Psychological mediation of a type of oxidative DNA damage, 8-hydroxydeoxyguanosine, in peripheral blood leukocytes of non-smoking and non-drinking workers

Masahiro Irie, Shinya Asami, Shoji Nagata, Masakazu Miyata, Hiroshi Kasai

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Background: The present study investigates whether the formation of 8-hydroxydeoxyguanosine (8-OH-dG), a known oxidative DNA damage relevant to carcinogenicity, can be associated with psychological factors, in order to clarify the possible stress-cancer linkage from a genetic viewpoint. Methods: We performed a cross-sectional study in which we examined the relationships of the levels of 8-OH-dG in peripheral blood leukocytes to various psychological factors, including the Profile of Mood States (POMS) and the Center for Epidemiologic Studies Depression Scale (CES-D) in 38 non-smoking and non-drinking workers (19 males and 19 females). Results: The levels of 8-OH-dG in male subjects were negatively correlated with the Tension-Anxiety scores of the POMS. In contrast, the levels of 8-OH-dG in female subjects were positively correlated with the Depression-Rejection scores of the POMS and the CES-D scores, and negatively associated with the Vigor scores of the POMS, respectively. Male subjects who had self-blame coping strategy displayed significantly high levels of 8-OH-dG. Moreover, the worse the subjective closeness to parents in childhood, the higher the levels of 8-OH-dG became in male subjects. The levels of 8-OH-dG increased reliably in subjects who had experienced the loss of a close family member within 3 years, when compared with non-bereaved subjects. Conclusions: Psychological distress may be associated with cancer risk, although sex difference influences them. Inadequate coping styles, possibly resulting from a poor interpersonal relationship with parents since childhood, and experience of a relatively recent loss of a close family member also appear to influence the pathogenesis of cancer.

Original languageEnglish
Pages (from-to)90-96
Number of pages7
JournalPsychotherapy and Psychosomatics
Volume71
Issue number2
DOIs
Publication statusPublished - Mar 2 2002
Externally publishedYes

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DNA Damage
Leukocytes
Psychology
Depression
Epidemiologic Studies
Parents
Neoplasms
Genetic Linkage
8-oxo-7-hydrodeoxyguanosine
hydroxide ion
Sex Characteristics
Anxiety
Cross-Sectional Studies

All Science Journal Classification (ASJC) codes

  • Clinical Psychology
  • Applied Psychology
  • Psychiatry and Mental health

Cite this

Psychological mediation of a type of oxidative DNA damage, 8-hydroxydeoxyguanosine, in peripheral blood leukocytes of non-smoking and non-drinking workers. / Irie, Masahiro; Asami, Shinya; Nagata, Shoji; Miyata, Masakazu; Kasai, Hiroshi.

In: Psychotherapy and Psychosomatics, Vol. 71, No. 2, 02.03.2002, p. 90-96.

Research output: Contribution to journalArticle

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