Abstract
Bacteria and other potential pathogens are cleared rapidly from the body fluids of invertebrates by the immediate response of the innate immune system. Proteolytic cascades, following their initiation by pattern recognition proteins, control several such reactions, notably coagulation, melanisation, activation of the Toll receptor and complement-like reactions. However, there is considerable variation among invertebrates and these cascades, although widespread, are not present in all phyla. In recent years, significant progress has been made in identifying and characterizing these cascades in insects. Notably, recent work has identified several connections and shared principles among the different pathways, suggesting that cross-talk between them may be common.
| Original language | English |
|---|---|
| Pages (from-to) | 575-583 |
| Number of pages | 9 |
| Journal | Trends in Biochemical Sciences |
| Volume | 35 |
| Issue number | 10 |
| DOIs | |
| Publication status | Published - Oct 1 2010 |
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All Science Journal Classification (ASJC) codes
- Biochemistry
- Molecular Biology
Cite this
Proteolytic cascades and their involvement in invertebrate immunity. / Cerenius, Lage; Kawabata, Shun-Ichiro; Lee, Bok Luel; Nonaka, Masaru; Söderhäll, Kenneth.
In: Trends in Biochemical Sciences, Vol. 35, No. 10, 01.10.2010, p. 575-583.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Proteolytic cascades and their involvement in invertebrate immunity
AU - Cerenius, Lage
AU - Kawabata, Shun-Ichiro
AU - Lee, Bok Luel
AU - Nonaka, Masaru
AU - Söderhäll, Kenneth
PY - 2010/10/1
Y1 - 2010/10/1
N2 - Bacteria and other potential pathogens are cleared rapidly from the body fluids of invertebrates by the immediate response of the innate immune system. Proteolytic cascades, following their initiation by pattern recognition proteins, control several such reactions, notably coagulation, melanisation, activation of the Toll receptor and complement-like reactions. However, there is considerable variation among invertebrates and these cascades, although widespread, are not present in all phyla. In recent years, significant progress has been made in identifying and characterizing these cascades in insects. Notably, recent work has identified several connections and shared principles among the different pathways, suggesting that cross-talk between them may be common.
AB - Bacteria and other potential pathogens are cleared rapidly from the body fluids of invertebrates by the immediate response of the innate immune system. Proteolytic cascades, following their initiation by pattern recognition proteins, control several such reactions, notably coagulation, melanisation, activation of the Toll receptor and complement-like reactions. However, there is considerable variation among invertebrates and these cascades, although widespread, are not present in all phyla. In recent years, significant progress has been made in identifying and characterizing these cascades in insects. Notably, recent work has identified several connections and shared principles among the different pathways, suggesting that cross-talk between them may be common.
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UR - http://www.scopus.com/inward/citedby.url?scp=77957221590&partnerID=8YFLogxK
U2 - 10.1016/j.tibs.2010.04.006
DO - 10.1016/j.tibs.2010.04.006
M3 - Review article
C2 - 20541942
AN - SCOPUS:77957221590
VL - 35
SP - 575
EP - 583
JO - Trends in Biochemical Sciences
JF - Trends in Biochemical Sciences
SN - 0376-5067
IS - 10
ER -