Protrudin induces neurite formation by directional membrane trafficking

Michiko Shirane, Keiichi I. Nakayama

Research output: Contribution to journalArticle

129 Citations (Scopus)

Abstract

Guanosine triphosphatases of the Rab family are key regulators of membrane trafficking, with Rab11 playing a specific role in membrane recycling. We identified a mammalian protein, protrudin, that promoted neurite formation through interaction with the guanosine diphosphate (GDP)-bound form of Rab11. Phosphprylation of protrudin by extracellular signal-regulated kinase (ERK) in response to nerve growth factor promoted protrudin association with Rab11-GDP. Down-regulation of protrudin by RNA interference induced membrane extension in all directions and inhibited neurite formation. Thus, protrudin regulates Rab11-dependent membrane recycling to promote the directional membrane trafficking required for neurite formation.

Original languageEnglish
Pages (from-to)818-821
Number of pages4
JournalScience
Volume314
Issue number5800
DOIs
Publication statusPublished - Nov 3 2006

All Science Journal Classification (ASJC) codes

  • General

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