Prostaglandin E1 protects against liver injury induced by Escherichia coli infection via a dominant Th2-like response of liver T cells in mice

Yasuji Mokuno, Manabu Takano, Tetsuya Matsuguchi, Hitoshi Nishimura, Junji Washizu, Yoshikazu Naiki, Yuji Nlmura, Yasunobu Yoshikai

    Research output: Contribution to journalArticle

    18 Citations (Scopus)

    Abstract

    Prostaglandin E series (PGEs) are known to protect against lipopolysaccharide (LPS)-induced liver injury by down-regulating the production of inflammatory cytokines. We show here a novel mechanism whereby prostaglandin E1 protects mice against liver injury after Escherichia coli infection. Prostaglandin E1 administration suppressed circulating interleukin 12 (IL-12) levels but increased the IL-10 production after E. coli challenge. Furthermore, prostaglandin E1-α-cyclodextrin (PGE1) shifted the Th1/Th2 balance of CD3(intermediate) IL-2Rβ+ T cells in the liver to a dominant Th2-like response. Neutralization of endogenous IL-4 by administration of anti-IL-4 monoclonal antibody (mAb) diminished the inhibitory effect of prostaglandin E1 on liver injury after E. coli challenge. These results suggested that the Th2-like response of liver T cells may be at least partly involved in the mechanism whereby prostaglandin E1 protects against E. coli-induced liver injury.

    Original languageEnglish
    Pages (from-to)1464-1472
    Number of pages9
    JournalHepatology
    Volume30
    Issue number6
    DOIs
    Publication statusPublished - Jan 1 1999

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    Escherichia coli Infections
    Alprostadil
    T-Lymphocytes
    Liver
    Wounds and Injuries
    Escherichia coli
    Prostaglandins E
    Interleukin-4
    Th1-Th2 Balance
    Cyclodextrins
    Interleukin-12
    Interleukin-10
    Lipopolysaccharides
    Monoclonal Antibodies
    Cytokines

    All Science Journal Classification (ASJC) codes

    • Hepatology

    Cite this

    Mokuno, Y., Takano, M., Matsuguchi, T., Nishimura, H., Washizu, J., Naiki, Y., ... Yoshikai, Y. (1999). Prostaglandin E1 protects against liver injury induced by Escherichia coli infection via a dominant Th2-like response of liver T cells in mice. Hepatology, 30(6), 1464-1472. https://doi.org/10.1002/hep.510300606

    Prostaglandin E1 protects against liver injury induced by Escherichia coli infection via a dominant Th2-like response of liver T cells in mice. / Mokuno, Yasuji; Takano, Manabu; Matsuguchi, Tetsuya; Nishimura, Hitoshi; Washizu, Junji; Naiki, Yoshikazu; Nlmura, Yuji; Yoshikai, Yasunobu.

    In: Hepatology, Vol. 30, No. 6, 01.01.1999, p. 1464-1472.

    Research output: Contribution to journalArticle

    Mokuno, Y, Takano, M, Matsuguchi, T, Nishimura, H, Washizu, J, Naiki, Y, Nlmura, Y & Yoshikai, Y 1999, 'Prostaglandin E1 protects against liver injury induced by Escherichia coli infection via a dominant Th2-like response of liver T cells in mice', Hepatology, vol. 30, no. 6, pp. 1464-1472. https://doi.org/10.1002/hep.510300606
    Mokuno, Yasuji ; Takano, Manabu ; Matsuguchi, Tetsuya ; Nishimura, Hitoshi ; Washizu, Junji ; Naiki, Yoshikazu ; Nlmura, Yuji ; Yoshikai, Yasunobu. / Prostaglandin E1 protects against liver injury induced by Escherichia coli infection via a dominant Th2-like response of liver T cells in mice. In: Hepatology. 1999 ; Vol. 30, No. 6. pp. 1464-1472.
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