Protein-bound polysaccharide-K reduces colitic tumors and improves survival of inflammatory bowel disease in vivo

Norifumi Tsutsumi, Shunji Kohnoe, Hideto Sonoda, Atsushi Guntani, Tatsuya Rikimaru, Ken Ichi Taguchi, Morimasa Tomikawa, Yoshihiro Kakeji, Hideaki Nakashima, Yoshihiko Maehara

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Protein-bound polysaccharide-K (PSK) is a biological response modifier that possesses antitumor effects against various tumors. Although an inflammatory response has been considered to play an important role in the development of colorectal cancer, the anti-inflammatory effect of PSK has yet to be elucidated. An inflammatory bowel disease (IBD)-induced colorectal tumor model with 1.2-dimethyl hydrazine (DMH) and dextran sodium sulfate (DSS) was used to examine the effects of PSK on tumor suppression and survival. Although 90% of the mice that were not treated with PSK developed colitic tumors, oral administration of PSK suppressed tumor formation by less than 30%. Although deaths associated with DSS-induced melena were observed, PSK significantly reduced mortality. In conclusion, the present study showed that PSK not only suppressed colorectal tumor formation in the DMH+DSS-induced IBD model, but also improved the survival rate, indicating that anti-inflammatory activity is one of the mechanisms for the antitumor effects of PSK.

Original languageEnglish
Pages (from-to)791-796
Number of pages6
JournalOncology Letters
Volume2
Issue number5
DOIs
Publication statusPublished - Sep 1 2011

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Inflammatory Bowel Diseases
hydrazine
Dextran Sulfate
Neoplasms
Proteins
Colorectal Neoplasms
Anti-Inflammatory Agents
Melena
krestin
Immunologic Factors
Oral Administration
Survival Rate
Mortality

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Tsutsumi, N., Kohnoe, S., Sonoda, H., Guntani, A., Rikimaru, T., Taguchi, K. I., ... Maehara, Y. (2011). Protein-bound polysaccharide-K reduces colitic tumors and improves survival of inflammatory bowel disease in vivo. Oncology Letters, 2(5), 791-796. https://doi.org/10.3892/ol.2011.336

Protein-bound polysaccharide-K reduces colitic tumors and improves survival of inflammatory bowel disease in vivo. / Tsutsumi, Norifumi; Kohnoe, Shunji; Sonoda, Hideto; Guntani, Atsushi; Rikimaru, Tatsuya; Taguchi, Ken Ichi; Tomikawa, Morimasa; Kakeji, Yoshihiro; Nakashima, Hideaki; Maehara, Yoshihiko.

In: Oncology Letters, Vol. 2, No. 5, 01.09.2011, p. 791-796.

Research output: Contribution to journalArticle

Tsutsumi, N, Kohnoe, S, Sonoda, H, Guntani, A, Rikimaru, T, Taguchi, KI, Tomikawa, M, Kakeji, Y, Nakashima, H & Maehara, Y 2011, 'Protein-bound polysaccharide-K reduces colitic tumors and improves survival of inflammatory bowel disease in vivo', Oncology Letters, vol. 2, no. 5, pp. 791-796. https://doi.org/10.3892/ol.2011.336
Tsutsumi, Norifumi ; Kohnoe, Shunji ; Sonoda, Hideto ; Guntani, Atsushi ; Rikimaru, Tatsuya ; Taguchi, Ken Ichi ; Tomikawa, Morimasa ; Kakeji, Yoshihiro ; Nakashima, Hideaki ; Maehara, Yoshihiko. / Protein-bound polysaccharide-K reduces colitic tumors and improves survival of inflammatory bowel disease in vivo. In: Oncology Letters. 2011 ; Vol. 2, No. 5. pp. 791-796.
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