Protective effects of granulocyte colony-stimulating factor on endotoxin shock in mice with retrovirus-induced immunodeficiency syndrome

Sachie Toki, Kenji Hiromatsu, Yoshiyasu Aoki, Masahiko Makino, Yasunobu Yoshikai

    Research output: Contribution to journalArticlepeer-review

    4 Citations (Scopus)

    Abstract

    Mice with retrovirus-induced murine acquired immunodeficiency syndrome (MAIDS) were hypersensitive to lipopolysaccharide (LPS)-induced lethal shock accompanied by marked elevations of systemic interleukin 1β (IL-β) and interferon γ (IFN-γ) after LPS challenge. Pretreatment with 10 μg of recombinant human granulocyte colony-stimulating factor (rhG-CSF) protected MAIDS mice from hypersensitivity to LPS-induced lethal shock and this protection was concomitant with suppression of IFN-γ production.

    Original languageEnglish
    Pages (from-to)781-786
    Number of pages6
    JournalCytokine
    Volume9
    Issue number10
    DOIs
    Publication statusPublished - Oct 1997

    All Science Journal Classification (ASJC) codes

    • Immunology and Allergy
    • Immunology
    • Biochemistry
    • Hematology
    • Molecular Biology

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