Prostaglandin E Receptor Subtypes EP2 and EP4 Promote TH1 Cell Differentiation and TH17 Cell Expansion Through Different Signaling Modules

Daiji Sakata, Chengcan Yao, Yoshiyasu Esaki, Youxian Li, Toshiyuki Matsuoka, Kenji Kuroiwa, Yukihiko Sugimoto, Shuh Narumiya

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


It is well known that prostaglandin (PG) E2 exerts T cell suppression in vitro through elevating cAMP by its receptors, EP2 and EP4. However, such an action is rarely detected in vivo, leaving PGE2-mediated immunosuppression an enigma. Here we show that under strong TCR stimulation, PGE2 facilitates T helper-1 (TH-1) differentiation through activation of phosphatidylinositol-3-kinase (PI3K) by EP2 and EP4. The PGE2-EP4 signaling is also required for IL-23 production by activated dendritic cells (DCs), and the PGE2-EP2/EP4 signaling amplifies IL-23-mediated TH-17 cell expansion. Administration of an EP4-selective antagonist in vivo to mice subjected to experimental allergic encephalomyelitis (EAE) decreases accumulation of both TH-1 and TH-17 cells in regional lymph nodes, and suppresses the disease progression. These results suggest PGE2 promotes immune inflammation through TH-1 differentiation and TH-17 expansion and the EP4 antagonism is therapeutically useful for various immune diseases.

Original languageEnglish
Pages (from-to)S244-S248
JournalInflammation Research
Issue number2
Publication statusPublished - 2009
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Immunology
  • Pharmacology


Dive into the research topics of 'Prostaglandin E Receptor Subtypes EP2 and EP4 Promote T<sub>H</sub>1 Cell Differentiation and T<sub>H</sub>17 Cell Expansion Through Different Signaling Modules'. Together they form a unique fingerprint.

Cite this