Protein stabilization effect of zwitterionic osmolyte-bearing polymer

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1 Citation (Scopus)

Abstract

Trimethylamine N-oxide (TMAO) protects proteins against denaturing stresses. In this study, a vinyl polymer with a TMAO side chain was synthesized and its effects on protein stabilization were evaluated. UV spectroscopy analysis showed that the polymer exhibited protein stabilization characteristics. Furthermore, an enzyme activity assay indicated that the polymer showed a remarkable preservation effect at 4°C compared to other commonly used additives. Therefore, TMAO-bearing polymer can potentially be used as a stabilizer for biochemical and pharmaceutical applications.

Original languageEnglish
Pages (from-to)1699-1702
Number of pages4
JournalChemistry Letters
Volume50
Issue number9
DOIs
Publication statusPublished - Sep 2021

All Science Journal Classification (ASJC) codes

  • Chemistry(all)

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