TY - JOUR
T1 - Psychological stress in a Japanese population with systemic lupus erythematosus
T2 - Finding from KYSS study
AU - Takahashi, Hiroki
AU - Washio, Masakazu
AU - Kiyohara, Chikako
AU - Tada, Yoshifumi
AU - Asami, Toyoko
AU - Ide, Saburo
AU - Atsumi, Tatsuya
AU - Kobashi, Gen
AU - Yamamoto, Motohisa
AU - Horiuchi, Takahiko
N1 - Funding Information:
This work was supported in part by Health and Labour Sciences Research Grants, Research on Intractable Diseases, and the Research Committee on Epidemiology of Intractable Diseases from the Ministry of Health, Labour, and Welfare, Japan (Chief: Yutaka Inaba, 2002-04 and Masaki Nagai, 2004-10).
PY - 2014/5
Y1 - 2014/5
N2 - Objectives. Daily psychological stress has been proposed as a risk factor for systemic lupus erythematosus (SLE) in Western countries. However, there is little information about the relationship between daily psychological stress and the risk of SLE in a Japanese population. We examined the association between SLE and daily psychological stress. Methods. A case-control study was conducted to examine the relationship between daily psychological stress and SLE in Japanese females. The participants were 160 female SLE patients and 660 female volunteers. Unconditional logistic regression was used to compute OR and 95% confidence interval (CI), with adjustment for several covariates. Results. Smoking (OR = 2.59; 95% CI, 1.74-3.86), walking (OR = 1.75; 95% CI, 1.81-2.56) and daily psychological stress (OR = 1.88; 95% CI, 1.14-3.10) were increased in patients with SLE after adjusting for age, region and all factors. Smokers with daily psychological stress (OR = 4.70; 95% CI = 2.53-8.77) were more prevalent than nonsmokers without daily psychological stress in SLE. The multiplicative interaction measures between smoking status and daily psychological stress did not reach statistical significance. Conclusions. The present study suggests the possibility that daily psychological stress as well as smoking might be associated with an increased risk of SLE.
AB - Objectives. Daily psychological stress has been proposed as a risk factor for systemic lupus erythematosus (SLE) in Western countries. However, there is little information about the relationship between daily psychological stress and the risk of SLE in a Japanese population. We examined the association between SLE and daily psychological stress. Methods. A case-control study was conducted to examine the relationship between daily psychological stress and SLE in Japanese females. The participants were 160 female SLE patients and 660 female volunteers. Unconditional logistic regression was used to compute OR and 95% confidence interval (CI), with adjustment for several covariates. Results. Smoking (OR = 2.59; 95% CI, 1.74-3.86), walking (OR = 1.75; 95% CI, 1.81-2.56) and daily psychological stress (OR = 1.88; 95% CI, 1.14-3.10) were increased in patients with SLE after adjusting for age, region and all factors. Smokers with daily psychological stress (OR = 4.70; 95% CI = 2.53-8.77) were more prevalent than nonsmokers without daily psychological stress in SLE. The multiplicative interaction measures between smoking status and daily psychological stress did not reach statistical significance. Conclusions. The present study suggests the possibility that daily psychological stress as well as smoking might be associated with an increased risk of SLE.
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U2 - 10.3109/14397595.2013.843745
DO - 10.3109/14397595.2013.843745
M3 - Article
C2 - 24252033
AN - SCOPUS:84900435843
SN - 1439-7595
VL - 24
SP - 448
EP - 452
JO - Modern Rheumatology
JF - Modern Rheumatology
IS - 3
ER -