Protective immunity to Listeria monocytogenes in neonatally thymectomized (NTx) mice

Involvement of T cells distinct from those in sham-thymectomized mice

Y. Watanabe, M. Mitsuyama, T. Koga, T. Handa, Y. Yoshikai, K. Nomoto

    Research output: Contribution to journalArticle

    1 Citation (Scopus)

    Abstract

    Neonatally thymectomized (NTx) mice, whose ability to mount antigen-specific cell-mediated immunity is reported to be generally defective, were found to be capable of mounting a normal level of acquired cellular resistance (ACR) and delayed footpad reaction (DFR) to Listeria monocytogenes. The present study was done in order to determine the functional differences of T cells contributing to the protection against L. monocytogenes between NTx and sham-operated mice. In mice immunized with viable L. monocytogenes, the absolute number of splenic T cells was significantly lower in NTx mice compared with sham-operated mice. When the ability of immune T cells to transfer ACR and DFR was examined by passive transfer, lymphocytes from immune NTx mice conferred a higher level of ACR and DFR on naive recipient mice, despite the marked difference in total number of T cells compared with immune Sham mice. Antigen-specific proliferation and interleukin-2 (IL-2) production by splenic T cells from immune NTx mice were significantly lower than in those from immune Sham mice. The proliferative response of T cells to exogenous IL-2 was also lower in NTx group. These results suggest that the requirement for the IL-2-driven T-cell proliferation system is basically low in the generation of effector T cells specific for L. monocytogenes.

    Original languageEnglish
    Pages (from-to)649-655
    Number of pages7
    JournalImmunology
    Volume63
    Issue number4
    Publication statusPublished - Jan 1 1988

    Fingerprint

    Listeria monocytogenes
    Immunity
    T-Lymphocytes
    Interleukin-2
    Antigens
    Cellular Immunity
    Cell Proliferation
    Lymphocytes

    All Science Journal Classification (ASJC) codes

    • Immunology and Allergy
    • Immunology

    Cite this

    Protective immunity to Listeria monocytogenes in neonatally thymectomized (NTx) mice : Involvement of T cells distinct from those in sham-thymectomized mice. / Watanabe, Y.; Mitsuyama, M.; Koga, T.; Handa, T.; Yoshikai, Y.; Nomoto, K.

    In: Immunology, Vol. 63, No. 4, 01.01.1988, p. 649-655.

    Research output: Contribution to journalArticle

    Watanabe, Y, Mitsuyama, M, Koga, T, Handa, T, Yoshikai, Y & Nomoto, K 1988, 'Protective immunity to Listeria monocytogenes in neonatally thymectomized (NTx) mice: Involvement of T cells distinct from those in sham-thymectomized mice', Immunology, vol. 63, no. 4, pp. 649-655.
    Watanabe, Y. ; Mitsuyama, M. ; Koga, T. ; Handa, T. ; Yoshikai, Y. ; Nomoto, K. / Protective immunity to Listeria monocytogenes in neonatally thymectomized (NTx) mice : Involvement of T cells distinct from those in sham-thymectomized mice. In: Immunology. 1988 ; Vol. 63, No. 4. pp. 649-655.
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    abstract = "Neonatally thymectomized (NTx) mice, whose ability to mount antigen-specific cell-mediated immunity is reported to be generally defective, were found to be capable of mounting a normal level of acquired cellular resistance (ACR) and delayed footpad reaction (DFR) to Listeria monocytogenes. The present study was done in order to determine the functional differences of T cells contributing to the protection against L. monocytogenes between NTx and sham-operated mice. In mice immunized with viable L. monocytogenes, the absolute number of splenic T cells was significantly lower in NTx mice compared with sham-operated mice. When the ability of immune T cells to transfer ACR and DFR was examined by passive transfer, lymphocytes from immune NTx mice conferred a higher level of ACR and DFR on naive recipient mice, despite the marked difference in total number of T cells compared with immune Sham mice. Antigen-specific proliferation and interleukin-2 (IL-2) production by splenic T cells from immune NTx mice were significantly lower than in those from immune Sham mice. The proliferative response of T cells to exogenous IL-2 was also lower in NTx group. These results suggest that the requirement for the IL-2-driven T-cell proliferation system is basically low in the generation of effector T cells specific for L. monocytogenes.",
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