Trimethylamine N-oxide (TMAO) protects proteins against denaturing stresses. In this study, a vinyl polymer with a TMAO side chain was synthesized and its effects on protein stabilization were evaluated. UV spectroscopy analysis showed that the polymer exhibited protein stabilization characteristics. Furthermore, an enzyme activity assay indicated that the polymer showed a remarkable preservation effect at 4°C compared to other commonly used additives. Therefore, TMAO-bearing polymer can potentially be used as a stabilizer for biochemical and pharmaceutical applications.
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