Psychosocial factors as a potential trigger of oxidative DNA damage in human leukocytes

Masahiro Irie, S. Asami, S. Nagata, M. Ikeda, M. Miyata, H. Kasai

Research output: Contribution to journalArticle

71 Citations (Scopus)

Abstract

Although numerous studies have been carried out on the stress-cancer linkage, the results are still inconclusive. One of the useful, but rarely applied, methods to assess this linkage is to examine the relationship between psychosocial stress and cancer-predisposing genetic alterations simultaneously. We investigated whether various psychosocial factors can be associated with the levels of 8-hydroxydeoxyguanosine (8-OH-dG), a biomarker of cancer-related oxidative DNA damage, in peripheral blood leukocytes in 362 healthy workers (276 males and 86 females). After adjustments for age, body mass index, cigarette smoking, and alcohol use, female subjects showed positive relationships between the amount of 8-OH-dG and the Tension-Anxiety, Depression-Rejection, Anger-Hostility, Fatigue, and Confusion scores of the Profile of Mood States, respectively. The levels of 8-OH-dG also increased reliably in the female subjects who had poor stress-coping behaviors, particularly wishful thinking strategy, in the NIOSH general job stress instrument. There were positive relationships of the 8-OH-dG levels to average working hours, a self-blame coping strategy, and recent loss of a close family member in male subjects. These findings in a nonclinical sample of healthy adults not only provide evidence of a stress-cancer linkage, but also suggest possible sex differences in the mechanisms of stress-related cancer initiation.

Original languageEnglish
Pages (from-to)367-375
Number of pages9
JournalJapanese Journal of Cancer Research
Volume92
Issue number3
Publication statusPublished - 2001
Externally publishedYes

Fingerprint

DNA Damage
Leukocytes
Psychology
Neoplasms
National Institute for Occupational Safety and Health (U.S.)
Confusion
Hostility
Psychological Adaptation
Anger
Tumor Biomarkers
Sex Characteristics
Fatigue
Body Mass Index
Anxiety
Smoking
Alcohols
8-oxo-7-hydrodeoxyguanosine
Depression
hydroxide ion

All Science Journal Classification (ASJC) codes

  • Cancer Research
  • Oncology

Cite this

Irie, M., Asami, S., Nagata, S., Ikeda, M., Miyata, M., & Kasai, H. (2001). Psychosocial factors as a potential trigger of oxidative DNA damage in human leukocytes. Japanese Journal of Cancer Research, 92(3), 367-375.

Psychosocial factors as a potential trigger of oxidative DNA damage in human leukocytes. / Irie, Masahiro; Asami, S.; Nagata, S.; Ikeda, M.; Miyata, M.; Kasai, H.

In: Japanese Journal of Cancer Research, Vol. 92, No. 3, 2001, p. 367-375.

Research output: Contribution to journalArticle

Irie, M, Asami, S, Nagata, S, Ikeda, M, Miyata, M & Kasai, H 2001, 'Psychosocial factors as a potential trigger of oxidative DNA damage in human leukocytes', Japanese Journal of Cancer Research, vol. 92, no. 3, pp. 367-375.
Irie, Masahiro ; Asami, S. ; Nagata, S. ; Ikeda, M. ; Miyata, M. ; Kasai, H. / Psychosocial factors as a potential trigger of oxidative DNA damage in human leukocytes. In: Japanese Journal of Cancer Research. 2001 ; Vol. 92, No. 3. pp. 367-375.
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