Prostaglandin D synthase (β-trace) in meningeal hemangiopericytoma

Masatou Kawashima, Satoshi O. Suzuki, Tetsumori Yamashima, Masashi Fukui, Toru Iwaki

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

The level of prostaglandin D synthase (PGDS), a major protein constituent of cerebrospinal fluid (CSF), is altered in various brain diseases, including meningitis. However, its role in the brain remains unclear. PGDS is mainly synthesized in the arachnoid cells, the choroid plexus and oligodendrocytes in the central nervous system. Among brain tumors, meningiomas showed intense immunoreactivity to PGDS in the perinuclear region. Thus, PGDS has been considered a specific cell marker of meningioma. In this study, we examined 25 meningeal hemangiopericytomas (HPCs) and found that 16 of the tumors (64%) showed immunoreactivity for PGDS in the perinuclear region. For comparison, 15 meningiomas, 14 soft-tissue HPCs, 1 mesenchymal chondrosarcoma, 3 choroid plexus papillomas, and 7 oligodendrogliomas were also examined. Meningiomas showed positive immunoreactivity for PGDS in 13 cases (80%). Except for one case located at the sacrum, none of the other soft-tissue HPCs showed immunostaining for PGDS. Mesenchymal chondrosarcoma arises in the bones of the skull, and its histological pattern resembles that of HPC; however, it showed no immunoreactivity for PGDS. Neither choroid plexus papillomas nor oligodendrogliomas were immunopositive for PGDS. These findings suggest that meningeal HPCs may have a unique molecular phenotype that is distinct from that of the soft-tissue HPCs. The origin of meningeal HPCs may be more closely related to the arachnoid cells.

Original languageEnglish
Pages (from-to)197-201
Number of pages5
JournalModern Pathology
Volume14
Issue number3
DOIs
Publication statusPublished - Apr 10 2001

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prostaglandin R2 D-isomerase
Hemangiopericytoma
Meningioma
Mesenchymal Chondrosarcoma
Choroid Plexus Papilloma
Arachnoid
Oligodendroglioma
Cerebrospinal Fluid Proteins
Sacrum
Choroid Plexus
Oligodendroglia
Brain Diseases
Meningitis
Skull
Brain Neoplasms

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine

Cite this

Prostaglandin D synthase (β-trace) in meningeal hemangiopericytoma. / Kawashima, Masatou; Suzuki, Satoshi O.; Yamashima, Tetsumori; Fukui, Masashi; Iwaki, Toru.

In: Modern Pathology, Vol. 14, No. 3, 10.04.2001, p. 197-201.

Research output: Contribution to journalArticle

Kawashima, Masatou ; Suzuki, Satoshi O. ; Yamashima, Tetsumori ; Fukui, Masashi ; Iwaki, Toru. / Prostaglandin D synthase (β-trace) in meningeal hemangiopericytoma. In: Modern Pathology. 2001 ; Vol. 14, No. 3. pp. 197-201.
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