Mice with retrovirus-induced murine acquired immunodeficiency syndrome (MAIDS) were hypersensitive to lipopolysaccharide (LPS)-induced lethal shock accompanied by marked elevations of systemic interleukin 1β (IL-β) and interferon γ (IFN-γ) after LPS challenge. Pretreatment with 10 μg of recombinant human granulocyte colony-stimulating factor (rhG-CSF) protected MAIDS mice from hypersensitivity to LPS-induced lethal shock and this protection was concomitant with suppression of IFN-γ production.
All Science Journal Classification (ASJC) codes
- Immunology and Allergy
- Molecular Biology