Proteolytic cascades and their involvement in invertebrate immunity

Lage Cerenius, Shun-Ichiro Kawabata, Bok Luel Lee, Masaru Nonaka, Kenneth Söderhäll

Research output: Contribution to journalReview article

192 Citations (Scopus)

Abstract

Bacteria and other potential pathogens are cleared rapidly from the body fluids of invertebrates by the immediate response of the innate immune system. Proteolytic cascades, following their initiation by pattern recognition proteins, control several such reactions, notably coagulation, melanisation, activation of the Toll receptor and complement-like reactions. However, there is considerable variation among invertebrates and these cascades, although widespread, are not present in all phyla. In recent years, significant progress has been made in identifying and characterizing these cascades in insects. Notably, recent work has identified several connections and shared principles among the different pathways, suggesting that cross-talk between them may be common.

Original languageEnglish
Pages (from-to)575-583
Number of pages9
JournalTrends in Biochemical Sciences
Volume35
Issue number10
DOIs
Publication statusPublished - Oct 1 2010

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Invertebrates
Immunity
Complement Receptors
Immune system
Toll-Like Receptors
Body fluids
Body Fluids
Pathogens
Coagulation
Pattern recognition
Insects
Immune System
Bacteria
Chemical activation
Proteins

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology

Cite this

Proteolytic cascades and their involvement in invertebrate immunity. / Cerenius, Lage; Kawabata, Shun-Ichiro; Lee, Bok Luel; Nonaka, Masaru; Söderhäll, Kenneth.

In: Trends in Biochemical Sciences, Vol. 35, No. 10, 01.10.2010, p. 575-583.

Research output: Contribution to journalReview article

Cerenius, Lage ; Kawabata, Shun-Ichiro ; Lee, Bok Luel ; Nonaka, Masaru ; Söderhäll, Kenneth. / Proteolytic cascades and their involvement in invertebrate immunity. In: Trends in Biochemical Sciences. 2010 ; Vol. 35, No. 10. pp. 575-583.
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