Pseudoprogression following concurrent temozolomide and radiotherapy in a patient with glioblastoma

findings on functional imaging techniques.

yuko shirakawa, Takashi Yoshiura, Hiwatashi Akio, Koji Yamashita, Hironori Kamano, Yoshiyuki Shioyama, Kouichiro Abe, Toshiyuki Amano, Akira Nakamizo, Koji Yoshimoto, Hiroyuki Honda, Rina Torisu, Satoshi Suzuki, Hiroshi Honda

Research output: Contribution to journalArticle

Abstract

Concurrent temozolomide (TMZ) and radiotherapy became the new standard of care for patients diagnosed with glioblastoma multiforme (GBM). Recently, there has been an increasing awareness of progressive and enhancing lesions on MR images immediately after treatment. These lesions may be a treatment effect, so-called pseudoprogression. We experienced one case pathologically and clinically diagnosed as pseudoprogression. The lesion showed a high apparent diffusion coefficient on diffusion-weighted imaging, low blood volume on perfusion imaging, and low uptake of 18F-fluorodeoxyglucose on positron emission tomography. The lesion was pathologically diagnosed as pseudoprogression after additional surgical resection.

Original languageEnglish
Pages (from-to)257-264
Number of pages8
JournalFukuoka igaku zasshi = Hukuoka acta medica
Volume101
Issue number12
Publication statusPublished - Dec 1 2010

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temozolomide
Glioblastoma
Radiotherapy
Perfusion Imaging
Fluorodeoxyglucose F18
Standard of Care
Blood Volume
Positron-Emission Tomography
Therapeutics

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Pseudoprogression following concurrent temozolomide and radiotherapy in a patient with glioblastoma : findings on functional imaging techniques. / shirakawa, yuko; Yoshiura, Takashi; Akio, Hiwatashi; Yamashita, Koji; Kamano, Hironori; Shioyama, Yoshiyuki; Abe, Kouichiro; Amano, Toshiyuki; Nakamizo, Akira; Yoshimoto, Koji; Honda, Hiroyuki; Torisu, Rina; Suzuki, Satoshi; Honda, Hiroshi.

In: Fukuoka igaku zasshi = Hukuoka acta medica, Vol. 101, No. 12, 01.12.2010, p. 257-264.

Research output: Contribution to journalArticle

shirakawa, yuko ; Yoshiura, Takashi ; Akio, Hiwatashi ; Yamashita, Koji ; Kamano, Hironori ; Shioyama, Yoshiyuki ; Abe, Kouichiro ; Amano, Toshiyuki ; Nakamizo, Akira ; Yoshimoto, Koji ; Honda, Hiroyuki ; Torisu, Rina ; Suzuki, Satoshi ; Honda, Hiroshi. / Pseudoprogression following concurrent temozolomide and radiotherapy in a patient with glioblastoma : findings on functional imaging techniques. In: Fukuoka igaku zasshi = Hukuoka acta medica. 2010 ; Vol. 101, No. 12. pp. 257-264.
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