Protein kinase Cα as a therapeutic target in cancer

Jeong Hun Kang, Junichi Inokuchi, Takahito Kawano, Masaharu Murata

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Based on structural and activation characteristics, the protein kinase C(PKC) family can be classified into three isozymal subtypes: conventional or classic (cPKCs: α ΒI, ΒII and γ), novel or non-classic (nPKCs: δ, ε, η and θ) and atypical (aPKCs: ζ, ι and λ). Among cPKC isozymes, PKCa acts directly and/or indirectly in a variety of signaling mechanisms in cancer cells, including proliferation, survival, invasion, migration, apoptosis and drug resistance. Furthermore, overexpression of PKC α has been reported in bladder, breast, lung, ovarian, prostate and pancreatic cancer, as well as melanoma and glioma. Because of its key roles in cancer cells, PKC α is considered to be a promising therapeutic target. Several PKC α-targeted therapeutic molecules have been developed, and clinical trials to evaluate their efficacy and safety in cancer patients have been performed. This chapter primarily focuses on the expression pattern and function of PKC α in cancer cells, and newly emerging PKCα-targeted cancer therapies.

Original languageEnglish
Title of host publicationProtein Kinase C
Subtitle of host publicationEmerging Roles and Therapeutic Potential
PublisherNova Science Publishers, Inc.
Pages25-47
Number of pages23
ISBN (Electronic)9781536132113
ISBN (Print)9781536132106
Publication statusPublished - Jan 1 2018

All Science Journal Classification (ASJC) codes

  • Chemistry(all)

Fingerprint Dive into the research topics of 'Protein kinase Cα as a therapeutic target in cancer'. Together they form a unique fingerprint.

  • Cite this

    Kang, J. H., Inokuchi, J., Kawano, T., & Murata, M. (2018). Protein kinase Cα as a therapeutic target in cancer. In Protein Kinase C: Emerging Roles and Therapeutic Potential (pp. 25-47). Nova Science Publishers, Inc..