TY - JOUR
T1 - Protective effect of Toki-shakuyaku-san on amyloid β25-35- induced neuronal damage in cultured rat cortical neurons
AU - Egashira, Nobuaki
AU - Iwasaki, Katsunori
AU - Akiyoshi, Yuki
AU - Takagaki, Yuki
AU - Hatip-Al-Khatib, Izzettin
AU - Mishima, Kenichi
AU - Kurauchi, Kouji
AU - Ikeda, Tomoaki
AU - Fujiwara, Michihiro
PY - 2005/5/1
Y1 - 2005/5/1
N2 - Amyloid β protein (Aβ) is the major component of senile plaques, the pathological hallmark of the neurodegeneration associated with Alzheimer's disease (AD). This study investigated the effect of Toki-shakuyaku-san (TSS), a traditional medicine, on Aβ25-35-induced neuronal death and lipid peroxidation assessed by measuring lactate dehydrogenase (LDH) and malondialdehyde (MDA), respectively. Aβ25-35 at 10 μM induced neuronal damage and increased the LDH and MDA. TSS at concentrations of 100 and 300 μg/mL significantly reduced the Aβ25-35-induced neuronal death and the lipid peroxidation. These results suggest that TSS has a protective effect against Aβ25-35-induced neuronal damage. TSS may be beneficial for the treatment of AD.
AB - Amyloid β protein (Aβ) is the major component of senile plaques, the pathological hallmark of the neurodegeneration associated with Alzheimer's disease (AD). This study investigated the effect of Toki-shakuyaku-san (TSS), a traditional medicine, on Aβ25-35-induced neuronal death and lipid peroxidation assessed by measuring lactate dehydrogenase (LDH) and malondialdehyde (MDA), respectively. Aβ25-35 at 10 μM induced neuronal damage and increased the LDH and MDA. TSS at concentrations of 100 and 300 μg/mL significantly reduced the Aβ25-35-induced neuronal death and the lipid peroxidation. These results suggest that TSS has a protective effect against Aβ25-35-induced neuronal damage. TSS may be beneficial for the treatment of AD.
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U2 - 10.1002/ptr.1671
DO - 10.1002/ptr.1671
M3 - Article
C2 - 16106382
AN - SCOPUS:24644504769
VL - 19
SP - 450
EP - 453
JO - Phytotherapy Research
JF - Phytotherapy Research
SN - 0951-418X
IS - 5
ER -