(Pro)renin receptor in skeletal muscle is involved in the development of insulin resistance associated with postinfarct heart failure in mice

Arata Fukushima, Shintaro Kinugawa, Shingo Takada, Shoji Matsushima, Mochamad Ali Sobirin, Taisuke Ono, Masashige Takahashi, Tadashi Suga, Tsuneaki Homma, Yoshihiro Masaki, Takaaki Furihata, Tomoyasu Kadoguchi, Takashi Yokota, Koichi Okita, Hiroyuki Tsutsui

Research output: Contribution to journalArticle

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Abstract

We previously reported that insulin resistance was induced by the impairment of insulin signaling in the skeletal muscle from heart failure (HF) via NAD(P)H oxidase-dependent oxidative stress. (Pro)renin receptor [(P)RR] is involved in the activation of local renin-angiotensin system and subsequent oxidative stress. We thus examined whether (P)RR inhibitor, handle region peptide (HRP), could ameliorate insulin resistance in HF after myocardial infarction (MI) by improving oxidative stress and insulin signaling in the skeletal muscle. C57BL6J mice were divided into four groups: sham operated (Sham, n = 10), Sham treated with HRP (Sham+HRP, 0.1 mg·kg-1·day-1, n = 10), MI operated (MI, n = 10), and MI treated with HRP (MI+HRP, 0.1 mg/kg/day, n = 10). After 4 wk, MI mice showed left ventricular dysfunction, which was not affected by HRP. (P)RR was upregulated in the skeletal muscle after MI (149% of sham, P < 0.05). The decrease in plasma glucose after insulin load was smaller in MI than in Sham (21 ± 2 vs. 44 ± 3%, P < 0.05), and was greater in MI+HRP (38 ± 2%, P < 0.05) than in MI. Insulin-stimulated serine phosphorylation of Akt and glucose transporter 4 translocation were decreased in the skeletal muscle from MI by 48 and 49% of Sham, both of which were ameliorated in MI+HRP. Superoxide production and NAD(P)H oxidase activities were increased in MI, which was inhibited in MI+HRP. HRP ameliorated insulin resistance associated with HF by improving insulin signaling via the inhibition of NAD(P)H oxidase-induced superoxide production in the skeletal muscle. The (P)RR pathway is involved in the development of insulin resistance, at least in part, via the impairment of insulin signaling in the skeletal muscle from HF.

Original languageEnglish
Pages (from-to)E503-E514
JournalAmerican Journal of Physiology - Endocrinology and Metabolism
Volume307
Issue number6
DOIs
Publication statusPublished - Sep 15 2014
Externally publishedYes

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Renin
Insulin Resistance
Skeletal Muscle
Heart Failure
Myocardial Infarction
Peptides
Insulin
NADPH Oxidase
Oxidative Stress
Superoxides
Facilitative Glucose Transport Proteins
Left Ventricular Dysfunction
Renin-Angiotensin System
Serine
Phosphorylation

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Physiology
  • Physiology (medical)

Cite this

(Pro)renin receptor in skeletal muscle is involved in the development of insulin resistance associated with postinfarct heart failure in mice. / Fukushima, Arata; Kinugawa, Shintaro; Takada, Shingo; Matsushima, Shoji; Sobirin, Mochamad Ali; Ono, Taisuke; Takahashi, Masashige; Suga, Tadashi; Homma, Tsuneaki; Masaki, Yoshihiro; Furihata, Takaaki; Kadoguchi, Tomoyasu; Yokota, Takashi; Okita, Koichi; Tsutsui, Hiroyuki.

In: American Journal of Physiology - Endocrinology and Metabolism, Vol. 307, No. 6, 15.09.2014, p. E503-E514.

Research output: Contribution to journalArticle

Fukushima, A, Kinugawa, S, Takada, S, Matsushima, S, Sobirin, MA, Ono, T, Takahashi, M, Suga, T, Homma, T, Masaki, Y, Furihata, T, Kadoguchi, T, Yokota, T, Okita, K & Tsutsui, H 2014, '(Pro)renin receptor in skeletal muscle is involved in the development of insulin resistance associated with postinfarct heart failure in mice', American Journal of Physiology - Endocrinology and Metabolism, vol. 307, no. 6, pp. E503-E514. https://doi.org/10.1152/ajpendo.00449.2013
Fukushima, Arata ; Kinugawa, Shintaro ; Takada, Shingo ; Matsushima, Shoji ; Sobirin, Mochamad Ali ; Ono, Taisuke ; Takahashi, Masashige ; Suga, Tadashi ; Homma, Tsuneaki ; Masaki, Yoshihiro ; Furihata, Takaaki ; Kadoguchi, Tomoyasu ; Yokota, Takashi ; Okita, Koichi ; Tsutsui, Hiroyuki. / (Pro)renin receptor in skeletal muscle is involved in the development of insulin resistance associated with postinfarct heart failure in mice. In: American Journal of Physiology - Endocrinology and Metabolism. 2014 ; Vol. 307, No. 6. pp. E503-E514.
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AU - Matsushima, Shoji

AU - Sobirin, Mochamad Ali

AU - Ono, Taisuke

AU - Takahashi, Masashige

AU - Suga, Tadashi

AU - Homma, Tsuneaki

AU - Masaki, Yoshihiro

AU - Furihata, Takaaki

AU - Kadoguchi, Tomoyasu

AU - Yokota, Takashi

AU - Okita, Koichi

AU - Tsutsui, Hiroyuki

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