Pulmonary fat embolism induced by exposure to high ambient temperature in rats with a fatty liver

Hiromasa Inoue, Akiko Tsuji, Keiko Kudo, Noriaki Ikeda

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

The aim of this study was to investigate whether a fatty liver contributes to pulmonary embolism under a high ambient temperature. As an experimental model, we exposed fatty liver rats to a high temperature (45°C) and then looked for fat emboli in the alveolar capillaries using the fat-staining method. Fat emboli were detected in the alveolar capillaries of the fatty liver rats, but not in those of the normal liver rats. Moreover, the degree of pulmonary fat embolism tended to become more severe in proportion to the severity of the fatty liver. In addition, fat emboli did not appear at a core body temperature of 40°C, but were detected at a core body temperature of 44°C. From these results, we conclude that a fatty liver may contribute to the formation of pulmonary fat embolism and that high temperatures act as a trigger for the onset of pulmonary embolism. Moreover, it is possible that fatty liver affects the development of heat stroke induced by exposure to a high ambient temperature and that pulmonary fat embolism is a significant finding which helps to enable a diagnosis of heat stroke in autopsy cases.

Original languageEnglish
Pages (from-to)275-279
Number of pages5
JournalInternational Journal of Legal Medicine
Volume119
Issue number5
DOIs
Publication statusPublished - Sep 1 2005

Fingerprint

Fat Embolism
Fatty Liver
Pulmonary Embolism
Temperature
Embolism
Fats
Heat Stroke
Body Temperature
Autopsy
Theoretical Models
Staining and Labeling
Liver

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine

Cite this

Pulmonary fat embolism induced by exposure to high ambient temperature in rats with a fatty liver. / Inoue, Hiromasa; Tsuji, Akiko; Kudo, Keiko; Ikeda, Noriaki.

In: International Journal of Legal Medicine, Vol. 119, No. 5, 01.09.2005, p. 275-279.

Research output: Contribution to journalArticle

@article{a9937043810748cd908705721acb8b68,
title = "Pulmonary fat embolism induced by exposure to high ambient temperature in rats with a fatty liver",
abstract = "The aim of this study was to investigate whether a fatty liver contributes to pulmonary embolism under a high ambient temperature. As an experimental model, we exposed fatty liver rats to a high temperature (45°C) and then looked for fat emboli in the alveolar capillaries using the fat-staining method. Fat emboli were detected in the alveolar capillaries of the fatty liver rats, but not in those of the normal liver rats. Moreover, the degree of pulmonary fat embolism tended to become more severe in proportion to the severity of the fatty liver. In addition, fat emboli did not appear at a core body temperature of 40°C, but were detected at a core body temperature of 44°C. From these results, we conclude that a fatty liver may contribute to the formation of pulmonary fat embolism and that high temperatures act as a trigger for the onset of pulmonary embolism. Moreover, it is possible that fatty liver affects the development of heat stroke induced by exposure to a high ambient temperature and that pulmonary fat embolism is a significant finding which helps to enable a diagnosis of heat stroke in autopsy cases.",
author = "Hiromasa Inoue and Akiko Tsuji and Keiko Kudo and Noriaki Ikeda",
year = "2005",
month = "9",
day = "1",
doi = "10.1007/s00414-004-0514-8",
language = "English",
volume = "119",
pages = "275--279",
journal = "Zeitschrift fur Rechtsmedizin. Journal of legal medicine",
issn = "0937-9827",
publisher = "Springer Verlag",
number = "5",

}

TY - JOUR

T1 - Pulmonary fat embolism induced by exposure to high ambient temperature in rats with a fatty liver

AU - Inoue, Hiromasa

AU - Tsuji, Akiko

AU - Kudo, Keiko

AU - Ikeda, Noriaki

PY - 2005/9/1

Y1 - 2005/9/1

N2 - The aim of this study was to investigate whether a fatty liver contributes to pulmonary embolism under a high ambient temperature. As an experimental model, we exposed fatty liver rats to a high temperature (45°C) and then looked for fat emboli in the alveolar capillaries using the fat-staining method. Fat emboli were detected in the alveolar capillaries of the fatty liver rats, but not in those of the normal liver rats. Moreover, the degree of pulmonary fat embolism tended to become more severe in proportion to the severity of the fatty liver. In addition, fat emboli did not appear at a core body temperature of 40°C, but were detected at a core body temperature of 44°C. From these results, we conclude that a fatty liver may contribute to the formation of pulmonary fat embolism and that high temperatures act as a trigger for the onset of pulmonary embolism. Moreover, it is possible that fatty liver affects the development of heat stroke induced by exposure to a high ambient temperature and that pulmonary fat embolism is a significant finding which helps to enable a diagnosis of heat stroke in autopsy cases.

AB - The aim of this study was to investigate whether a fatty liver contributes to pulmonary embolism under a high ambient temperature. As an experimental model, we exposed fatty liver rats to a high temperature (45°C) and then looked for fat emboli in the alveolar capillaries using the fat-staining method. Fat emboli were detected in the alveolar capillaries of the fatty liver rats, but not in those of the normal liver rats. Moreover, the degree of pulmonary fat embolism tended to become more severe in proportion to the severity of the fatty liver. In addition, fat emboli did not appear at a core body temperature of 40°C, but were detected at a core body temperature of 44°C. From these results, we conclude that a fatty liver may contribute to the formation of pulmonary fat embolism and that high temperatures act as a trigger for the onset of pulmonary embolism. Moreover, it is possible that fatty liver affects the development of heat stroke induced by exposure to a high ambient temperature and that pulmonary fat embolism is a significant finding which helps to enable a diagnosis of heat stroke in autopsy cases.

UR - http://www.scopus.com/inward/record.url?scp=24344456084&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=24344456084&partnerID=8YFLogxK

U2 - 10.1007/s00414-004-0514-8

DO - 10.1007/s00414-004-0514-8

M3 - Article

VL - 119

SP - 275

EP - 279

JO - Zeitschrift fur Rechtsmedizin. Journal of legal medicine

JF - Zeitschrift fur Rechtsmedizin. Journal of legal medicine

SN - 0937-9827

IS - 5

ER -