Protective effect of Toki-shakuyaku-san on amyloid β25-35- induced neuronal damage in cultured rat cortical neurons

Nobuaki Egashira, Katsunori Iwasaki, Yuki Akiyoshi, Yuki Takagaki, Izzettin Hatip-Al-Khatib, Kenichi Mishima, Kouji Kurauchi, Tomoaki Ikeda, Michihiro Fujiwara

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Amyloid β protein (Aβ) is the major component of senile plaques, the pathological hallmark of the neurodegeneration associated with Alzheimer's disease (AD). This study investigated the effect of Toki-shakuyaku-san (TSS), a traditional medicine, on Aβ25-35-induced neuronal death and lipid peroxidation assessed by measuring lactate dehydrogenase (LDH) and malondialdehyde (MDA), respectively. Aβ25-35 at 10 μM induced neuronal damage and increased the LDH and MDA. TSS at concentrations of 100 and 300 μg/mL significantly reduced the Aβ25-35-induced neuronal death and the lipid peroxidation. These results suggest that TSS has a protective effect against Aβ25-35-induced neuronal damage. TSS may be beneficial for the treatment of AD.

Original languageEnglish
Pages (from-to)450-453
Number of pages4
JournalPhytotherapy Research
Volume19
Issue number5
DOIs
Publication statusPublished - May 1 2005
Externally publishedYes

Fingerprint

Amyloid
Neurons
Rats
Malondialdehyde
L-Lactate Dehydrogenase
Lipid Peroxidation
Alzheimer Disease
Lipids
Serum Amyloid A Protein
Amyloid Plaques
Traditional Medicine
Medicine
toki-shakuyaku-san
Therapeutics

All Science Journal Classification (ASJC) codes

  • Drug Discovery
  • Organic Chemistry
  • Pharmacology

Cite this

Egashira, N., Iwasaki, K., Akiyoshi, Y., Takagaki, Y., Hatip-Al-Khatib, I., Mishima, K., ... Fujiwara, M. (2005). Protective effect of Toki-shakuyaku-san on amyloid β25-35- induced neuronal damage in cultured rat cortical neurons. Phytotherapy Research, 19(5), 450-453. https://doi.org/10.1002/ptr.1671

Protective effect of Toki-shakuyaku-san on amyloid β25-35- induced neuronal damage in cultured rat cortical neurons. / Egashira, Nobuaki; Iwasaki, Katsunori; Akiyoshi, Yuki; Takagaki, Yuki; Hatip-Al-Khatib, Izzettin; Mishima, Kenichi; Kurauchi, Kouji; Ikeda, Tomoaki; Fujiwara, Michihiro.

In: Phytotherapy Research, Vol. 19, No. 5, 01.05.2005, p. 450-453.

Research output: Contribution to journalArticle

Egashira, N, Iwasaki, K, Akiyoshi, Y, Takagaki, Y, Hatip-Al-Khatib, I, Mishima, K, Kurauchi, K, Ikeda, T & Fujiwara, M 2005, 'Protective effect of Toki-shakuyaku-san on amyloid β25-35- induced neuronal damage in cultured rat cortical neurons', Phytotherapy Research, vol. 19, no. 5, pp. 450-453. https://doi.org/10.1002/ptr.1671
Egashira, Nobuaki ; Iwasaki, Katsunori ; Akiyoshi, Yuki ; Takagaki, Yuki ; Hatip-Al-Khatib, Izzettin ; Mishima, Kenichi ; Kurauchi, Kouji ; Ikeda, Tomoaki ; Fujiwara, Michihiro. / Protective effect of Toki-shakuyaku-san on amyloid β25-35- induced neuronal damage in cultured rat cortical neurons. In: Phytotherapy Research. 2005 ; Vol. 19, No. 5. pp. 450-453.
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