Prothrombin complex concentrate for rapid reversal of warfarin-induced anticoagulation and intracerebral hemorrhage in patients supported by a left ventricular assist device

Ayako Takahashi, Tomoko S. Kato, Noboru Oda, Kazuo Komamura, Hideaki Kanzaki, Masaki Asakura, Kazuhiko Hashimura, Kazuo Niwaya, Toshiaki Funatsu, Takeshi Nakatani, Junjiro Kobayashi, Soichiro Kitamura, Toshiaki Shishido, Shigeki Miyata, Jun C. Takahashi, Koji Iihara, Masafumi Kitakaze

Research output: Contribution to journalArticle

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Abstract

Background Intracerebral hemorrhage (ICH) is one of the most serious complications in patients supported by a left ventricular assist device (LVAD). We evaluate the efficacy of prothrombin complex concentrate (PCC) for rapid reversal of warfarin-induced anticoagulation in this population. Methods A total of 38 consecutive ICH events in patients supported by an LVAD between 1996 and 2007 were retrospectively reviewed. Fourteen ICH events were treated with fresh frozen plasma (FFP) (Group FFP) and 24 ICH events were treated with PCC (Group PCC). The efficacy and outcome of PCC administration versus FFP were evaluated. Results The proportion of patients surviving after an ICH event was significantly smaller in Group FFP than Group PCC (35.7 vs. 75.0, p < 0.05). None of the patients in Group FFP were able to undergo heart transplantation, whereas 21.4 patients in Group PCC successfully underwent heart transplantation. Conclusion Patients on LVAD are in need for intensified anticoagulation and are at high risk of ICH; therefore, adequate use of PCC in the event of ICH could be of importance for survival and allow subsequent heart transplantation.

Original languageEnglish
Pages (from-to)143-147
Number of pages5
JournalInternational Journal of Gerontology
Volume4
Issue number3
DOIs
Publication statusPublished - Sep 1 2010
Externally publishedYes

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Heart-Assist Devices
Cerebral Hemorrhage
Warfarin
Heart Transplantation
prothrombin complex concentrates
Survival
Population

All Science Journal Classification (ASJC) codes

  • Geriatrics and Gerontology

Cite this

Prothrombin complex concentrate for rapid reversal of warfarin-induced anticoagulation and intracerebral hemorrhage in patients supported by a left ventricular assist device. / Takahashi, Ayako; Kato, Tomoko S.; Oda, Noboru; Komamura, Kazuo; Kanzaki, Hideaki; Asakura, Masaki; Hashimura, Kazuhiko; Niwaya, Kazuo; Funatsu, Toshiaki; Nakatani, Takeshi; Kobayashi, Junjiro; Kitamura, Soichiro; Shishido, Toshiaki; Miyata, Shigeki; Takahashi, Jun C.; Iihara, Koji; Kitakaze, Masafumi.

In: International Journal of Gerontology, Vol. 4, No. 3, 01.09.2010, p. 143-147.

Research output: Contribution to journalArticle

Takahashi, A, Kato, TS, Oda, N, Komamura, K, Kanzaki, H, Asakura, M, Hashimura, K, Niwaya, K, Funatsu, T, Nakatani, T, Kobayashi, J, Kitamura, S, Shishido, T, Miyata, S, Takahashi, JC, Iihara, K & Kitakaze, M 2010, 'Prothrombin complex concentrate for rapid reversal of warfarin-induced anticoagulation and intracerebral hemorrhage in patients supported by a left ventricular assist device', International Journal of Gerontology, vol. 4, no. 3, pp. 143-147. https://doi.org/10.1016/S1873-9598(10)70038-7
Takahashi, Ayako ; Kato, Tomoko S. ; Oda, Noboru ; Komamura, Kazuo ; Kanzaki, Hideaki ; Asakura, Masaki ; Hashimura, Kazuhiko ; Niwaya, Kazuo ; Funatsu, Toshiaki ; Nakatani, Takeshi ; Kobayashi, Junjiro ; Kitamura, Soichiro ; Shishido, Toshiaki ; Miyata, Shigeki ; Takahashi, Jun C. ; Iihara, Koji ; Kitakaze, Masafumi. / Prothrombin complex concentrate for rapid reversal of warfarin-induced anticoagulation and intracerebral hemorrhage in patients supported by a left ventricular assist device. In: International Journal of Gerontology. 2010 ; Vol. 4, No. 3. pp. 143-147.
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abstract = "Background Intracerebral hemorrhage (ICH) is one of the most serious complications in patients supported by a left ventricular assist device (LVAD). We evaluate the efficacy of prothrombin complex concentrate (PCC) for rapid reversal of warfarin-induced anticoagulation in this population. Methods A total of 38 consecutive ICH events in patients supported by an LVAD between 1996 and 2007 were retrospectively reviewed. Fourteen ICH events were treated with fresh frozen plasma (FFP) (Group FFP) and 24 ICH events were treated with PCC (Group PCC). The efficacy and outcome of PCC administration versus FFP were evaluated. Results The proportion of patients surviving after an ICH event was significantly smaller in Group FFP than Group PCC (35.7 vs. 75.0, p < 0.05). None of the patients in Group FFP were able to undergo heart transplantation, whereas 21.4 patients in Group PCC successfully underwent heart transplantation. Conclusion Patients on LVAD are in need for intensified anticoagulation and are at high risk of ICH; therefore, adequate use of PCC in the event of ICH could be of importance for survival and allow subsequent heart transplantation.",
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AU - Kato, Tomoko S.

AU - Oda, Noboru

AU - Komamura, Kazuo

AU - Kanzaki, Hideaki

AU - Asakura, Masaki

AU - Hashimura, Kazuhiko

AU - Niwaya, Kazuo

AU - Funatsu, Toshiaki

AU - Nakatani, Takeshi

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AU - Kitamura, Soichiro

AU - Shishido, Toshiaki

AU - Miyata, Shigeki

AU - Takahashi, Jun C.

AU - Iihara, Koji

AU - Kitakaze, Masafumi

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