Protective role of peroxisome proliferator-activated receptor α agonists in skin barrier and inflammation

Kazuhisa Furue; Chikage Mitoma; Gaku Tsuji; Masutaka Furue

doi:10.1016/j.imbio.2017.10.047

Protective role of peroxisome proliferator-activated receptor α agonists in skin barrier and inflammation

Kazuhisa Furue, Chikage Mitoma, Gaku Tsuji, Masutaka Furue

Research output: Contribution to journal › Review article › peer-review

14 Citations (Scopus)

Abstract

Peroxisome proliferator-activated receptor α (PPARα) is one of the three isoforms of PPARs, which are ligand-activated nuclear transcription factors. PPARα is highly expressed in liver and its agonists are widely used to treat hyperlipidemia. Epidermal keratinocytes express all three isoforms (α, β/δ, and γ) of PPARs and PPARα is particularly important for regulating the epidermal barrier and inflammation. Agonistic ligation of PPARα protects the epidermal barrier function and inhibits the inflammatory response in dermatitis. In this review, we summarize recent topics on the role of PPARα in skin biology and discuss the potential use of topical PPARα agonists for treating atopic dermatitis and other eczemas.

Original language	English
Pages (from-to)	327-330
Number of pages	4
Journal	Immunobiology
Volume	223
Issue number	3
DOIs	https://doi.org/10.1016/j.imbio.2017.10.047
Publication status	Published - Mar 2018

All Science Journal Classification (ASJC) codes

Immunology and Allergy
Immunology
Hematology

Access to Document

10.1016/j.imbio.2017.10.047

Cite this

@article{f2c6fd1e2d7a428798885dd47655517d,

title = "Protective role of peroxisome proliferator-activated receptor α agonists in skin barrier and inflammation",

abstract = "Peroxisome proliferator-activated receptor α (PPARα) is one of the three isoforms of PPARs, which are ligand-activated nuclear transcription factors. PPARα is highly expressed in liver and its agonists are widely used to treat hyperlipidemia. Epidermal keratinocytes express all three isoforms (α, β/δ, and γ) of PPARs and PPARα is particularly important for regulating the epidermal barrier and inflammation. Agonistic ligation of PPARα protects the epidermal barrier function and inhibits the inflammatory response in dermatitis. In this review, we summarize recent topics on the role of PPARα in skin biology and discuss the potential use of topical PPARα agonists for treating atopic dermatitis and other eczemas.",

author = "Kazuhisa Furue and Chikage Mitoma and Gaku Tsuji and Masutaka Furue",

note = "Funding Information: This work was partly supported by a grant ( H27-Shokuhin-Shitei-017 ) for Research on Food Safety from The Ministry of Health, Labour and Welfare, Japan . Publisher Copyright: {\textcopyright} 2017 Elsevier GmbH",

year = "2018",

month = mar,

doi = "10.1016/j.imbio.2017.10.047",

language = "English",

volume = "223",

pages = "327--330",

journal = "Immunobiology",

issn = "0171-2985",

publisher = "Urban und Fischer Verlag GmbH und Co. KG",

number = "3",

}

TY - JOUR

T1 - Protective role of peroxisome proliferator-activated receptor α agonists in skin barrier and inflammation

AU - Furue, Kazuhisa

AU - Mitoma, Chikage

AU - Tsuji, Gaku

AU - Furue, Masutaka

N1 - Funding Information: This work was partly supported by a grant ( H27-Shokuhin-Shitei-017 ) for Research on Food Safety from The Ministry of Health, Labour and Welfare, Japan . Publisher Copyright: © 2017 Elsevier GmbH

PY - 2018/3

Y1 - 2018/3

N2 - Peroxisome proliferator-activated receptor α (PPARα) is one of the three isoforms of PPARs, which are ligand-activated nuclear transcription factors. PPARα is highly expressed in liver and its agonists are widely used to treat hyperlipidemia. Epidermal keratinocytes express all three isoforms (α, β/δ, and γ) of PPARs and PPARα is particularly important for regulating the epidermal barrier and inflammation. Agonistic ligation of PPARα protects the epidermal barrier function and inhibits the inflammatory response in dermatitis. In this review, we summarize recent topics on the role of PPARα in skin biology and discuss the potential use of topical PPARα agonists for treating atopic dermatitis and other eczemas.

AB - Peroxisome proliferator-activated receptor α (PPARα) is one of the three isoforms of PPARs, which are ligand-activated nuclear transcription factors. PPARα is highly expressed in liver and its agonists are widely used to treat hyperlipidemia. Epidermal keratinocytes express all three isoforms (α, β/δ, and γ) of PPARs and PPARα is particularly important for regulating the epidermal barrier and inflammation. Agonistic ligation of PPARα protects the epidermal barrier function and inhibits the inflammatory response in dermatitis. In this review, we summarize recent topics on the role of PPARα in skin biology and discuss the potential use of topical PPARα agonists for treating atopic dermatitis and other eczemas.

UR - http://www.scopus.com/inward/record.url?scp=85032212999&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85032212999&partnerID=8YFLogxK

U2 - 10.1016/j.imbio.2017.10.047

DO - 10.1016/j.imbio.2017.10.047

M3 - Review article

C2 - 29111315

AN - SCOPUS:85032212999

SN - 0171-2985

VL - 223

SP - 327

EP - 330

JO - Immunobiology

JF - Immunobiology

IS - 3

ER -

Protective role of peroxisome proliferator-activated receptor α agonists in skin barrier and inflammation

Abstract

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this