Prostaglandin E1 protects against liver injury induced by Escherichia coli infection via a dominant Th2-like response of liver T cells in mice

Yasuji Mokuno, Manabu Takano, Tetsuya Matsuguchi, Hitoshi Nishimura, Junji Washizu, Yoshikazu Naiki, Yuji Nlmura, Yasunobu Yoshikai

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    Abstract

    Prostaglandin E series (PGEs) are known to protect against lipopolysaccharide (LPS)-induced liver injury by down-regulating the production of inflammatory cytokines. We show here a novel mechanism whereby prostaglandin E1 protects mice against liver injury after Escherichia coli infection. Prostaglandin E1 administration suppressed circulating interleukin 12 (IL-12) levels but increased the IL-10 production after E. coli challenge. Furthermore, prostaglandin E1-α-cyclodextrin (PGE1) shifted the Th1/Th2 balance of CD3(intermediate) IL-2Rβ+ T cells in the liver to a dominant Th2-like response. Neutralization of endogenous IL-4 by administration of anti-IL-4 monoclonal antibody (mAb) diminished the inhibitory effect of prostaglandin E1 on liver injury after E. coli challenge. These results suggested that the Th2-like response of liver T cells may be at least partly involved in the mechanism whereby prostaglandin E1 protects against E. coli-induced liver injury.

    Original languageEnglish
    Pages (from-to)1464-1472
    Number of pages9
    JournalHepatology
    Volume30
    Issue number6
    DOIs
    Publication statusPublished - Jan 1 1999

    All Science Journal Classification (ASJC) codes

    • Hepatology

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    Mokuno, Y., Takano, M., Matsuguchi, T., Nishimura, H., Washizu, J., Naiki, Y., Nlmura, Y., & Yoshikai, Y. (1999). Prostaglandin E1 protects against liver injury induced by Escherichia coli infection via a dominant Th2-like response of liver T cells in mice. Hepatology, 30(6), 1464-1472. https://doi.org/10.1002/hep.510300606