Protein-bound polysaccharide decreases invasiveness and proliferation in pancreatic cancer by inhibition of hedgehog signaling and HIF-1α pathways under hypoxia

Hideya Ohnishi, Takafumi Morisaki, Fumihiko Nakao, Seiichi Odate, Takashi Morisaki, Mitsuo Katano

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

To develop an effective therapeutic approach to pancreatic ductal adenocarcinoma (PDAC), we focused on the antitumor mechanism of protein-bound polysaccharide (PSK) under hypoxia. PSK decreased proliferation in PDAC cells under hypoxia but not normoxia. PSK also showed anti-tumor effects in vivo, inhibited invasiveness of PDAC cells, and decreased the expression of HIF-1α and hedgehog (Hh) signaling-related molecules under hypoxia. Inhibition of HIF-1α and Hh signaling reduced proliferation and invasiveness in PDAC cells under hypoxia. In conclusion, we found new PSK-related pathways in invasiveness and proliferation in PDAC under hypoxia. PSK may be a promising therapeutic drug to treat refractory PDAC.

Original languageEnglish
Pages (from-to)289-298
Number of pages10
JournalCancer Letters
Volume335
Issue number2
DOIs
Publication statusPublished - Jul 28 2013

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Pancreatic Neoplasms
Polysaccharides
Adenocarcinoma
Cell Hypoxia
Proteins
Hypoxia
krestin
Therapeutics
Pharmaceutical Preparations
Neoplasms

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Protein-bound polysaccharide decreases invasiveness and proliferation in pancreatic cancer by inhibition of hedgehog signaling and HIF-1α pathways under hypoxia. / Ohnishi, Hideya; Morisaki, Takafumi; Nakao, Fumihiko; Odate, Seiichi; Morisaki, Takashi; Katano, Mitsuo.

In: Cancer Letters, Vol. 335, No. 2, 28.07.2013, p. 289-298.

Research output: Contribution to journalArticle

Ohnishi, Hideya ; Morisaki, Takafumi ; Nakao, Fumihiko ; Odate, Seiichi ; Morisaki, Takashi ; Katano, Mitsuo. / Protein-bound polysaccharide decreases invasiveness and proliferation in pancreatic cancer by inhibition of hedgehog signaling and HIF-1α pathways under hypoxia. In: Cancer Letters. 2013 ; Vol. 335, No. 2. pp. 289-298.
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