Pseudorabies virus early protein O transactivates the viral gene promoters

S. Watanabe, E. Ono, Y. Shimizu, H. Kida

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Pseudorabies virus (PRV) early protein O (EPO) contains the RING finger domain with homology to the immediate-early (IE) protein ICPO of herpes simplex virus type 1 (HSV-I). EPO was detected by indirect immunefluorescence in the nuclei of the cells transfected with EPO expression plasmid as is the case in cells infected with PRV. In transient expression assays, EPO transactivated the PRV IE, thymidine kinase (TK) and glycopretein X (gX) promoters, indicating that EPO, like ICPO of HSV-I, is a transactivating protein.

Original languageEnglish
Pages (from-to)2881-2885
Number of pages5
JournalJournal of General Virology
Issue number11
Publication statusPublished - Jan 1 1995
Externally publishedYes


All Science Journal Classification (ASJC) codes

  • Virology

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