Pulmonary nocardiosis developed in a hematopoietic stem cell transplant recipient with bronchiolitis obliterans

Ruriko Nishida; Yasuo Mori; Hiromi Iwasaki; Takahito Tokuyama; Kenjiro Kamezaki; Yoji Nagasaki; Hideyo Oka; Kohta Miyawaki; Noriyuki Saito; Katsuto Takenaka; Naoki Harada; Toshihiro Miyamoto; Takanori Teshima; Koichi Akashi

doi:10.2169/internalmedicine.49.3658

Pulmonary nocardiosis developed in a hematopoietic stem cell transplant recipient with bronchiolitis obliterans

Ruriko Nishida, Yasuo Mori, Hiromi Iwasaki, Takahito Tokuyama, Kenjiro Kamezaki, Yoji Nagasaki, Hideyo Oka, Kohta Miyawaki, Noriyuki Saito, Katsuto Takenaka, Naoki Harada, Toshihiro Miyamoto, Takanori Teshima, Koichi Akashi

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4 Citations (Scopus)

Abstract

The chronic graft-versus-host disease often requires unceasing immunosuppressive therapy (IST), which increases a risk of infectious complications in hematopoietic stem cell transplantation (HSCT) recipients. We report an adult T cell leukemia/lymphoma case who developed pulmonary nocardiosis, a rare pulmonary complication, after allogeneic HSCT despite administration of the prophylactic trimethoprimsulfamethoxazole (TMP/STX). The inhaled corticosteroid in addition to systemic IST had been started for bronchiolitis obliterance 4 months prior to nocardiosis development. The patient was successfully treated with an increased dose of TMP/STX combined with meropenem. Transplantation physicians should keep this rare pulmonary complication in mind during sustained IST.

Original language	English
Pages (from-to)	1441-1444
Number of pages	4
Journal	Internal Medicine
Volume	49
Issue number	14
DOIs	https://doi.org/10.2169/internalmedicine.49.3658
Publication status	Published - 2010

All Science Journal Classification (ASJC) codes

Internal Medicine

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Nishida, R., Mori, Y., Iwasaki, H., Tokuyama, T., Kamezaki, K., Nagasaki, Y., Oka, H., Miyawaki, K., Saito, N., Takenaka, K., Harada, N., Miyamoto, T., Teshima, T., & Akashi, K. (2010). Pulmonary nocardiosis developed in a hematopoietic stem cell transplant recipient with bronchiolitis obliterans. Internal Medicine, 49(14), 1441-1444. https://doi.org/10.2169/internalmedicine.49.3658

Nishida, R, Mori, Y, Iwasaki, H, Tokuyama, T, Kamezaki, K, Nagasaki, Y, Oka, H, Miyawaki, K, Saito, N, Takenaka, K, Harada, N, Miyamoto, T, Teshima, T & Akashi, K 2010, 'Pulmonary nocardiosis developed in a hematopoietic stem cell transplant recipient with bronchiolitis obliterans', Internal Medicine, vol. 49, no. 14, pp. 1441-1444. https://doi.org/10.2169/internalmedicine.49.3658

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title = "Pulmonary nocardiosis developed in a hematopoietic stem cell transplant recipient with bronchiolitis obliterans",

abstract = "The chronic graft-versus-host disease often requires unceasing immunosuppressive therapy (IST), which increases a risk of infectious complications in hematopoietic stem cell transplantation (HSCT) recipients. We report an adult T cell leukemia/lymphoma case who developed pulmonary nocardiosis, a rare pulmonary complication, after allogeneic HSCT despite administration of the prophylactic trimethoprimsulfamethoxazole (TMP/STX). The inhaled corticosteroid in addition to systemic IST had been started for bronchiolitis obliterance 4 months prior to nocardiosis development. The patient was successfully treated with an increased dose of TMP/STX combined with meropenem. Transplantation physicians should keep this rare pulmonary complication in mind during sustained IST.",

author = "Ruriko Nishida and Yasuo Mori and Hiromi Iwasaki and Takahito Tokuyama and Kenjiro Kamezaki and Yoji Nagasaki and Hideyo Oka and Kohta Miyawaki and Noriyuki Saito and Katsuto Takenaka and Naoki Harada and Toshihiro Miyamoto and Takanori Teshima and Koichi Akashi",

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T1 - Pulmonary nocardiosis developed in a hematopoietic stem cell transplant recipient with bronchiolitis obliterans

AU - Nishida, Ruriko

AU - Mori, Yasuo

AU - Iwasaki, Hiromi

AU - Tokuyama, Takahito

AU - Kamezaki, Kenjiro

AU - Nagasaki, Yoji

AU - Oka, Hideyo

AU - Miyawaki, Kohta

AU - Saito, Noriyuki

AU - Takenaka, Katsuto

AU - Harada, Naoki

AU - Miyamoto, Toshihiro

AU - Teshima, Takanori

AU - Akashi, Koichi

PY - 2010

Y1 - 2010

N2 - The chronic graft-versus-host disease often requires unceasing immunosuppressive therapy (IST), which increases a risk of infectious complications in hematopoietic stem cell transplantation (HSCT) recipients. We report an adult T cell leukemia/lymphoma case who developed pulmonary nocardiosis, a rare pulmonary complication, after allogeneic HSCT despite administration of the prophylactic trimethoprimsulfamethoxazole (TMP/STX). The inhaled corticosteroid in addition to systemic IST had been started for bronchiolitis obliterance 4 months prior to nocardiosis development. The patient was successfully treated with an increased dose of TMP/STX combined with meropenem. Transplantation physicians should keep this rare pulmonary complication in mind during sustained IST.

AB - The chronic graft-versus-host disease often requires unceasing immunosuppressive therapy (IST), which increases a risk of infectious complications in hematopoietic stem cell transplantation (HSCT) recipients. We report an adult T cell leukemia/lymphoma case who developed pulmonary nocardiosis, a rare pulmonary complication, after allogeneic HSCT despite administration of the prophylactic trimethoprimsulfamethoxazole (TMP/STX). The inhaled corticosteroid in addition to systemic IST had been started for bronchiolitis obliterance 4 months prior to nocardiosis development. The patient was successfully treated with an increased dose of TMP/STX combined with meropenem. Transplantation physicians should keep this rare pulmonary complication in mind during sustained IST.

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JO - Internal Medicine

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Pulmonary nocardiosis developed in a hematopoietic stem cell transplant recipient with bronchiolitis obliterans

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