 2004/1/1

N2 - Background and Aim: In Japan, endoscopic injection sclerotherapy (EIS) is widely used to prevent first esophageal variceal bleeding, in contrast to pharmacological therapy which is the main treatment used in the rest of the world. The present study investigated if propranolol alone is acceptable to prevent first esophageal variceal bleeding in Japanese cirrhotic patients. This was compared with EIS. Methods: Twenty-five Japanese cirrhotic patients with endoscopically proven, likely to bleed esophageal varices were randomly assigned for propranolol administration (12 patients; group A) and EIS (13 patients; group B) to prevent first esophageal variceal bleeding. Complications, non-recurrence rate, bleeding rate and probability of survival were compared between the two groups. Results: One patient in group A had severe bradycardia with loss of consciousness that seriously worsened his quality of life. The cumulative non-recurrence rate of group A was significantly lower compared with that of group B (P < 0.05). In group A, 2 of the 12 patients requested to discontinue taking propranolol and were excluded from the trial. The EIS treatment (group B) showed excellent results. No patient in group A or group B bled from esophageal varices throughout this study. The two groups showed no statistically significant differences in probability of survival. Conclusions: Propranolol alone may not be acceptable to prevent first esophageal variceal bleeding in Japanese cirrhotic patients.

AB - Background and Aim: In Japan, endoscopic injection sclerotherapy (EIS) is widely used to prevent first esophageal variceal bleeding, in contrast to pharmacological therapy which is the main treatment used in the rest of the world. The present study investigated if propranolol alone is acceptable to prevent first esophageal variceal bleeding in Japanese cirrhotic patients. This was compared with EIS. Methods: Twenty-five Japanese cirrhotic patients with endoscopically proven, likely to bleed esophageal varices were randomly assigned for propranolol administration (12 patients; group A) and EIS (13 patients; group B) to prevent first esophageal variceal bleeding. Complications, non-recurrence rate, bleeding rate and probability of survival were compared between the two groups. Results: One patient in group A had severe bradycardia with loss of consciousness that seriously worsened his quality of life. The cumulative non-recurrence rate of group A was significantly lower compared with that of group B (P < 0.05). In group A, 2 of the 12 patients requested to discontinue taking propranolol and were excluded from the trial. The EIS treatment (group B) showed excellent results. No patient in group A or group B bled from esophageal varices throughout this study. The two groups showed no statistically significant differences in probability of survival. Conclusions: Propranolol alone may not be acceptable to prevent first esophageal variceal bleeding in Japanese cirrhotic patients.

UR - http://www.scopus.com/inward/record.url?scp=2442655165&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=2442655165&partnerID=8YFLogxK

U2 - 10.1111/j.1440-1746.2003.03331.x

DO - 10.1111/j.1440-1746.2003.03331.x

M3 - Article

VL - 19

SP - 576

EP - 581

JO - Journal of Gastroenterology and Hepatology (Australia)

JF - Journal of Gastroenterology and Hepatology (Australia)

SN - 0815-9319

IS - 5

ER -