Protective effect of Toki-shakuyaku-san on amyloid β25-35- induced neuronal damage in cultured rat cortical neurons

Nobuaki Egashira; Katsunori Iwasaki; Yuki Akiyoshi; Yuki Takagaki; Izzettin Hatip-Al-Khatib; Kenichi Mishima; Kouji Kurauchi; Tomoaki Ikeda; Michihiro Fujiwara

doi:10.1002/ptr.1671

Protective effect of Toki-shakuyaku-san on amyloid β_25-35- induced neuronal damage in cultured rat cortical neurons

Nobuaki Egashira, Katsunori Iwasaki, Yuki Akiyoshi, Yuki Takagaki, Izzettin Hatip-Al-Khatib, Kenichi Mishima, Kouji Kurauchi, Tomoaki Ikeda, Michihiro Fujiwara

Research output: Contribution to journal › Article › peer-review

31 Citations (Scopus)

Abstract

Amyloid β protein (Aβ) is the major component of senile plaques, the pathological hallmark of the neurodegeneration associated with Alzheimer's disease (AD). This study investigated the effect of Toki-shakuyaku-san (TSS), a traditional medicine, on Aβ_25-35-induced neuronal death and lipid peroxidation assessed by measuring lactate dehydrogenase (LDH) and malondialdehyde (MDA), respectively. Aβ_25-35 at 10 μM induced neuronal damage and increased the LDH and MDA. TSS at concentrations of 100 and 300 μg/mL significantly reduced the Aβ_25-35-induced neuronal death and the lipid peroxidation. These results suggest that TSS has a protective effect against Aβ_25-35-induced neuronal damage. TSS may be beneficial for the treatment of AD.

Original language	English
Pages (from-to)	450-453
Number of pages	4
Journal	Phytotherapy Research
Volume	19
Issue number	5
DOIs	https://doi.org/10.1002/ptr.1671
Publication status	Published - May 1 2005
Externally published	Yes

All Science Journal Classification (ASJC) codes

Pharmacology

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Protective effect of Toki-shakuyaku-san on amyloid β_25-35- induced neuronal damage in cultured rat cortical neurons. / Egashira, Nobuaki; Iwasaki, Katsunori; Akiyoshi, Yuki; Takagaki, Yuki; Hatip-Al-Khatib, Izzettin; Mishima, Kenichi; Kurauchi, Kouji; Ikeda, Tomoaki; Fujiwara, Michihiro.

In: Phytotherapy Research, Vol. 19, No. 5, 01.05.2005, p. 450-453.

Research output: Contribution to journal › Article › peer-review

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AU - Akiyoshi, Yuki

AU - Takagaki, Yuki

AU - Hatip-Al-Khatib, Izzettin

AU - Mishima, Kenichi

AU - Kurauchi, Kouji

AU - Ikeda, Tomoaki

AU - Fujiwara, Michihiro

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AB - Amyloid β protein (Aβ) is the major component of senile plaques, the pathological hallmark of the neurodegeneration associated with Alzheimer's disease (AD). This study investigated the effect of Toki-shakuyaku-san (TSS), a traditional medicine, on Aβ25-35-induced neuronal death and lipid peroxidation assessed by measuring lactate dehydrogenase (LDH) and malondialdehyde (MDA), respectively. Aβ25-35 at 10 μM induced neuronal damage and increased the LDH and MDA. TSS at concentrations of 100 and 300 μg/mL significantly reduced the Aβ25-35-induced neuronal death and the lipid peroxidation. These results suggest that TSS has a protective effect against Aβ25-35-induced neuronal damage. TSS may be beneficial for the treatment of AD.

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Protective effect of Toki-shakuyaku-san on amyloid β_25-35- induced neuronal damage in cultured rat cortical neurons

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