Protease-triggered targeted delivery of gold nanorods into tumor

Takuro Niidome, Akira Ohga, Tsuyoshi Ando, Yasuro Niidome, Takeshi Mori, Yoshiki Katayama

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Gold nanorods have a strong surface plasmon band at the near infrared region. The absorbed light energy is then converted to heat. Since near infrared light can penetrate deeply into tissue, gold nanorods are expected to be used as a contrast agent for bioimaging using the near infrared light and photosensitizers for photothermal therapy. In this study, to achieve targeted delivery of the gold nanorods to tumor, PEG-peptide-modified gold nanorods were constructed. As the peptide part, substrate sequences for proteases that are specifically expressed in tumor were employed. After reacting with the proteases, dramatic spectral changes were observed, indicating that aggregation of the gold nanorods occurred. The aggregation depended on density of the modified PEG-peptide on the surface of the gold nanorods. When the gold nanorods were injected into tumor-bearing mice, higher accumulation of the gold nanorods in the tumor was detected compared with the case of PEG-peptide (control sequence)-modified gold nanorods. Use of peptide sensing extracellular matrix of tumor is expected to be a powerful strategy for diagnosis and therapy of tumor using gold nanorods.

Original languageEnglish
Title of host publicationBiological Imaging and Sensing Using Nanoparticle Assemblies
Pages84-88
Number of pages5
Volume1241
Publication statusPublished - 2010
Event2009 MRS Fall Meeting - Boston, MA, United States
Duration: Nov 30 2009Dec 2 2009

Other

Other2009 MRS Fall Meeting
CountryUnited States
CityBoston, MA
Period11/30/0912/2/09

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All Science Journal Classification (ASJC) codes

  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanical Engineering
  • Mechanics of Materials

Cite this

Niidome, T., Ohga, A., Ando, T., Niidome, Y., Mori, T., & Katayama, Y. (2010). Protease-triggered targeted delivery of gold nanorods into tumor. In Biological Imaging and Sensing Using Nanoparticle Assemblies (Vol. 1241, pp. 84-88)