Abstract
From January 1988 to June 1992, 66 patients with resectable squamous cell carcinoma of the thoracic esophagus underwent preoperative adjuvant therapy. These patients were prospectively divided into two treatment groups; 32 were treated with radiofrequency wave local hyperthermia combined with chemoradiotherapy (hyperthermochemoradiotherapy; HCR), while the remaining 34 patients were treated with chemoradiotherapy alone (CR). There were no procedural complications in either group and the postoperative mortality was zero. In the HCR group, no viable cancer cells were found within the entire 5 mm‐width slices of the resected specimen in eight patients (25%), while only two (5.9%) in the CR group (P < 0.05) demonstrated no viable cancer cells. The cumulative 3‐year survival rate was 50.4% in the HCR group and 24.2% in the CR group. The present prospective trial demonstrated that the addition of hyperthermia to chemoradiotherapy resulted in a better local control and an improved long‐term survival when treating patients with advanced esophageal carcinoma. © 1995 Wiley‐Liss, Inc.
| Original language | English |
|---|---|
| Pages (from-to) | 55-58 |
| Number of pages | 4 |
| Journal | Journal of Surgical Oncology |
| Volume | 60 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Sep 1995 |
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All Science Journal Classification (ASJC) codes
- Surgery
- Oncology
Cite this
Prospective randomized study of hyperthermia combined with chemoradiotherapy for esophageal carcinoma. / Kitamura, Kaoru; Kuwano, Hiroyuki; Watanabe, Masayuki; Nozoe, Tadahiro; Yasuda, Mitsuhiro; Sumiyoshi, Kohei; Saku, Motonori; Sugimachi, Keizo.
In: Journal of Surgical Oncology, Vol. 60, No. 1, 09.1995, p. 55-58.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Prospective randomized study of hyperthermia combined with chemoradiotherapy for esophageal carcinoma
AU - Kitamura, Kaoru
AU - Kuwano, Hiroyuki
AU - Watanabe, Masayuki
AU - Nozoe, Tadahiro
AU - Yasuda, Mitsuhiro
AU - Sumiyoshi, Kohei
AU - Saku, Motonori
AU - Sugimachi, Keizo
PY - 1995/9
Y1 - 1995/9
N2 - From January 1988 to June 1992, 66 patients with resectable squamous cell carcinoma of the thoracic esophagus underwent preoperative adjuvant therapy. These patients were prospectively divided into two treatment groups; 32 were treated with radiofrequency wave local hyperthermia combined with chemoradiotherapy (hyperthermochemoradiotherapy; HCR), while the remaining 34 patients were treated with chemoradiotherapy alone (CR). There were no procedural complications in either group and the postoperative mortality was zero. In the HCR group, no viable cancer cells were found within the entire 5 mm‐width slices of the resected specimen in eight patients (25%), while only two (5.9%) in the CR group (P < 0.05) demonstrated no viable cancer cells. The cumulative 3‐year survival rate was 50.4% in the HCR group and 24.2% in the CR group. The present prospective trial demonstrated that the addition of hyperthermia to chemoradiotherapy resulted in a better local control and an improved long‐term survival when treating patients with advanced esophageal carcinoma. © 1995 Wiley‐Liss, Inc.
AB - From January 1988 to June 1992, 66 patients with resectable squamous cell carcinoma of the thoracic esophagus underwent preoperative adjuvant therapy. These patients were prospectively divided into two treatment groups; 32 were treated with radiofrequency wave local hyperthermia combined with chemoradiotherapy (hyperthermochemoradiotherapy; HCR), while the remaining 34 patients were treated with chemoradiotherapy alone (CR). There were no procedural complications in either group and the postoperative mortality was zero. In the HCR group, no viable cancer cells were found within the entire 5 mm‐width slices of the resected specimen in eight patients (25%), while only two (5.9%) in the CR group (P < 0.05) demonstrated no viable cancer cells. The cumulative 3‐year survival rate was 50.4% in the HCR group and 24.2% in the CR group. The present prospective trial demonstrated that the addition of hyperthermia to chemoradiotherapy resulted in a better local control and an improved long‐term survival when treating patients with advanced esophageal carcinoma. © 1995 Wiley‐Liss, Inc.
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UR - http://www.scopus.com/inward/citedby.url?scp=0029162356&partnerID=8YFLogxK
U2 - 10.1002/jso.2930600111
DO - 10.1002/jso.2930600111
M3 - Article
C2 - 7545257
AN - SCOPUS:0029162356
VL - 60
SP - 55
EP - 58
JO - Journal of Surgical Oncology
JF - Journal of Surgical Oncology
SN - 0022-4790
IS - 1
ER -