Propyl gallate, a strong antioxidant, increases the ca2+ sensitivity of cardiac myofilament

Naoto Tadano, Sachio Morimoto, Fumi Takahashi-Yanaga, Yoshikazu Miwa, Iwao Ohtsuki, Toshiyuki Sasaguri

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Ca2+ sensitizers are cardiotonic agents that directly increase the Ca2+ sensitivity of cardiac myofilament. To find a novel Ca2+ sensitizer, we have screened a group of phenolic compounds by examining their effects on the Ca2+-dependent force generation in cardiac muscle fibers. We found that propyl gallate, a strong antioxidant, increased the Ca2+ sensitivity of cardiac myofilament in a dose-dependent and reversible manner. The present study indicates that propyl gallate is a novel type of Ca2+ sensitizer with antioxidant activity, which might be more beneficial for the treatment of congestive heart failure associated with oxidative stress than existing Ca2+ sensitizers.

Original languageEnglish
Pages (from-to)456-458
Number of pages3
JournalJournal of Pharmacological Sciences
Volume109
Issue number3
DOIs
Publication statusPublished - Jun 22 2009

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All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Pharmacology

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