Protein Resistance Driven by Polymer Nanoarchitecture

Maya K. Endoh, Yuma Morimitsu, Daniel Salatto, Zhixing Huang, Mani Sen, Weiyi Li, Yizhi Meng, David G. Thanassi, Jan Michael Y. Carrillo, Bobby G. Sumpter, Daisuke Kawaguchi, Keiji Tanaka, Tadanori Koga

Research output: Contribution to journalArticle

Abstract

We report that the nanometer-scale architecture of polymer chains plays a crucial role in its protein resistant property over surface chemistry. Protein-repellent (noncharged), few nanometer thick polymer layers were designed with homopolymer chains physisorbed on solids. We evaluated the antifouling property of the hydrophilic or hydrophobic adsorbed homopolymer chains against bovine serum albumin in water. Molecular dynamics simulations along with sum frequency generation spectroscopy data revealed the self-organized nanoarchitecture of the adsorbed chains composed of inner nematic-like ordered segments and outer brush-like segments across homopolymer systems with different interactions among a polymer, substrate, and interfacial water. We propose that this structure acts as a dual barrier against protein adsorption.

Original languageEnglish
Pages (from-to)1153-1159
Number of pages7
JournalACS Macro Letters
Volume8
Issue number9
DOIs
Publication statusPublished - Sep 17 2019

Fingerprint

Homopolymerization
Polymers
Proteins
Water
Brushes
Bovine Serum Albumin
Surface chemistry
Molecular dynamics
Spectroscopy
Adsorption
Computer simulation
Substrates

All Science Journal Classification (ASJC) codes

  • Organic Chemistry
  • Polymers and Plastics
  • Inorganic Chemistry
  • Materials Chemistry

Cite this

Endoh, M. K., Morimitsu, Y., Salatto, D., Huang, Z., Sen, M., Li, W., ... Koga, T. (2019). Protein Resistance Driven by Polymer Nanoarchitecture. ACS Macro Letters, 8(9), 1153-1159. https://doi.org/10.1021/acsmacrolett.9b00518

Protein Resistance Driven by Polymer Nanoarchitecture. / Endoh, Maya K.; Morimitsu, Yuma; Salatto, Daniel; Huang, Zhixing; Sen, Mani; Li, Weiyi; Meng, Yizhi; Thanassi, David G.; Carrillo, Jan Michael Y.; Sumpter, Bobby G.; Kawaguchi, Daisuke; Tanaka, Keiji; Koga, Tadanori.

In: ACS Macro Letters, Vol. 8, No. 9, 17.09.2019, p. 1153-1159.

Research output: Contribution to journalArticle

Endoh, MK, Morimitsu, Y, Salatto, D, Huang, Z, Sen, M, Li, W, Meng, Y, Thanassi, DG, Carrillo, JMY, Sumpter, BG, Kawaguchi, D, Tanaka, K & Koga, T 2019, 'Protein Resistance Driven by Polymer Nanoarchitecture', ACS Macro Letters, vol. 8, no. 9, pp. 1153-1159. https://doi.org/10.1021/acsmacrolett.9b00518
Endoh MK, Morimitsu Y, Salatto D, Huang Z, Sen M, Li W et al. Protein Resistance Driven by Polymer Nanoarchitecture. ACS Macro Letters. 2019 Sep 17;8(9):1153-1159. https://doi.org/10.1021/acsmacrolett.9b00518
Endoh, Maya K. ; Morimitsu, Yuma ; Salatto, Daniel ; Huang, Zhixing ; Sen, Mani ; Li, Weiyi ; Meng, Yizhi ; Thanassi, David G. ; Carrillo, Jan Michael Y. ; Sumpter, Bobby G. ; Kawaguchi, Daisuke ; Tanaka, Keiji ; Koga, Tadanori. / Protein Resistance Driven by Polymer Nanoarchitecture. In: ACS Macro Letters. 2019 ; Vol. 8, No. 9. pp. 1153-1159.
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